Satoshi Asano

Residential mobility as a contextual factor undermining social norms for cooperation: Multilevel analyses of community data in Japan

Kosuke Takemura, Shintaro Fukushima, Yukiko Uchida, Satoshi Asano et autres

Social norms sustain community cooperation through sanctions against free riders. However, previous studies have argued that norms are ineffective for individuals who often relocate, because ostracism, a form of sanction, is not a threat to them. In addition to this individual-level effect, …

Predicting OCT2 / MATEs ‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini et autres

Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the K i values for OCT2 exhibit substrate dependency and …

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Evaluation of Rural Revitalization Activities using the Most Significant Change Technique and Its Multifaceted Impacts

Minori TOKITO, Satoshi Asano, Izuru Saizen

The continuity of collaborative activities and the deepening of participants' understanding are important to implementing meaningful transdisciplinary research. In recent years, transdisciplinary frameworks have become relevant in various research fields, and the rural planning study has accumulated many cases of regional collaborative …

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On the Symposium “Concept of Integrated Approaches to Testing and Assessment (IATA) Using New Approach Methods (NAMs) —Learning from the Study of Thyroid Hormone System and Developmental Neurotoxicity—”

Shigeki Yamamoto, Satoshi Asano, Tomotaka Sobue, Masahiro Tohkin

Food Safety Commission of Japan (FSCJ) hosted a symposium entitled "Concept of Integrated Approaches to Testing and Assessment (IATA) Using New Approach Methods (NAMs) -Learning from the Study of Thyroid Hormone System and Developmental Neurotoxicity-" to deepen our understanding on the application …

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Prediction of Inhibitory Activity against the MATE1 Transporter via Combined Fingerprint- and Physics-Based Machine Learning Models

Koichi Handa, Shunta Sasaki, Satoshi Asano, Michiharu Kageyama et autres

High Resolution Image Download MS PowerPoint Slide Renal secretion plays an important role in excretion of drug from the kidney. Two major transporters known to be highly involved in renal secretion are MATE1/2 K and OCT2, the former of which is highly …

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A double-blind, placebo-controlled, randomized multiple dose phase 1b trial of a CDK4/6 inhibitor, TCK-276, in patients with active rheumatoid arthritis

Daisuke Tasaki, Kazuoki Tsuruda, Shosho Sun, Yoshinori Tsumura et autres

OBJECTIVE: The purpose of this study was to evaluate the safety, tolerability, pharmacokinetics and efficacy (as an exploratory endpoint) of TCK-276, a novel CDK4/6 inhibitor, after multiple oral doses for 7 days in patients with active RA. METHODS: This multicentre, randomized, placebo-controlled, …

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Prediction of Inhibitory Activity Against the MATE1 Transporter via Combined Fingerprint- and Physics-Based Machine Learning Models

Koichi Handa, Shunta Sasaki, Satoshi Asano, Michiharu Kageyama et autres

Renal secretion plays an important role in drug excretion from the kidney. Two major transporters known to be highly involved in renal secretion are MATE1/2-K and OCT2, the former of which is highly related to drug-drug interactions. Among published in silico models …

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On the Commemorative Ceremony and Symposium for the 20th Anniversary of Food Safety Commission, Cabinet Office, Government of Japan

Shigeki Yamamoto, Satoshi Asano, Toru Kawanishi, Masako Waki

anniversary at Mita conference hall (Mita, Minato-ku, Tokyo) on September 1st, 2023, which attracted a total of 164 on-site attendees including six media companies, as well as 460 online viewers. FSCJ Chairperson Dr. YAMAMOTO gave a summary of each session; Session 1 …

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Analyzing Household-Level Insect Farming as a Component of Livelihood Diversification

Satoshi Asano, Chananat KAEWMANEE, Izuru Saizen

With growing interest in entomophagy (the practice of eating insects) as a new eco-friendly alternative protein, household-level and small-scale insect farming is expanding in Thailand, a country with rich entomophagy culture. However, few studies have assessed the value of insect farming in …

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Quantitative prediction of transporter-mediated drug-drug interactions using the mechanistic static pharmacokinetic (MSPK) model

Satoshi Asano, Chie Kurosaki, Yuko Mori, Ryota Shigemi

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Integrated Use of In Vitro and In Vivo Information for Comprehensive Prediction of Drug Interactions Due to Inhibition of Multiple CYP Isoenzymes

Shizuka Hozuki, Hideki Yoshioka, Satoshi Asano, Mikiko Nakamura et autres

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Nature and Happiness Levels: New SWB Domains for Rivers, a Lake, and Forests

Takuya Takahashi, Satoshi Asano, Yukiko Uchida, Kosuke null Takemura et autres

By using a questionnaire survey, we measured nature-related happiness levels, which include specific domains that differ from the overall subjective well-being (SWB) in a Japanese watershed. We regarded nature-related happiness levels, specifically related to rivers, a lake, or forests, as meaningful indices …