Mingliang Zhou

Biomimetic Mitochondrial Vesicles Delivered by Lubricative Hydrogel Microspheres Enable Cartilage Repair in Osteoarthritis

Yuran Li, Yulan Liu, Li Meng, Yingjie Hua et autres

ABSTRACT Mitochondrial dysfunction in chondrocytes and the loss of joint lubrication are increasingly recognized as key pathological drivers of functional deterioration in osteoarthritis (OA). However, the rational design of multifunctional biomaterials capable of concurrently regulating bioenergetic metabolism and the joint mechanical microenvironment …

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The PLAGL1-KLF4-IRX5 axis promotes the osteogenesis of periosteal progenitors during mandible regeneration

Enhui Yao, 刘伊丽, Jingyi Xu, Zeqian Xu et autres

Transcription factor (TF) networks are pivotal regulators of stem/progenitor cell fate. However, the regulatory mechanisms mediated by key TFs in adult periosteal stem/progenitor cells (PSPCs) remain poorly understood, impeding targeted therapies development for craniofacial bone regeneration. By integrating an analysis of regeneration-related, …

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Cell-specific gene expression plasticity in response to hypoxia promotes high-altitude adaptive evolution

Wen-Tian Wei, Ze Yan, Hui Wu, Mingliang Zhou et autres

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Harnessing energy metabolism for enhanced bone defect repair: mechanisms and therapeutic strategies

J.M. Li, Yulan Liu, Yuran Li, Yingjie Hua et autres

Bone defect repair remains a significant challenge in clinical orthopedics, primarily due to the limitations of traditional techniques, such as insufficient osteogenic efficiency and non-functional bone regeneration. Recently, the regulation of energy metabolism has emerged as a promising avenue for bone regeneration. …

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Native and engineered exosome-based approaches for oral and maxillofacial tissue regeneration: Present and future

Yuran Li, Yingjie Hua, Yixin Wang, Han Qiao et autres

Harnessing Energy Metabolism for Enhanced Bone Defect Repair: Mechanisms and Therapeutic Strategies

Junting Li, Yulan Liu, Yuran Li, Yingjie Hua et autres

Bone defect repair remains a significant challenge in clinical orthopedics, primarily due to the limitations of traditional techniques, such as insufficient osteogenic efficiency and non-functional bone regeneration. Recently, the regulation of energy metabolism has emerged as a promising avenue for bone regeneration. …

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Dual Micromechanical Interlocking Through Filler Surface Modification for Enhanced Dental Composites

Hongyan Chen, Jiaxuan Lyu, Jia-Cai Nie, Xuhui Wang et autres

A novel structure-functional-integrated particle featuring dual micromechanical interlocking property with resin matrix was constructed through surface modification of urchin-like serried hydroxyapatite (UHA) in this work, and the effect of this modification strategy on physicochemical and biological properties of dental resin composite was …

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Programmed BRD9 Degradation and Hedgehog Signaling Activation via Silk‐Based Core‐Shell Microneedles Promote Diabetic Wound Healing

Yili Liu, Mingliang Zhou, Jinrui Sun, Enhui Yao et autres

Wound healing impairment in diabetes mellitus is associated with an excessive inflammatory response and defective regeneration capability with suppressed Hedgehog (Hh) signaling. The bromodomain protein BRD9, a subunit of the non-canonical BAF chromatin-remodeling complex, is critical for macrophage inflammatory response. However, whether …

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Self-cascade ROS-trapping bioreaction system reverses stem cell oxidative stress fate for osteogenesis

Jiawei Yang, Hao Gu, Yuhui Zhu, Jiaojiao Shao et autres

Reactive oxygen species (ROS) scavenging is essential for periodontal regeneration. However, the dynamic change of the applied materials within the ROS-rich environment and the residual oxidation products in the host highly impact periodontal regeneration. This study successfully constructs a bioreaction system via …

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ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis

Jiahui Du, Yili Liu, Jinrui Sun, Enhui Yao et autres

Chromatin remodeler ARID1A regulates gene transcription by modulating nucleosome positioning and chromatin accessibility. While ARID1A-mediated stage and lineage-restricted gene regulation during cell fate canalization remains unresolved. Using osteoclastogenesis as a model, we show that ARID1A transcriptionally safeguards the osteoclast (OC) fate canalization …

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A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

Ze Yan, Ji Hyun Yang, Wen-Tian Wei, Mingliang Zhou et autres

High-altitude hypoxia acclimatization requires whole-body physiological regulation in highland immigrants, but the underlying genetic mechanism has not been clarified. Here we use sheep as an animal model for low-to-high altitude translocation. We generate multi-omics data including whole-genome sequences, time-resolved bulk RNA-Seq, ATAC-Seq …

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High‐Performance Hydrogel‐Encapsulated Engineered Exosomes for Supporting Endoplasmic Reticulum Homeostasis and Boosting Diabetic Bone Regeneration (Adv. Sci. 17/2024)

Yulan Liu, Sihan Lin, Zeqian Xu, Yuqiong Wu et autres

Diabetic Bone Regeneration Inspired by the correlation between endoplasmic reticulum (ER) dysfunction and osteogenesis disorder, Yulan Liu, Mingliang Zhou, Xinquan Jiang, and co-workers propose in article number 2309491 a novel therapeutic platform comprising a high-performance hydrogel and engineered exosomes to maintain ER …