Archna Panghal

Role of Systems Biology in Drug Discovery and Repurposing

Ashima Thakur, Radha Shree Bhattacharya, Archna Panghal, Lachhman Singh et autres

Crosstalk between copper, Alzheimer’s disease, and melatonin

Deepika, Ashima Thakur, Archna Panghal, R. K. Pundir et autres

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TDP-43 Proteinopathies in ALS and FTLD: Mechanistic Insights andTherapeutic Approaches

Shilpi Chauhan, Preeti Maan, Archna Panghal

TAR DNA-binding protein 43 (TDP-43) is a vital RNA/DNA-binding protein involved in RNA metabolism, playing a key role in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Approximately 97% of sporadic ALS (sALS), familial ALS (fALS) and FTLD …

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Dimethyl Fumarate Protects Diabetes‐Induced Testicular Toxicity in Rats: Investigations on Nrf‐2/HO‐1 and β‐Catenin/OCT‐4 Signalling Pathways

Archna Panghal, Vinod Kumar, Gopabandhu Jena

Type 1 Diabetes Mellitus (T1DM) is associated with the destruction of insulin-producing β-cells and is characterized by prolonged hyperglycemia. This can increase oxidative stress which eventually damages the male reproductive system, disturbs the production of testosterone, alters semen quality and histological architecture, …

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The intervention of NLRP3 inflammasome inhibitor: oridonin against azoxymethane and dextran sulfate sodium–induced colitis-associated colorectal cancer in male BALB/c mice

Gurpreet Kaur, Priyanka Tiwari, Shivani Singla, Archna Panghal et autres

Colorectal cancer (CRC) ranks third globally in cancer diagnoses. The dysregulation of the NLRP3 inflammasome is prominently linked to several types of cancers. Oridonin, a principal component of Rabdosia rubescens, exhibits inhibitory activity against NLRP3 and is well-recognized for its diverse pharmacological …

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Multi‐Targeting Phytochemicals for Alzheimer's Disease

Radha Shree Bhattacharya, Raghuraj Singh, Archna Panghal, Ashima Thakur et autres

Alzheimer's disease (AD) is a type of neurodegenerative illness in which β-amyloid (Aβ) and tau protein accumulate in neurons in the form of tangles. The pathophysiological pathway of AD consists of Aβ-amyloid peptides, tau proteins, and oxidative stress in neurons and increased …

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Contributors

Krishn Kumar Agrawal, Bushra Urooj Ahmed, Ajay Pandey, Apurva Apurva et autres

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Nanotherapeutics in pulmonary infections

Sanchit Arora, Archna Panghal, Charan Singh

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Nano-based approaches for the treatment of neuro-immunological disorders: a special emphasis on multiple sclerosis

Archna Panghal, Swaran J.S. Flora

Multiple sclerosis (MS) is a neuroimmunological disorder which causes axonal damage, demyelination and paralysis. Although numerous therapeutics have been developed for the effective treatment of MS and a few have been approved in recent decades, complete remission and treatment of MS remain …

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β-aminoisobutyric acid ameliorated type 1 diabetes-induced germ cell toxicity in rat: Studies on the role of oxidative stress and IGF-1/AMPK/SIRT-1 signaling pathway

Archna Panghal, Gopabandhu Jena

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Recent Advances in Targeting Transition Metals (Copper, Iron, and Zinc) in Alzheimer’s Disease

Raghuraj Singh, Archna Panghal, Krishna Jadhav, Ashima Thakur et autres

Changes in the transition metal homeostasis in the brain are closely linked with Alzheimer's disease (AD), including intraneuronal iron accumulation and extracellular copper and zinc pooling in the amyloid plague. The brain copper, zinc, and iron surplus are commonly acknowledged characteristics of …

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Multimetal exposure: Challenges in diagnostics, prevention, and treatment

Archna Panghal, Ashima Thakur, Monika S. Deore, Manoj Goyal et autres

Extensive use of heavy metals has posed a serious concern for ecosystem and human too. Heavy metals are toxic in nature and their accumulation in human body causes serious disorders such as neurological disease, cardiac disease, gastrointestinal problems, skin disorders, reproductive disease, …

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