Josette Perrier

The broad-spectrum RumC1 bacteriocin targets a transient peptidoglycan intermediate of the nascent cell wall

Anne Boyeldieu, Mathieu Bergé, Clarisse Roblin, LAMA SHAMSEDDINE et autres

RumC1 is a structurally unique bacteriocin with broad-spectrum efficacy, including against multidrug-resistant pathogens, yet acting by an undefined mechanism. By integrating genetics, biochemistry, computational modeling and single-cell fluorescence microscopy, we demonstrate that RumC1 is a distinct cell-wall-targeting toxin. First, all RumC1-resistant mutants …

us, fr, es (code pays fourni par la source)

Impact of Regulated and Non-Regulated Food-Associated Mycotoxins on the Viability and Proliferation of Enteric Glial Cells

Michał Dąbrowski, Hamza Olleik, Attilio Di Maio, Amine Kadri et autres

(1) Background: Humans and animals are exposed daily to numerous food-associated noxious molecules, including fungal toxins or mycotoxins. Effects of mycotoxins on the intestinal epithelial cells (IECs) are well characterized. However, their impact on the enteric nervous system (ENS), particularly on enteric …

pl, fr, nl (code pays fourni par la source)

Design and Synthesis of Novel Amino and Acetamidoaurones with Antimicrobial Activities

Attilio Di Maio, Hamza Olleik, Elise Courvoisier‐Dezord, Sophie Guillier et autres

The development of new and effective antimicrobial compounds is urgent due to the emergence of resistant bacteria. Natural plant flavonoids are known to be effective molecules, but their activity and selectivity have to be increased. Based on previous aurone potency, we designed …

fr, lb (code pays fourni par la source)

Design and Synthesis of Novel Amino and Acetamidoaurones with Antimicrobial Activities

Attilio Di Maio, Hamza Olleik, Elise Courvoisier‐Dezord, Sophie Guillier et autres

The development of new and effective antimicrobial compounds is an urgent need with the emergence of resistant bacteria. Natural plant flavonoids are known to be effective molecules but their activity and selectivity have to be increased. Based on previous aurone potency, we …

fr, lb (code pays fourni par la source)

Mechanistic and functional aspects of the Ruminococcin C sactipeptide isoforms

Lama Shamseddine, Clarisse Roblin, Iris Veyrier, Christian Basset et autres

In a scenario where the discovery of new molecules to fight antibiotic resistance is a public health concern, ribosomally synthesized and post-translationally modified peptides constitute a promising alternative. In this context, the Gram-positive human gut symbiont Ruminococcus gnavus E1 produces five sactipeptides, …

fr (code pays fourni par la source)

Correction for Roblin et al., The unusual structure of Ruminococcin C1 antimicrobial peptide confers clinical properties

Clarisse Roblin, Steve Chiumento, Olivier Bornet, Matthieu Nouailler et autres

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.

fr, de (code pays fourni par la source)

Evaluation of the Efficiency of Random and Diblock Methacrylate-Based Amphiphilic Cationic Polymers against Major Bacterial Pathogens Associated with Cystic Fibrosis

Magali Casanova, Hamza Olleik, Slim Hdiouech, Clarisse Roblin et autres

Cystic fibrosis (CF) is associated with repeated lung bacterial infection, mainly by Pseudomonas aeruginosa, Staphylococcus aureus, and Mycobacterium abscessus, all known to be or becoming resistant to several antibiotics, often leading to therapeutic failure and death. In this context, antimicrobial peptides and …

fr (code pays fourni par la source)

Antimicrobial Peptides and Peptidomimetics as Treatment Option for Helicobacter pylori Infection

Hamza Olleik, Josette Perrier, Akram Hijazi, Elias Baydoun et autres

fr, lb (code pays fourni par la source)

Antimicrobial Ribosomally Synthesized and Post-Translationally Modified Peptides as a Source of Alternatives to Antibiotics: A Focus on the Sactipeptides and Ranthipeptides Subclasses

Clarisse Roblin, Pierre Rousselot‐Pailley, Victor Duarte, Josette Perrier et autres

fr (code pays fourni par la source)

In silico identification of two peptides with antibacterial activity against multidrug-resistant Staphylococcus aureus

Linda Oyama, Hamza Olleik, Ana Carolina Nery Teixeira, Matheus M Guidini et autres

Here we report two antimicrobial peptides (AMPs), HG2 and HG4 identified from a rumen microbiome metagenomic dataset, with activity against multidrug-resistant (MDR) bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA) strains, a major hospital and community-acquired pathogen. We employed the classifier model design to …

gb, fr, br, de, us (code pays fourni par la source)

RadA, a MSCRAMM Adhesin of the Dominant Symbiote Ruminococcus gnavus E1, Binds Human Immunoglobulins and Intestinal Mucins

Marc Maresca, Radia Alatou, Ange Pujol, Cendrine Nicoletti et autres

Adhesion to the digestive mucosa is considered a key factor for bacterial persistence within the gut. In this study, we show that Ruminococcus gnavus E1 can express the radA gene, which encodes an adhesin of the MSCRAMMs family, only when it colonizes …

fr, Algérie (code pays fourni par la source)

The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health

Clarisse Roblin, Steve Chiumento, Cédric Jacqueline, Eric Pinloche et autres

The world is on the verge of a major antibiotic crisis as the emergence of resistant bacteria is increasing, and very few novel molecules have been discovered since the 1960s. In this context, scientists have been exploring alternatives to conventional antibiotics, such …

fr (code pays fourni par la source)