Diana Li

2555-P: Double Knockout of INHBC and INHBE Protect against Diet-Induced Obesity and Insulin Resistance in Mice

Diana Li, Jason Mastaitis, SOO H. MIN, ERICH GOEBEL et autres

Introduction and Objective: ACVR1C and INHBE pLOFs and missense variants are associated with protection from type 2 diabetes. Ablation of Acvr1c or Inhbe in rodents drives body weight and fat loss, as well as fatty liver and insulin resistance, contradictory to the …

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Selective degradation of pathogenic autoantibodies by lysosomal targeting chimeras for the treatment of myasthenia gravis

Nicholas A. Lind, C. B. Collins, Craig Park, Rozhan Khaleghi et autres

Abstract Myasthenia gravis, an autoimmune disease characterized by muscle weakness that can manifest in bulbar dysfunction and respiratory distress, is driven in a subset of patients by autoantibodies against muscle-specific receptor tyrosine kinase (MuSK MG). MuSK MG and other autoantibody mediated disorders …

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Catalytic degradation of circulating targets with FcRn-mediated cycling LYTACs

Christos M. Kougentakis, Matthew J. Shurtleff, Rachel M. Lieser, Tao Chen et autres

Abstract Circulating proteins are common targets for the discovery of occupancy-based inhibitors including monoclonal antibodies. Effective inhibition of target pathogenicity with blocking approaches, however, is often challenged by target parameters that lead to insufficient occupancy and/or incomplete pharmacology limited by only single …

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The intestine is a major contributor to circulating succinate in mice

Wenxin Tong, Sarah Anissa Hannou, You Wang, Inna I. Astapova et autres

The tricarboxylic acid (TCA) cycle is the epicenter of cellular aerobic metabolism. TCA cycle intermediates facilitate energy production and provide anabolic precursors, but also function as intra- and extracellular metabolic signals regulating pleiotropic biological processes. Despite the importance of circulating TCA cycle …

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Glucagon-receptor-antagonism-mediated β-cell regeneration as an effective anti-diabetic therapy

Yannan Xi, Benbo Song, Iris Ngan, Mark J. Solloway et autres

Type 1 diabetes mellitus (T1D) is a chronic disease with potentially severe complications, and β-cell deficiency underlies this disease. Despite active research, no therapy to date has been able to induce β-cell regeneration in humans. Here, we discover the β-cell regenerative effects …

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“The Intestine is a Major Contributor to Circulating TCA Cycle Intermediates in Mice”

Wenxin Tong, Sarah Anissa Hannou, You Wang, Inna I. Astapova et autres

Abstract The tricarboxylic acid (TCA) cycle is the epicenter of cellular aerobic metabolism. TCA cycle intermediates facilitate energy production and provide anabolic precursors, but also function as intra- and extracellular metabolic signals regulating pleiotropic biological processes. Despite the importance of circulating TCA …

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The Intestine is a Major Contributor to Circulating TCA Cycle Intermediates in Mice

Mark A. Herman, Wenxin Tong, Sarah Anissa Hannou, You Wang et autres

The repository contains raw metabolomic data used for analyses related to the measurement of TCA cycle metabolite production from mouse intestine including the natural isotopomer abundance matrix used to normalize data in experiments using U-C13-Fructose gavage.

The Intestine is a Major Contributor to Circulating Succinate in Mice

Mark A. Herman, Wenxin Tong, Sarah Anissa Hannou, You Wang et autres

The repository contains raw metabolomic data used for analyses related to the measurement of TCA cycle metabolite production from mouse intestine including the natural isotopomer abundance matrix used to normalize data in experiments using U-C13-Fructose gavage.

Abstract 2579: Links between obesity and secreted frizzled-related protein 4 (Sfrp4) in a murine model of colon cancer

Elaine M. Glenny, Laura W. Bowers, Diana Li, Jatin Roper et autres

Abstract Obesity is a well-established risk factor for colon cancer and the effect of obesity-mediated inflammation is particularly pronounced in colon carcinogenesis. An incomplete understanding of the biology underlying this strong obesity-colon cancer association has hampered efforts to identify effective colon cancer …

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A phytic acid analogue INS‐3001 prevents ectopic calcification in an Abcc6−/− mouse model of pseudoxanthoma elasticum

Ida Joely Jacobs, Diana Li, Mattias E. Ivarsson, Jouni Uitto et autres

Abstract Pseudoxanthoma elasticum (PXE), a prototype of heritable ectopic calcification disorders, affects the skin, eyes and the cardiovascular system due to inactivating mutations in the ABCC6 gene. There is no effective treatment for the systemic manifestations of PXE. In this study, the …

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Glucagon Receptor Antagonism-Mediated β-Cell Regeneration as an Effective Anti-Diabetic Therapy

Yannan Xi, Benbo Song, Iris Ngan, Mark Humphrey et autres

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Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice

Rowena Suriben, Michael J. Chen, Jared Higbee, Julie Oeffinger et autres

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