Mia Collins

Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma

Magnus Nilsson, Magdalena Rhedin, Ramon Hendrickx, Susanne Berglund et autres

Purpose: Janus kinase 1 (JAK1) is implicated in multiple inflammatory pathways that are critical for the pathogenesis of asthma, including the interleukin (IL)-4, IL-5, IL-13, and thymic stromal lymphopoietin cytokine signaling pathways, which have previously been targeted to treat allergic asthma. Here, …

se, gb, us (code pays fourni par la source)

AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2

Frank Narjes, Antonio Llinàs, Stefan von Berg, Johan Jirholt et autres

Inverse agonists of the nuclear receptor RORC2 have been widely pursued as a potential treatment for a variety of autoimmune diseases. We have discovered a novel series of isoindoline-based inverse agonists of the nuclear receptor RORC2, derived from our recently disclosed RORC2 …

se (code pays fourni par la source)

Beneficial effects of HDAC6 inhibition on airway epithelial barrier function

Mia Collins, Jenny Horndahl, Rebecka Svärd, Theresa Andreasson et autres

Chronic obstructive pulmonary disease (COPD) is a heterogeneous respiratory condition characterized by airway inflammation, remodeling and restricted pulmonary air flow. Novel therapies are required to treat underlying causes, such as cigarette smoke (CSE)-induced epithelium stress and destruction, as well as breakdown of …

se (code pays fourni par la source)

Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2

Stefan von Berg, Yafeng Xue, Mia Collins, Antonio Llinàs et autres

The further optimization of a recently disclosed series of inverse agonists of the nuclear receptor RORC2 is described. Investigations into the left-hand side of compound 1, guided by X-ray crystal structures, led to the substitution of the 4-aryl-thiophenyl residue with the hexafluoro-2-phenyl-propan-2-ol …

se, au (code pays fourni par la source)

Central role for phosphoinositide-3-kinase gamma/delta dependent signalling in eosinophilic pulmonary inflammation driven by innate lymphoid cells

Matt Thomas, Karin Björhall, Mia Collins, Elisabeth Israelsson et autres

Severe eosinophilic asthma remains a clinical burden, potentially due to the multiple mechanisms by which type 2 inflammation can arise. Here we show how epithelial alarmin stimulation of innate lymphoid type 2 cells (ILC2s) can promote Th2 cell activity and subsequent eosinophil …

gb, ch (code pays fourni par la source)

MICHIGAN CREDIT UNION LEAGUE (MCUL) CU DIFFERENCE COMMITTEE

Mcul Lansing, Livonia Office, Heather Bade, Danielle Brehmer et autres