Hongqin Ke

Development and validation of a risk prediction model for meropenem-related thrombocytopenia in patients with pulmonary infection

Xiao Wang, Hongqin Ke, Jianyong Zhu, Lijun Zhao et autres

OBJECTIVE: The prevalence of meropenem-related thrombocytopenia has risen in tandem with the growing utilization of meropenem in clinical settings. Consequently, we aimed to develop a risk prediction model for meropenem-related thrombocytopenia in patients with pulmonary infection and to enhance the safety for …

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Construction and validation of a meropenem-induced liver injury risk prediction model: a multicenter case-control study

He Yan, Hongqin Ke, Jianyong Zhu, Xin Yuan et autres

Objective To construct and validate a risk prediction model for patients with meropenem-induced liver injury (MiLI). Methods A retrospective case-control study was conducted to collect data on inpatients treated with meropenem at Shiyan People’s Hospital, Hubei, China from January 2018 to December …

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Selective Adsorption of Human Testosterone from Plasma Using Zn2+-Loaded Hexanediamine–Chitosan Beads

Huibin Yu, Hongqin Ke, Chen Tu, Jia Ming Huang et autres

High Resolution Image Download MS PowerPoint Slide This study aimed to develop a novel adsorbent, Zn 2 + -loaded hexanediamine–chitosan (HDA-CS) beads, for the selective removal of human testosterone from plasma. The preparation involved synthesizing chitosan beads, modifying them with hexanediamine to …

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The safety and economic evaluation of bevacizumab and PD-1 inhibitors for advanced non- squamous NSCLC: a multicenter observational study in China

Min Hu, Changdong Diao, Jinmei Liu, Xiong Wang et autres

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An LC-MS/MS method for the simultaneous determination of 18 antibacterial drugs in human plasma and its application in therapeutic drug monitoring

Wei Lu, Meng Hua Pan, Hongqin Ke, Jun Sheng Liang et autres

Antimicrobial resistance (AMR) is a major threat to global health due to the wide use of antibacterial drugs. Multiple studies show that the pharmacokinetic/pharmacodynamic (PK/PD) studies of antibiotics are an approach to prevent/delay AMR. The pharmacokinetic parameters of antibiotics are the basis …

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Zn2+-loaded cellulose beads stabilized by chitosan and prepared via freeze-drying for removing human testosterone in plasma

Huibin Yu, Hongqin Ke, Tu Chen, Xing Li et autres

Hemoperfusion using metal ion affinity adsorbent is a promising method to remove human testosterone in plasma. Due to the leakage of metal ion from the adsorbents, there is no metal ion affinity adsorbent for hemoperfusion. In this study, chitosan was used to …

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Zn2+-Loaded Cellulose Beads Stabilized by Chitosan and Prepared via Freeze-Drying for Removing Human Testosterone in Plasma

Huibin Yu, Hongqin Ke, Chen Tu, Xing Li et autres

Immobilized metal ion affinity adsorbents have been widely used in separation technique to purify proteins. Due to the leakage of metal ion from the adsorbents, there is no metal ion affinity adsorbent for hemoperfusion has been applied to clinical trial. In this …

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