Haiyang Guo

Pioneer transcription factors direct tissue-specific cohesin chromatin entry and three-dimensional genome organization

Song Wang, Xianglin Zhang, Tianwei Jia, Wenzheng Wang et autres

cn, ca (code pays fourni par la source)

ARID1A terminates gastric regeneration to prevent cancer

Adrian K.H. Loe, Alyssa Ialongo, Yan Qin, Amin Afkhami-Poostchi et autres

ca, jp, cn (code pays fourni par la source)

The individual and combined effects of air pollution mixtures on the risk of cardiovascular diseases in patients with Cardiovascular-Kidney-Metabolic syndrome at stages 0–3

Fengjiao Han, Haiyang Guo, Yang Zheng

BACKGROUND: This study aims to employ a prospective cohort design to quantitatively assess the association between exposure levels of common ambient air pollutants and the risk of cardiovascular disease (CVD) in patients across stages 0-3 of Cardiovascular-kidney-metabolic (CKM) syndrome. By doing so, …

cn (code pays fourni par la source)

Comprehensive protocols for H1-10 nucleolar functional characterization v1

Xiaoyu Liu, Wenzheng Wang, Xianglin Zhang, Haiyang Guo

This unified protocol documents a set of wet-lab experiments and bioinformatic analytical pipelines. Independent sections cover cell functional assays, lentiviral and fusion plasmid construction, in vitro protein purification and phase separation, immunoprecipitation and chemoproteomics, nucleolar distribution measurement, compound screening, tissue microarray analysis, …

cn (code pays fourni par la source)

The gastrin-releasing peptide receptor in oncology: a comprehensive review of recent advances in targeted radionuclide theranostics

YunLong Yang, Jiang Fu, ShengJie Tang, Tao Liu et autres

The gastrin-releasing peptide receptor (GRPR) is aberrantly expressed in several malignancies, including prostate cancer, breast cancer, lung cancer, and gastrointestinal stromal tumors, making it an important target for molecular imaging and targeted radionuclide therapy. In recent years, advances in radioligand design, radionuclide …

cn (code pays fourni par la source)

GFPT2 upregulation predicts poor prognosis and is associated with TGF-β/Smad activation in lung adenocarcinoma

Zixu Wang, Jiang Fu, ShengJie Tang, Gang Qiu et autres

BACKGROUND: Glutamine-fructose-6-phosphate amidotransferase 2 (GFPT2) is a rate-limiting enzyme of the hexosamine biosynthetic pathway, but its protein-level expression and functional relevance in lung adenocarcinoma (LUAD) remain unclear. METHODS: GFPT2 protein abundance was evaluated in Clinical Proteomic Tumor Analysis Consortium (CPTAC) LUAD proteomics …

cn (code pays fourni par la source)

Development and external validation of a machine learning–based Cox model for predicting in-hospital survival in classic heatstroke: a multicenter retrospective study

Donglin Li, Xinyi He, Yanlin Zhou, Fake Liu et autres

Classical heatstroke (CHS) is a life-threatening condition necessitating accurate prognostic tools for risk stratification. The potential of machine learning to predict clinical outcomes in CHS remains largely unexplored. Our objective was to develop and externally validate machine learning-based Cox model for predicting …

cn (code pays fourni par la source)

Advances in neurotensin receptor 1-targeted molecular probes for tumor molecular imaging and therapy

Chengkuan Liu, Jiang Fu, ShengJie Tang, Haiyang Hu et autres

Neurotensin receptor 1 (NTS1) is a high-affinity G protein-coupled receptor (GPCR) for the endogenous peptide neurotensin (NT). NTS1 is overexpressed across multiple malignancies and is an important target for precision theranostics. In recent years, NTS1-targeted molecular probes have advanced considerably, improving the …

cn (code pays fourni par la source)

Nuclear factor erythroid 2-related factor 2 gene expression in patients with heat stroke and its association with oxidative stress and inflammation: a prospective study

Guodong Lin, Haiyang Guo, Bingling Yin, Chongxiao Xu et autres

Introduction Heat strokes represent a critical health issue with high mortality when severe, yet treatments are limited and do not target core pathogenic mechanisms. Oxidative stress is instrumental in heat stroke progression and is closely related to inflammatory activation and endothelial damage. …

cn, ph (code pays fourni par la source)

Radionuclide theranostics: advances and clinical applications in lung cancer

Yang Yang, Jiang Fu, ShengJie Tang, Tao Liu et autres

Lung cancer remains a leading cause of global cancer deaths, underscoring the urgent need for more accurate diagnostic and treatment approaches. Radionuclide theranostics has rapidly emerged as a paradigm that couples molecular imaging with targeted internal irradiation, enabling personalized cancer care. This …

cn (code pays fourni par la source)

Predictive performance of the SOFA 2.0 score for in-hospital mortality in patients with heat stroke: a multicenter, data-driven subphenotype study

Haoming Luo, Yirui Zhu, Ruoman Wang, Weihua Li et autres

Objective: Heat stroke can progress rapidly, and the risk of in-hospital mortality increases once multiple organ dysfunction develops. Early risk stratification is therefore clinically important, yet comparative evidence across commonly used severity scores in heat stroke remains limited. Methods: We conducted a …

cn, in (code pays fourni par la source)

Role of NRF2 in regulating oxidative stress and alleviating mitochondrial and endoplasmic reticulum structural damage in heatstroke-induced brain injury

Bingling Yin, Haiyang Guo, Yu Shao, Chongxiao Xu et autres

This preliminary research shows that the NRF2 antioxidant signaling pathway exerts a protective effect against oxidative stress, mitigating both mitochondrial and ER structural damage in neuronal cells during heatstroke. Therefore, targeting the NRF2 pathway is a promising therapeutic strategy for heatstroke-induced neuronal …

cn (code pays fourni par la source)