Maike Wittersheim

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Figure S5 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Mladen Jokić, Ignacija Vlašić, Miriam Rinneburger, Niklas Klümper et autres

S5. (a-e) µCT-based monitoring of KPE and KPE post cis allograft tumor response in KPE syngeneic mice (n = 4) prior to and after etoposide treatment (Mice 2-5 shown). Allograft tumors are marked with "T".

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Figure S3 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Mladen Jokić, Ignacija Vlašić, Miriam Rinneburger, Niklas Klümper et autres

S3. Anti-Ercc1 immunostaining of lung sections of KPE mice (n = 8) after cisplatin treatment shown at different magnifications.

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Figure S4 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Mladen Jokić, Ignacija Vlašić, Miriam Rinneburger, Niklas Klümper et autres

S4. (a) Representative immunostaining of Pt-(GpG) adducts in KP and KPE cell lines after cisplatin exposure (left). Quantification of Pt-(GpG) adduct staining in KP (n = 5) and KPE (n = 6) cells after cisplatin exposure (right). P values were calculated using …

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Figure S1 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Mladen Jokić, Ignacija Vlašić, Miriam Rinneburger, Niklas Klümper et autres

S1.(a) Distribution of tumor vs. normal lung tissue in K, KE, KP and KPE mice at 4 weeks post tumor induction (top). Distribution of murine lung adenocarcinoma grades (G1, G2, G3) in corresponding K, KE, KP and KPE mice at 4 weeks …

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Figure S2 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Mladen Jokić, Ignacija Vlašić, Miriam Rinneburger, Niklas Klümper et autres

S2.(a) µCT-based monitoring of tumor response in K and KE mice prior to and after cisplatin treatment (left). Quantification of tumor volume in K and KE mice prior to and after cisplatin treatment (right). P values were calculated using two-tailed t-test. (b) …

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Figure S2 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Mladen Jokić, Ignacija Vlašić, Miriam Rinneburger, Niklas Klümper et autres

S2.(a) µCT-based monitoring of tumor response in K and KE mice prior to and after cisplatin treatment (left). Quantification of tumor volume in K and KE mice prior to and after cisplatin treatment (right). P values were calculated using two-tailed t-test. (b) …

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Figure S3 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Mladen Jokić, Ignacija Vlašić, Miriam Rinneburger, Niklas Klümper et autres

S3. Anti-Ercc1 immunostaining of lung sections of KPE mice (n = 8) after cisplatin treatment shown at different magnifications.

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Figure S1 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Mladen Jokić, Ignacija Vlašić, Miriam Rinneburger, Niklas Klümper et autres

S1.(a) Distribution of tumor vs. normal lung tissue in K, KE, KP and KPE mice at 4 weeks post tumor induction (top). Distribution of murine lung adenocarcinoma grades (G1, G2, G3) in corresponding K, KE, KP and KPE mice at 4 weeks …

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Figure S4 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Mladen Jokić, Ignacija Vlašić, Miriam Rinneburger, Niklas Klümper et autres

S4. (a) Representative immunostaining of Pt-(GpG) adducts in KP and KPE cell lines after cisplatin exposure (left). Quantification of Pt-(GpG) adduct staining in KP (n = 5) and KPE (n = 6) cells after cisplatin exposure (right). P values were calculated using …

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Figure S5 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Mladen Jokić, Ignacija Vlašić, Miriam Rinneburger, Niklas Klümper et autres

S5. (a-e) µCT-based monitoring of KPE and KPE post cis allograft tumor response in KPE syngeneic mice (n = 4) prior to and after etoposide treatment (Mice 2-5 shown). Allograft tumors are marked with "T".

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Data from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Mladen Jokić, Ignacija Vlašić, Miriam Rinneburger, Niklas Klümper et autres

Abstract KRAS-mutant lung adenocarcinoma is among the most common cancer entities and, in advanced stages, typically displays poor prognosis due to acquired resistance against chemotherapy, which is still largely based on cisplatin-containing combination regimens. Mechanisms of cisplatin resistance have been extensively investigated, …

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Data from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Mladen Jokić, Ignacija Vlašić, Miriam Rinneburger, Niklas Klümper et autres

Abstract KRAS-mutant lung adenocarcinoma is among the most common cancer entities and, in advanced stages, typically displays poor prognosis due to acquired resistance against chemotherapy, which is still largely based on cisplatin-containing combination regimens. Mechanisms of cisplatin resistance have been extensively investigated, …

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Maike Wittersheim

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Figure S5 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Figure S3 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Figure S4 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Figure S1 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Figure S2 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Figure S2 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Figure S3 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Figure S1 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Figure S4 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Figure S5 from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Data from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

Data from Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner

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