Abigail L. Hay

Rutter et al_Supplementary Data Set 3: Figs. 6b,6d,S11f_Ortiz

Ben Rutter, Michael Herrera, Gustavo Pérez-Ortíz, Claudio Greco et autres

Raw data files from MyrA protein purification and comparison of reaction outputs between the MyrA protein and differing combinations and concentrations of Acyl CoAs and aminomalonate or L-serine.

Rutter et al_Supplementary Data Set 3: Figs. 6b,6d,S11f_Ortiz

Ben Rutter, Michael Herrera, Gustavo Pérez-Ortíz, Claudio Greco et autres

Raw data files from MyrA protein purification and comparison of reaction outputs between the MyrA protein and differing combinations and concentrations of Acyl CoAs and aminomalonate or L-serine.

Cattle antibodies identify a cross-serotype broadly neutralising foot-and-mouth disease virus epitope

Marie Bonnet‐Di Placido, Helen M. E. Duyvesteyn, Angela Steyn, Abigail L. Hay et autres

Abstract Foot-and-mouth disease virus (FMDV) causes a devastating disease that threatens global food security. Vaccination is hindered by antigenic diversity across serotypes. To identify cross-serotype neutralising epitopes, we isolated 24 FMDV-specific antibodies from cattle sequentially vaccinated with antigens from four serotypes, of …

gb, ca, nl (code pays fourni par la source)

Evolution, structure and function of the biosynthetic gene cluster of myriocin, a potent inhibitory sphingolipid

Alexandra Brand, Ben Rutter, Michael B. Herrera, Gustavo Pérez-Ortíz et autres

gb, us, fr (code pays fourni par la source)

Understanding the future risk of bat coronavirus spillover into humans – correlating sarbecovirus receptor usage, host range, and antigenicity

Nazia Thakur, Joseph Newman, Dongchun Ni, Jeffrey Seow et autres

Abstract Sarbecoviruses interact with their receptor, angiotensin converting enzyme 2 (ACE2), via the receptor binding domain (RBD) of Spike, the immunodominant target for neutralising antibodies. Understanding the interplay and correlation between ACE2-determined host range and antigenicity is vitally important for understanding the …

gb, cn, ch (code pays fourni par la source)

Development of bovine IgG3-specific assays using a novel recombinant single-domain binding reagent

Alistair Noble, Ellen C. Moorhouse, Abigail L. Hay, Basudev Paudyal et autres

Cattle express three subclasses of IgG antibody - IgG1, IgG2 and IgG3. Unlike IgG1 and IgG2, IgG3 was described relatively recently and the role of this subclass in immunity is unknown. Using recombinant bovine IgG1, IgG2 and IgG3 monoclonal antibodies (mAbs), we …

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A broadly reactive ultralong bovine antibody that can determine the integrity of foot-and-mouth disease virus capsids

John Clarke, Helen M. E. Duyvesteyn, Eva Pérez-Martín, Undīne Latišenko et autres

Foot-and-mouth disease vaccination using inactivated virus is suboptimal, as the icosahedral viral capsids often disassemble into antigenically distinct pentameric units during long-term storage, or exposure to elevated temperature or lowered pH, and thus raise a response that is no longer protective. Furthermore, …

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Cattle killer immunoglobulin-like receptor expression on leukocyte subsets suggests functional divergence compared to humans

Abigail L. Hay, J.R. Birch, Shirley A. Ellis, Daniel Burns et autres

Cattle, sheep, and goats are the only species outside primates known to have an expanded and diversified family of killer immunoglobulin-like receptors (KIR). Primate KIR are expressed on the surface of NK and T cells and bind MHC-I to control activation. However, …

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Optimization of RNA extraction from laser captured microdissected glomeruli from formalin-fixed paraffin-embedded mouse kidney samples for Nanostring analysis.

Abigail L. Hay, Jean‐Martin Lapointe, Arthur Lewis, Carol Moreno Quinn et autres

Optimized protocols for the microdissection of specific areas from archival tissues and the subsequent RNA analysis are needed but challenging due to RNA degradation and chemical modifications. The aim of this study was to present the most appropriate protocol for utilizing mouse …

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