Lingxiong Wang

Prediction of pulmonary infection during chemotherapy in non-small cell lung cancer: development and internal validation of a nomogram

Jianqing Hao, Jinfeng Li, Nana Lv, Huhu Chen et autres

Objective: To develop and internally validate a nomogram for predicting pulmonary infection during chemotherapy in patients with non-small cell lung cancer (NSCLC). Methods: This retrospective study included 246 NSCLC patients receiving cytotoxic chemotherapy. The primary outcome was pulmonary infection during chemotherapy. Patients …

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ANP32A negatively regulates PD-L1 expression by acting as the inhibitor of histone acetylase in non-small cell lung cancer

Jinfeng Li, Jianqing Hao, Di Huang, Di Lu et autres

In recent years, immunotherapies with checkpoint inhibitor programmed death ligand 1 (PD-L1)/programmed cell death 1 (PD-1) antibodies have offered a promising new approach to advanced non-small cell lung cancer (NSCLC). Although many NSCLC patients have shown a long-term and lasting response, the …

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Spatial distribution analysis of tertiary lymphoid structures in esophageal squamous cell carcinoma predicts patient survival and response to neoadjuvant chemo-immunotherapy

Lingxiong Wang, Jinfeng Li, Yanyun Ao, Yanju Yu et autres

BACKGROUND: The prognostic and predictive significance of tertiary lymphoid structures (TLSs) exhibits spatial specificity in various cancers. However, the spatial distribution, phenotypic characteristics of TLSs in esophageal squamous cell carcinoma (ESCC) and their impact on prognosis and prediction are not yet fully …

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Anemia Impairs Non-small Cell Lung Cancer Immunotherapy Efficacy through CD8+ T Cell Dysfunction

Yaping Long, Xuan Han, Yao Li, Xiao Han et autres

Recruited Monocyte-Derived Macrophages Drive T Cell Inflammation in Immune Checkpoint Inhibitor-Mediated Pneumonitis

Xiaoran Cui, Renyong Zhi, Xiaoyan Li, Yinming Ji et autres

Background: Immune checkpoint inhibitor-mediated pneumonitis (CIP) constitutes a major toxicity that limits the clinical application of cancer immunotherapy, whereas its underlying mechanisms remain incompletely understood. Current management relies on nonspecific immunosuppressants, lacking precision therapies. Although single-cell RNA sequencing (scRNA-seq) of bronchoalveolar lavage …

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Spatial distribution analysis of tertiary lymphoid structures in esophageal squamous cell carcinoma predicts patient survival and response to neoadjuvant chemo-immunotherapy

Lingxiong Wang, Jinfeng Li, Yanyun Ao, Yanju Yu et autres

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Identification of a prognostic signature consisting of three macrophage-related genes for glioblastoma based on bulk and single-cell transcriptomes analyses

Qiyan Wu, Chuanbiao Chen, Lina Li, Hongyu Liu et autres

BACKGROUND: Tumor-associated macrophages have been implicated in the progression and treatment resistance of glioblastoma (GBM). This study aimed to identify macrophage-related genes associated with prognosis and therapeutic response in GBM. MATERIALS AND METHODS: Bulk RNA-seq data from 533 patients with GBM were …

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Integrated analyses reveal IDO1 as a prognostic biomarker coexpressed with PD-1 on tumor-associated macrophages in esophageal squamous cell carcinoma

Yaojun Peng, Lingxiong Wang, Juan Yang, Qiyan Wu et autres

Background: Inhibition of indolamine-2,3-dioxygenase 1 (IDO1) has been proposed as a promising strategy for cancer immunotherapy; however, it has failed in clinical trials. Macrophages in the tumor microenvironment (TME) contribute to immune escape and serve as potential therapeutic targets. This study investigated …

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Tumor-derived DEFB1 induces immune tolerance by inhibiting maturation of dendritic cell and impairing CD8+ T cell function in esophageal squamous cell carcinoma

Jingjing Duan, Haotian Wang, Minglu Liu, Yin Chen et autres

ObjectiveCD8+ T cells are the key effector cells in the anti-tumor immune response. The mechanism underlying the infiltration of CD8+ T cells in esophageal squamous cell carcinoma (ESCC) has not been clearly elucidated. MethodsFresh ESCC tissues were collected and grouped according to …

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The level of macrophage migration inhibitory factor is negatively correlated with the efficacy of PD-1 blockade immunotherapy combined with chemotherapy as a neoadjuvant therapy for esophageal squamous cell carcinoma

Liangliang Wu, Yiming Gao, Shengzhi Xie, Ye Wan et autres

PURPOSE: This study aimed to screen biomarkers to predict the efficacy of programmed cell death 1 (PD-1) blockade immunotherapy combined with chemotherapy as neoadjuvant therapy for esophageal squamous cell carcinoma (ESCC). METHODS: In the first stage of the study, the baseline concentrations …

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A hypoxia- and lactate metabolism-related gene signature to predict prognosis of sepsis: discovery and validation in independent cohorts

Yaojun Peng, Qiyan Wu, Xinhuan Ding, Lingxiong Wang et autres

BACKGROUND: High throughput gene expression profiling is a valuable tool in providing insight into the molecular mechanism of human diseases. Hypoxia- and lactate metabolism-related genes (HLMRGs) are fundamentally dysregulated in sepsis and have great predictive potential. Therefore, we attempted to build an …

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Integrated bioinformatics analysis and experimental validation reveal ISG20 as a novel prognostic indicator expressed on M2 macrophage in glioma

Yaojun Peng, Hongyu Liu, Qiyan Wu, Lingxiong Wang et autres

BACKGROUND: Glioma is the most common malignant primary brain tumor and is characterized by a poor prognosis and limited therapeutic options. ISG20 expression is induced by interferons or double-stranded RNA and is associated with poor prognosis in several malignant tumors. Nevertheless, the …

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