Nancy Sherman

Anger Reinstated

Nancy Sherman

The question explored in this chapter is this: Is there a foothold, or even a toehold, in Stoic and Kantian texts that gives us purchase for developing an account of moral anger? I answer “yes,” although the positive argument in both Stoic …

A phase 1b/2 trial of onvansertib in combination with NALIRIFOX for first line treatment of advanced pancreatic cancer (PANCONVA trial).

Anup Kasi, Raed Moh’d Taiseer Al-Rajabi, Fairooz F. Kabbinavar, Nancy Sherman et autres

TPS4229 Background: Pancreatic cancer is a highly lethal disease. Despite research and drug development efforts focused on KRAS, no effective RAS inhibitors have been approved for the treatment of pancreatic cancer with KRAS mutation. PLK1 inhibition is a potential target in KRAS-mutated …

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Retrospective study evaluating safety, clinical effect, and dosing of dalteparin for the treatment of venous thromboembolism in term neonates

Nancy Sherman, Muhammad Younus, Kevin D. Wolter, Suresh Victor et autres

BACKGROUND: There is an increased risk of venous thromboembolism (VTE) among neonates due to their unique hemostatic system. However, there is lack of approved treatment options for VTE in neonatal population. Importantly, dalteparin, a low molecular weight heparin approved for pediatric VTE …

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Abstract CT275: A phase 2, randomized, open-label study of onvansertib in combination with standard-of-care (SoC) versus SoC alone for first-line treatment of RAS-mutant metastatic colorectal cancer (mCRC)

Heinz‐Josef Lenz, Benjamin Kuritzky, Anu Thummala, Stephan Kendall et autres

Abstract Background: Chemotherapy in combination with bevacizumab (Bev) has been a standard first-line treatment for RAS-mutated mCRC patients for the last 2 decades. The prognosis of these patients remains poor. Onvansertib is an orally available, highly potent, and selective inhibitor of Polo-like …

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Trauma Curriculum Integration in Counselor Education: A Delphi Study

Jaimee York, Adrienne Baggs, Laura Schmuldt, Nancy Sherman

Research has established the need for trauma education and training for safe and effective entry-level practice. However, studies have shown insufficient and inconsistent training in graduate counseling programs. Those studies reflected the opinions and experiences of practitioners and graduate students. To add …

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Safety of Intravenous Pantoprazole Sodium in Pediatric Patients Aged 1 Month to < 1 Year: A Real-World Retrospective Cohort Study

Sampada Gandhi, Benjamin Taylor, Lexie Rubens, Nileesa Gautam et autres

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The Look and Feel of Moral Injury

Nancy Sherman

Abstract Philosophers usefully talk about the emotions that constitute a sense of moral accountability in terms of “reactive attitudes.” These include, on the negative side, guilt, shame, and moral disappointment toward self, resentment or moral disappointment and distrust toward others, and on …

Stoics on Stuff

Nancy Sherman

Abstract The ancient Stoics force us to rethink our attachment to cultural objects and our valuation of them as a central part of flourishing. Pushing the Socratic view to an extreme, they hold that virtue alone is sufficient for happiness. External goods, …

Stoic Grit, Moral Injury, and Resilience

Nancy Sherman

There is a tension in military culture between the growing acceptance of moral injury and an idealized view of Stoicism that leaves little room for the guilt and shame, mercy and forgiveness characteristic of moral injury and repair. Does that emotion-lean view …

Setting the Stage for Climate Action Under the Montreal Protocol

Stephen O. Andersen, Nancy Sherman

Twelve papers formed the scientific basis for fast action to strengthen the treaty, which was already safeguarding stratospheric ozone, so it also protects the climate by reducing super pollutants.

A phase 2 pharmacodynamic dose‐finding, safety, and efficacy study of dalteparin for pediatric venous thromboembolism treatment in children with and without cancer

Lisa R. Hartman, Ildar Nurmeev, Pavel Svirin, Kevin D. Wolter et autres

Data from registrational trials of pediatric venous thromboembolism (VTE) treatment are sparse, especially among cancer patients. We conducted a prospective, multicenter, open-label trial (NCT00952380) on dose-finding, safety, and efficacy (measured by 90-day risks of clinically relevant bleeding [CRB] and symptomatic recurrent VTE …

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Shame & Guilt: From Deigh to Strawson & Hume, and now to the Stoics

Nancy Sherman

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