Louis‐Jacques Ruel

LIVER CONCENTRATIONS OF THE LONG NON-CODING RNA TRIB1AL ARE ASSOCIATED WITH INCIDENT STEATOTIC LIVER DISEASE AND CORONARY ARTERY DISEASE

Émilie Gobeil, Manel Dahmene, Louis‐Jacques Ruel, Arnaud Girard et autres

DEVELOPMENT OF A SEX-SPECIFIC LIFETIME PREDICTION MODEL FOR OPTIMAL PREDICTION OF CORONARY ARTERY DISEASE RISK AND PERSONALIZED PREVENTIVE TREATMENTS

Louis‐Jacques Ruel, Audrey Paulin, Arnaud Girard, Sébastien Thériault et autres

CONTRIBUTIONS OF LIPOPROTEIN(A) LEVELS AND AN AORTIC STENOSIS POLYGENIC RISK SCORE TO VALVULAR AND CARDIOVASCULAR EVENTS IN PARTICIPANTS WITH AORTIC STENOSIS

Arnaud Girard, Louis‐Jacques Ruel, Sébastien Thériault, Benoît Arsenault

ESTIMATING THE SEX-SPECIFIC EFFECTS OF INCREASED PHYSICAL ACTIVITY ON THE INCIDENCE OF CARDIOVASCULAR DISEASE IN THE GENERAL POPULATION

Audrey Paulin, Louis‐Jacques Ruel, Benoît Arsenault

An integrated proteogenomic investigation of the human liver uncovers molecular drivers of steatotic liver disease

Émilie Gobeil, Jérôme Bourgault, Malie Enault, Valérie Côté et autres

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly increasing worldwide, yet effective targeted therapies remain limited. To better understand the molecular mechanisms underlying MASLD, we performed an integrated proteogenomic analysis of human liver tissue. Using mass spectrometry, we quantified 2,744 proteins …

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Sex-specific associations of social determinants of health and genetic risk factors with atherosclerotic cardiovascular diseases incidence in the general population

Audrey Paulin, Louis‐Jacques Ruel, Sébastien Thériault, Benoit J. Arsenault

The combined contribution of social determinants of health (SDOH) that includes socioeconomic status, psychosocial factors and living environment and genetic background on atherosclerotic cardiovascular disease (ASCVD) risk remains unknown. We investigated the contribution of a polysocial risk score (PSS) and polygenic risk …

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Supplementary materials - Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease

Émilie Gobeil, Jérôme Bourgault, Éloi Gagnon, Nolwenn Samson et autres

Supplementary materials for the publication Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease. PMID: 41635218 Reference: J Clin Endocrinol Metab. 2026 Feb 4:dgag043. doi: 10.1210/clinem/dgag043.

Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease

Émilie Gobeil, Jérôme Bourgault, Éloi Gagnon, Nolwenn Samson et autres

CONTEXT: Genome-wide association studies (GWAS) have identified dozens of genetic loci linked with metabolic dysfunction-associated steatotic liver disease (MASLD). OBJECTIVE: To identify liver-expressed genes that may represent therapeutic candidates for MASLD. METHODS: We conducted a new GWAS meta-analysis including 16 532 cases …

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Supplementary materials - Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease

Émilie Gobeil, Jérôme Bourgault, Éloi Gagnon, Nolwenn Samson et autres

Supplementary materials for the publication Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease. PMID: 41635218 Reference: J Clin Endocrinol Metab. 2026 Feb 4:dgag043. doi: 10.1210/clinem/dgag043.

P262 JOINT ASSOCIATIONS OF SOCIAL DETERMINANTS OF HEALTH AND GENETIC RISK FACTORS ON ISCHEMIC STROKE INCIDENCE

A. Paulin, Louis‐Jacques Ruel, Sébastien Thériault, Benoît Arsenault

Sex-specific associations of social determinants of health and genetic risk factors with atherosclerotic cardiovascular diseases incidence in the general population

Audrey Paulin, Louis‐Jacques Ruel, Sébastien Thériault, Benoît J. Arsenault

Abstract Background and aims The combined contribution of polysocial risk factors (socioeconomic status, psychosocial factors and living environment) and genetic background on atherosclerotic cardiovascular disease (ASCVD) risk remains unknown. We investigated the contribution of a comprehensive polysocial risk score (PsRS) and polygenic …

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The long non-coding RNA TRIB1AL links metabolic dysfunction-associated steatotic liver disease, cardiometabolic risk and human lifespan

Émilie Gobeil, Jérôme Bourgault, Éloi Gagnon, Nolwenn Samson et autres

Abstract Genome-wide association studies (GWAS) have identified dozens of genetic loci linked with metabolic dysfunction-associated steatotic liver disease (MASLD). To identify liver-expressed genes that may represent therapeutic candidates for MASLD, we conducted a new GWAS meta-analysis including 16,532 cases and 1,240,188 controls, …

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