Jonathan Boyd

Fentanyl-induced cortical and cardiopulmonary damage linked to immune response functions and apoptosis-necrosis networks in a multi-omics mouse model

Nabarun Chakraborty, Mital Y. Patel, Swapna Kannan, Candace Moyler et autres

Introduction: imaging with multi-omics data, enabling a comprehensive understanding of tissue-specific host responses across time and dose gradients. Methods: Our previous study characterized the phenotypes of this mouse model to establish dose gradients and time points associated with major clinical manifestations. Building …

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Pregnancy and Postpartum Effects of Electronic Cigarettes on Maternal Health and Vascular Function in the Fourth Trimester

Amber Mills, Duaa Dakhlallah, Anand Ranpara, William T. Goldsmith et autres

Pregnancy is a vulnerable time with significant cardiovascular changes that can lead to adverse outcomes, which can extend into the postpartum window. Exposure to emissions from electronic cigarettes (Ecig), commonly known as "vaping," has an adverse impact on cardiovascular function during pregnancy …

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Adoptive transfer of immunomodulatory macrophages reduces the pro-inflammatory microenvironment and increases bone formation on titanium implants

Lais Morandini, Tyler J. Heath, Luke Sheakley, Derek Avery et autres

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Fentanyl Overdose Causes Prolonged Cardiopulmonary Dysregulation in Male SKH1 Mice

Mackenzie Newman, Heather Connery, Swapna Kannan, Aarti Gautam et autres

Fentanyl overdose is a survivable condition that commonly resolves without chronic overt changes in phenotype. While the acute physiological effects of fentanyl overdose, such as opioid-induced respiratory depression (OIRD) and Wooden Chest Syndrome, represent immediate risks of lethality, little is known about …

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Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice

Mackenzie Newman, Cayla Lynch, Heather Connery, William T. Goldsmith et autres

Abstract Fentanyl exposure and overdose are growing concerns in public health and occupational safety. This study aimed to establish parameters of fentanyl lethality in SKH1 mice for future overdose research. Lethality was determined using the up‐down procedure, with subjects monitored post‐administration using …

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Mapping Signaling Mechanisms in Neurotoxic Injury from Sparsely Sampled Data Using a Constraint Satisfaction Framework

J. Page, Kimberly A. Kelly, Lindsay T. Michalovicz, James P. O’Callahghan et autres

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Developing an Image Based Deep Learning Approach to Immune Cell Quantification in a Mouse Asthma Model

Jonathan Boyd, Nathalie Fuentes, Christine Tkaczyk

House dust mites (HDM) are associated with asthma severity and progression [1], and scientists have adapted HDM to model asthma phenotypes in mice. To understand how the immune system responds to the allergen, we wanted to develop an imaging and machine learning …

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Maternal Vaping during Pregnancy E-cigs Leads to Obesity in Offspring

Amber Mills, Sydney Nassabeh, James Frazier, Madison Robinson et autres

Electronic cigarettes (E-cigs) have been strategically marketed as a safer alternative to smoking even during pregnancy. Previous literature suggests that direct exposure to E-cigs disrupts insulin sensitivity and mitochondrial function. Yet, there are few studies looking into maternal E-cig exposure and the …

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Machine Learning Techniques to Predict Voltage Unbalance in a Power Transmission System

Jonathan Boyd, Donald R. Reising, Anthony B. Murphy, Justin Kuhlers et autres

Voltage unbalance is a growing issue that, among other things, can impact three-phase motor and drive loads, result in nuisance tripping of generation units and capacitor banks, and prevent optimization of conservative voltage regulation strategies. This difference between the three phases of …

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Machine Learning Techniques to Predict Voltage Unbalance in a Power Transmission System

Jonathan Boyd, Donald R. Reising, Anthony B. Murphy, Justin Kuhlers et autres

Voltage unbalance is a growing issue that, among other things, can impact three-phase motor and drive loads, result in nuisance tripping of generation units and capacitor banks, and prevent optimization of conservative voltage regulation strategies. This difference between the three phases of …

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Eco-Friendly Hierarchical Nanoporous Microfiber Respirator Filters Fabricated Using Rotary Jet Spinning Technology (RJS)

Kavin Sivaneri Varadharajan Idhaiam, Gloria S. Oporto, Matthew Barre, Masako Terada et autres

The current global health crisis caused by the SARS-CoV-2 virus (COVID-19) has increased the use of personal protective equipment, especially face masks, leading to the disposal of a large amount of plastic waste causing an environmental crisis due to the use of …

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Opioids and Vitamin C: Known Interactions and Potential for Redox-Signaling Crosstalk

Mackenzie Newman, Heather Connery, Jonathan Boyd

Opioids are among the most widely used classes of pharmacologically active compounds both clinically and recreationally. Beyond their analgesic efficacy via μ opioid receptor (MOR) agonism, a prominent side effect is central respiratory depression, leading to systemic hypoxia and free radical generation. …

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