Mélanie Desancé

Evaluation of Allogeneic Bone-Marrow-Derived and Umbilical Cord Blood-Derived Mesenchymal Stem Cells to Prevent the Development of Osteoarthritis in An Equine Model

Lélia Bertoni, Sandrine Jacquet-Guibon, Thomas Branly, Mélanie Desancé et autres

Osteoarthritis (OA) is a significant cause of pain in both humans and horses with a high socio-economic impact. The horse is recognized as a pertinent model for human OA. In both species, regenerative therapy with allogeneic mesenchymal stem cells (MSCs) appears to …

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An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: Technical, clinical, imaging, biochemical, macroscopic and microscopic characterization

Lélia Bertoni, Sandrine Jacquet-Guibon, Thomas Branly, Florence Legendre et autres

Osteoarthritis is a common cause of pain and economic loss in both humans and horses. The horse is recognized as a suitable model for human osteoarthritis, because the thickness, structure, and mechanical properties of equine articular cartilage are highly comparable to those …

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Comparison of the Chondrogenic Potential of Mesenchymal Stem Cells Derived from Bone Marrow and Umbilical Cord Blood Intended for Cartilage Tissue Engineering

Romain Contentin, Magali Demoor, Miranda Concari, Mélanie Desancé et autres

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Intra-Articular Injection of 2 Different Dosages of Autologous and Allogeneic Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cells Triggers a Variable Inflammatory Response of the Fetlock Joint on 12 Sound Experimental Horses

Lélia Bertoni, Thomas Branly, Sandrine Jacquet, Mélanie Desancé et autres

Osteoarthritis is a significant and costly cause of pain for both humans and horses. The horse has been identified as a suitable model for human osteoarthritis. Regenerative therapy with allogeneic mesenchymal stem cells (MSCs) is a promising treatment, but the safety of …

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Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy

Mélanie Desancé, Romain Contentin, Lélia Bertoni, Tangni Gómez-Leduc et autres

Cartilage engineering is a new strategy for the treatment of cartilage damage due to osteoarthritis or trauma in humans. Racehorses are exposed to the same type of cartilage damage and the anatomical, cellular, and biochemical properties of their cartilage are comparable to …

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Improvement of the Chondrocyte-Specific Phenotype upon Equine Bone Marrow Mesenchymal Stem Cell Differentiation: Influence of Culture Time, Transforming Growth Factors and Type I Collagen siRNAs on the Differentiation Index

Thomas Branly, Romain Contentin, Mélanie Desancé, Thibaud Jacquel et autres

Articular cartilage is a tissue characterized by its poor intrinsic capacity for self-repair. This tissue is frequently altered upon trauma or in osteoarthritis (OA), a degenerative disease that is currently incurable. Similar musculoskeletal disorders also affect horses and OA incurs considerable economic …

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Comparison of the chondrogenic potential of mesenchymal stem cells derived from bone marrow and umbilical cord blood intended for cartilage tissue engineering

Romain Contentin, Thomas Branly, Julien Pestel, Miranda Concari et autres

Enhanced chondrogenesis of bone marrow-derived stem cells by using a combinatory cell therapy strategy with BMP-2/TGF-β1, hypoxia, and COL1A1/HtrA1 siRNAs

Thomas Branly, Romain Contentin, Mélanie Desancé, Thibaud Jacquel et autres

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Hypoxia Is a Critical Parameter for Chondrogenic Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells in Type I/III Collagen Sponges

Tangni Gómez-Leduc, Mélanie Desancé, Magalie Hervieu, Florence Legendre et autres

Umbilical cord blood (UCB) is an attractive alternative to bone marrow for isolation of mesenchymal stem cells (MSCs) to treat articular cartilage defects. Here, we set out to determine the growth factors (bone morphogenetic protein 2 (BMP-2) and transforming growth factor-β (TGF-β1)) …

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Characterization and use of Equine Bone Marrow Mesenchymal Stem Cells in Equine Cartilage Engineering. Study of their Hyaline Cartilage Forming Potential when Cultured under Hypoxia within a Biomaterial in the Presence of BMP-2 and TGF-ß1

Thomas Branly, Lélia Bertoni, Romain Contentin, Rodolphe Rakic et autres

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Nouvelles stratégies thérapeutiques des affections articulaires : évaluation du potentiel des cellules souches de sang de cordon ombilical : vers l'industrialisation de cellules médicaments en santé équine

Mélanie Desancé

Le cheval athlete est expose a des lesions degeneratives ou traumatiques du cartilage predisposant au developpement de l’arthrose. Les arthropathies associees a une degradation du cartilage se traduisent par une perte de fonctionnalite de l’articulation. Le cartilage ne possedant que de tres …

New therapeutic strategies for joint disorders : evaluation of the potential of umbilical cord blood stem cells : towards industrialization of medicines cells in equine health

Mélanie Desancé

Le cheval athlète est exposé à des lésions dégénératives ou traumatiques du cartilage prédisposant au développement de l’arthrose. Les arthropathies associées à une dégradation du cartilage se traduisent par une perte de fonctionnalité de l’articulation. Le cartilage ne possédant que de très …