Neelesh Kumar Mehra

Development and evaluation of the bioinspired multi-stimuli-responsive trilayer core-shell hybrid nanospheres for delivering a synergistic anticancer therapeutic delivery in breast cancer management

Rajeshwari Deshmukh, Naveen Rajana, Ravindra Vasave, Usha Nalla Kumari et autres

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Electrostatically engineered fucoidan-coated liposomal oxaliplatin: In silico, 2D 3D, in vivo pharmacokinetic evaluations for colorectal cancer management

Rati Yadav, Ezhilmathe Athavan, Padakanti Sandeep Chary, Vaibhavi Srivastava et autres

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Repurposed Axitinib delivered via lipid-extruded PEGylated liposomes: 2D/3D breast cancer cell evaluation and in-vivo pharmacokinetics

Avinash Pawar, Ekta Pardhi, Sumedh Bahadure, Rati Yadav et autres

PEGylated liposomal nanocarriers have emerged as a promising drug delivery platform for improving the pharmacokinetic performance and systemic circulation of poorly water-soluble anticancer drugs. In this study, Axitinib-loaded PEGylated liposomes (F11-PEGliposome) were prepared and evaluated for the potential treatment of breast cancer. …

Repurposed Axitinib delivered via lipid-extruded PEGylated liposomes: 2D/3D breast cancer cell evaluation and in-vivo pharmacokinetics

Avinash Pawar, Ekta Pardhi, Sumedh Bahadure, Rati Yadav et autres

PEGylated liposomal nanocarriers have emerged as a promising drug delivery platform for improving the pharmacokinetic performance and systemic circulation of poorly water-soluble anticancer drugs. In this study, Axitinib-loaded PEGylated liposomes (F11-PEGliposome) were prepared and evaluated for the potential treatment of breast cancer. …

in (code pays fourni par la source)

Repurposed Axitinib delivered via lipid-extruded PEGylated liposomes: 2D/3D breast cancer cell evaluation and in-vivo pharmacokinetics

Avinash Pawar, Ekta Pardhi, Sumedh Bahadure, Rati Yadav et autres

PEGylated liposomal nanocarriers have emerged as a promising drug delivery platform for improving the pharmacokinetic performance and systemic circulation of poorly water-soluble anticancer drugs. In this study, Axitinib-loaded PEGylated liposomes (F11-PEGliposome) were prepared and evaluated for the potential treatment of breast cancer. …

Integrated analytical characterization and multiscale modeling of supramolecular interactions in lumefantrine-curcumin coamorphous systems with enhanced biopharmaceutical and anticancer performance

Rahul Khemchandani, Ekta Pardhi, Ansari Muhammad Faizan, Priyanka Devi et autres

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Contributors

Md Imtiyaz Alam, Sumedh Bahadure, Anoothi Bain, J.P. Shabaaz Begum et autres

Multifunctional carbon based nanomaterials for drug delivery: Concept and mechanism

Sri Pada Datta Chigurupati, Nalla Usha Kumari, Sumedh Bahadure, Neelesh Kumar Mehra

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Mechanistic enhancement of oral bioavailability through a coamorphous apremilast-aceclofenac systems: integrated LC-MS/MS Bioanalysis, in vivo pharmacokinetics, and PBPK modeling

Rahul Khemchandani, Ekta Pardhi, Aditya Jadhav, Nadeem Shaikh et autres

in (code pays fourni par la source)

Development, validation and application of LC–MS/MS method for simultaneous determination of irinotecan and cyclosporine in co-loaded self-nanoemulsifying drug delivery system

Rati Yadav, Padakanti Sandeep Chary, Harshada Anil Bhalerao, Rajesh Sonti et autres

in (code pays fourni par la source)

Uveitis Management at the Crossroads of Pharmacotherapy, Nanotechnology, and Intellectual Property

Aayushi Pandey, Rohit Bhawale, Ravindra Vasave, Omar Khan et autres

Uveitis is a complex ocular inflammatory disorder that remains challenging to manage due to recurrent disease progression, limited drug bioavailability, and treatment-associated adverse effects. Conventional pharmacotherapy often fails to maintain therapeutic drug concentrations at target ocular tissues, necessitating frequent dosing or invasive …

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In Vitro and In Vivo Assessment of Darolutamide Encapsulated Lipid-Extruded PEGylated Liposomal Formulation

Ekta Pardhi, Rahul Khemchandani, Avinash Pawar, Ruchita Patil et autres

Darolutamide (DA), a non-steroidal androgen receptor inhibitor, has emerged as a promising therapeutic agent for non-metastatic castration-resistant prostate cancer (nmCRPC); however, its clinical utility is limited by poor aqueous solubility and the need for high therapeutic doses. To address these challenges, PEGylated …