Mahmoud Elguindy

Clinical Utility of Structural Blood-Based Biomarkers in Pediatric Traumatic Brain Injury: A Focused Review of GFAP, UCH-L1, and S100B

Allen Ye Fu, Mahmoud Elguindy, Angela Tang-Tan, David J. Caldwell et autres

Objective Blood-based biomarkers are becoming increasingly relevant for the diagnosis of acute traumatic brain injury (TBI) in adults, but they remain underutilized in children. There exists the need for high-quality evidence to support their use in defined clinical contexts. Methods This review …

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Bilateral bow hunter’s syndrome at the craniocervical junction: illustrative case

John M. Bernabei, Arati Patel, Hunter Yamada, Mahmoud Elguindy et autres

BACKGROUND: Rotational vertebrobasilar ischemia, also known as bow hunter's syndrome (BHS), is an underrecognized cause of posterior circulation stroke. Fewer than 200 cases have previously been documented, with most involving unilateral dynamic compression of the vertebral artery by adjacent bony structures that …

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Lateral Supracerebellar Infratentorial Approach for Resection of a Tegmental Midbrain Cavernous Malformation: 2-Dimensional Operative Video

John M. Bernabei, Mahmoud Elguindy, E Winkler

Brainstem cavernous malformations present a surgical challenge due to their deep location and proximity to critical structures. However, for lesions with recurrent hemorrhage, the risks of surgery may be lower than observation. Brainstem safe entry zones are well-established corridors through which intrinsic …

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Inflammatory blood-based biomarkers to aid in the assessment and prognostication of traumatic brain injury: a TRACK-TBI study

John K. Yue, Allen Y. Fu, Sonia Jain, Ava M. Puccio et autres

Abstract Background Inflammatory proteins detectable in blood reflect pathoanatomic injury patterns after traumatic brain injury (TBI). Identifying biomarkers of secondary neurologic and systemic injury may improve detection of patients at risk for clinical decline and chronic disability. This study examined the utility …

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Additional file 1 of Inflammatory blood-based biomarkers to aid in the assessment and prognostication of traumatic brain injury: a TRACK-TBI study

John K. Yue, Allen Y. Fu, Sonia Jain, Ava M. Puccio et autres

Supplementary Material 1.

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Additional file 1 of Inflammatory blood-based biomarkers to aid in the assessment and prognostication of traumatic brain injury: a TRACK-TBI study

John K. Yue, Allen Y. Fu, Sonia Jain, Ava M. Puccio et autres

Supplementary Material 1.

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Inflammatory blood-based biomarkers to aid in the assessment and prognostication of traumatic brain injury: a TRACK-TBI study

John K. Yue, Allen Y. Fu, Sonia Jain, Ava M. Puccio et autres

Abstract Background Inflammatory proteins detectable in blood reflect pathoanatomic injury patterns after traumatic brain injury (TBI). Identifying biomarkers of secondary neurologic and systemic injury may improve detection of patients at risk for clinical decline and chronic disability. This study examined the utility …

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Inflammatory blood-based biomarkers to aid in the assessment and prognostication of traumatic brain injury: a TRACK-TBI study

John K. Yue, Allen Y. Fu, Sonia Jain, Ava M. Puccio et autres

Abstract Background Inflammatory proteins detectable in blood reflect pathoanatomic injury patterns after traumatic brain injury (TBI). Identifying biomarkers of secondary neurologic and systemic injury may improve detection of patients at risk for clinical decline and chronic disability. This study examined the utility …

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Is there discordance between achieving the minimal clinically important difference in Neck Disability Index score and patient satisfaction after surgery for cervical spondylotic myelopathy? A Spine CORe™ 5-year analysis of QOD data

Nima Alan, Jay Kumar, Abraham Dada, Mahmoud Elguindy et autres

OBJECTIVE: Minimal clinically important difference (MCID) thresholds are widely used to evaluate outcomes after surgery for cervical spondylotic myelopathy (CSM), but they may not fully reflect patient satisfaction. The authors hypothesized that discordance exists between MCID achievement in Neck Disability Index (NDI) …

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Neuroworsening from a normal Glasgow Coma Scale Motor Score in the emergency department is an early predictor of neurosurgical intervention, hospital outcomes, and longitudinal disability in traumatic brain injury: A TRACK-TBI Study

John Yue, Allen Ye Fu, Mahmoud Elguindy, Thomas A. van Essen et autres

OBJECTIVE: Neuroworsening portends poor outcomes after traumatic brain injury (TBI) and is protocolized in intensive care unit (ICU) settings. The utility of neuroworsening assessments in non-ICU settings for intervention and prognostication requires further understanding. This study assessed relationships among neuroworsening in the …

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Gastrointestinal disorders in traumatic brain injury: pathophysiology, risk factors, and interventions

Allen Ye Fu, Mahmoud Elguindy, Geoffrey T. MANLEY, John Yue

INTRODUCTION: Traumatic brain injury (TBI) impacts over 69 million people annually worldwide and causes significant disability. Gastrointestinal (GI) dysfunction is becoming increasingly recognized as post-TBI sequelae, however best practices for their detection and management remain lacking. The current review aimed to improve …

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Genomics and proteomics in neurooncology

Mahmoud Elguindy, Manish K. Aghi