Accès ouvert
2022
preprint
OpenAlex
Christian Wake, Julie A. Schneider, Thor D. Stein, Joli Bregu et autres
Abstract Obesity, the accumulation of body fat to excess, may cause serious negative health effects, including increased risk of heart disease, type 2 diabetes, stroke and certain cancers. The biology of obesity is complex and not well understood, involving both environmental and …
us
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Eric R. Reed, Jeanne C. Latourelle, Jeremy H. Bockholt, Joli Bregu et autres
OBJECTIVE: To investigate the feasibility of microRNA (miRNA) levels in CSF as biomarkers for prodromal Huntington disease (HD). METHODS: miRNA levels were measured in CSF from 60 PREDICT-HD study participants using the HTG protocol. Using a CAG-Age Product score, 30 prodromal HD …
us
(code pays fourni par la source)
Accès ouvert
2016
article
OpenAlex
Christian Wake, Adam Thomas Labadorf, Alexandra Dumitriu, Andrew G. Hoss et autres
BACKGROUND: MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression mainly through translational repression of target mRNA molecules. More than 2700 human miRNAs have been identified and some are known to be associated with disease phenotypes and to display tissue-specific patterns …
us
(code pays fourni par la source)
Accès ouvert
2016
erratum
OpenAlex
Adam Thomas Labadorf, Andrew G. Hoss, Valentina N. Lagomarsino, Jeanne C. Latourelle et autres
[This corrects the article DOI: 10.1371/journal.pone.0143563.].
Accès ouvert
2016
dataset
OpenAlex
Christian Wake, Adam Thomas Labadorf, Alexandra Dumitriu, Andrew G. Hoss et autres
Contains alignment information from good-quality mature sequence alignments of the 99 putative novel miRNAs to miRBase mature sequence entries. (XLSX 46Â kb)
Accès ouvert
2016
dataset
OpenAlex
Christian Wake, Adam Thomas Labadorf, Alexandra Dumitriu, Andrew G. Hoss et autres
Provides information on each of the 93 samples used in this study. This information includes ID, type (Control/HD/PD), PMI (Post-mortem-interval), age at death, sex, batch, brain bank, and cause of death. (XLSX 13Â kb)
Accès ouvert
2016
dataset
OpenAlex
Christian Wake, Adam Thomas Labadorf, Alexandra Dumitriu, Andrew G. Hoss et autres
A 99 Ă 93 table with raw read counts of the 99 putative novel miRNA results, for each of the 93 samples. (XLSX 45Â kb)
Accès ouvert
2016
dataset
OpenAlex
Christian Wake, Adam Thomas Labadorf, Alexandra Dumitriu, Andrew G. Hoss et autres
Contains summary information of each of the 99 novel putative miRNAs and the 30 miRNAs results from public data, in separate tabs. The following information is included in this file: mature and hairpin sequence loci, miRDeep* score, expression, the number of good-quality …
Accès ouvert
2016
dataset
OpenAlex
Christian Wake, Adam Thomas Labadorf, Alexandra Dumitriu, Andrew G. Hoss et autres
Contains alignment information from good-quality alignments of pairwise alignments of mature sequences of the 99 putative novel miRNAs. (XLSX 15Â kb)
Accès ouvert
2016
dataset
OpenAlex
Christian Wake, Adam Thomas Labadorf, Alexandra Dumitriu, Andrew G. Hoss et autres
A table containing information on the qRT-PCR performed with seven novel miRNAs and two known miRNAs. Per miRNA, this information includes mean CT, range of CT, cDNA dilution, the number of samples (of 12) with CTâ
Accès ouvert
2016
dataset
OpenAlex
Christian Wake, Adam Thomas Labadorf, Alexandra Dumitriu, Andrew G. Hoss et autres
Contains quality control information including the average read quality before and after quality and length filtering, the number of reads used in miRNA discovery and in differential expression analyses, and the number of reads removed for each length and quality filtering step. …
Accès ouvert
2015
article
OpenAlex
Adam Thomas Labadorf, Andrew G. Hoss, Valentina N. Lagomarsino, Jeanne C. Latourelle et autres
Huntington's Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has been documented but is incompletely understood. Here we present a genome-wide analysis …
us
(code pays fourni par la source)