John P. Woodhouse

Diagnostic BMI and Induction Therapy Weight Change Associated With Hepatotoxicity in Pediatric Patients With Acute Lymphoblastic Leukemia

Emily J. Mason, John P. Woodhouse, Jeremy M. Schraw, Joanna S. Yi et autres

BACKGROUND: Hepatotoxicity is a common treatment-related complication in pediatric acute lymphoblastic leukemia (ALL). Excess adiposity at diagnosis has been identified as a risk factor, but the impact of weight change during therapy has not been examined. METHODS: We included patients aged 2-20 …

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Institution-Specific LLM Prompting Recovers PHI That De-identification Systems and Their Gold Standards Both Miss

Daniel Palacios, Matthew Brady Neeley, Angel Adetomike Otto, Shalini Dhamodharan et autres

Secondary use of electronic health records requires de-identification, yet existing systems miss \emph{institutionally situated} protected health information (PHI) such as hospital abbreviations, building names, and internal codes whose status is locally determined. We ask whether large language models (LLMs) with in-context learning …

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges et autres

ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and …

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Lipidomic profiles associated with treatment related hepatotoxicity in children with acute lymphoblastic leukemia

Emily J. Mason, Jeremy M. Schraw, John P. Woodhouse, M. Monica Gramatges et autres

INTRODUCTION: Treatment for childhood acute lymphoblastic leukemia (ALL) can result in hepatotoxicity. Despite being a common complication of ALL therapy, mechanisms and biomarkers of treatment-associated hepatotoxicity (TAH) are not well described. METHODS: We conducted lipidomic profiling to identify plasma lipids associated with …

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Incidence and outcomes of treatment-associated hepatotoxicity during pediatric acute lymphoblastic leukemia induction therapy: a Reducing Ethnic Disparities in Acute Leukemia (REDIAL) Consortium report

Ashley Chavana, Emily J. Mason, John P. Woodhouse, Olga A. Taylor et autres

Not available.

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An analysis of diagnostic metabolomic profiles associated with hepatotoxicity during childhood ALL induction therapy

Emily J. Mason, A. Lauren Crain, Michael E. Scheurer, Philip J. Lupo et autres

ABSTRACT: Hepatotoxicity is a well-documented complication of induction chemotherapy for acute lymphoblastic leukemia (ALL), but our understanding of its biological mechanisms is limited. We identified 314 patients with ALL (aged 1-19 years) treated at Texas Children's Hospital (2008-2019) with diagnostic bone marrow …

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Developmental Trajectories of Adaptive Functioning and Behavior Problems in Children With Co-Occurring Tuberous Sclerosis Complex and Autism Spectrum Disorder, With and Without Seizures

Lynnel C. Goodman, Melissa A. Richard, John P. Woodhouse, S. Katie Z. Ihnen et autres

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Epigenomic signature of major congenital heart defects in newborns with Down syndrome

Julia S. Mouat, Shaobo Li, Swe Swe Myint, Benjamin I. Laufer et autres

BACKGROUND: Congenital heart defects (CHDs) affect approximately half of individuals with Down syndrome (DS), but the molecular reasons for incomplete penetrance are unknown. Previous studies have largely focused on identifying genetic risk factors associated with CHDs in individuals with DS, but comprehensive …

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Epigenomic signature of major congenital heart defects in newborns with Down syndrome

Julia S. Mouat, Shaobo Li, Swe Swe Myint, Benjamin I. Laufer et autres

ABSTRACT Background Congenital heart defects (CHDs) affect approximately half of individuals with Down syndrome (DS) but the molecular reasons for incomplete penetrance are unknown. Previous studies have largely focused on identifying genetic risk factors associated with CHDs in individuals with DS, but …

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Additional file 1 of Epigenomic signature of major congenital heart defects in newborns with Down syndrome

Julia S. Mouat, Shaobo Li, Swe Swe Myint, Benjamin I. Laufer et autres

Additional file 1: Table S1. Study characteristics: description of sample traits included in study. Table S2. Sample traits: values of traits for each sample. Table S3. Welch’s t test for differences in sample traits in DS-CHD versus DS non-CHD samples. Table S4. …

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Factors associated with nonsyndromic anotia and microtia, Texas, 1999–2014

Jeremy M. Schraw, John P. Woodhouse, Renata H. Benjamin, Charles Shumate et autres

BACKGROUND: Few risk factors have been identified for nonsyndromic anotia/microtia (A/M). METHODS: We obtained data on cases and a reference population of all livebirths in Texas for 1999-2014 from the Texas Birth Defects Registry (TBDR) and Texas vital records. We estimated prevalence …

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Abstract 3671: Association between residence in a Hispanic enclave and end-induction minimal residual disease among children with acute lymphoblastic leukemia in Texas

Joshua P. Muñiz, John P. Woodhouse, Amy E. Hughes, Sandi L. Pruitt et autres

Abstract Background: Acute lymphoblastic leukemia (ALL) remains a leading cause of death in children and adolescents. We have demonstrated that Hispanic enclaves - neighborhoods with high proportions of Spanish-speaking residents, recent immigrants, and ethnic-specific businesses - are associated with inferior overall survival …

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