Accès ouvert
2024
article
OpenAlex
Katherine L. Williams, Steve Guerrero, Yevel Flores-García, Dongkyoon Kim et autres
Over 75% of malaria-attributable deaths occur in children under the age of 5 years. However, the first malaria vaccine recommended by the World Health Organization (WHO) for pediatric use, RTS,S/AS01 (Mosquirix), has modest efficacy. Complementary strategies, including monoclonal antibodies, will be important …
us, be
(code pays fourni par la source)
Accès ouvert
2023
dataset
OpenAlex
Katherine L. Williams, Anthony Guerrero, Yevel Flores-García, Dongkyoon Kim et autres
Plasmablast human antibody repertoire sequences from volunteers in a malaria vaccine (RTS,S) clinical trial with sequence and donor annotations
Accès ouvert
2023
dataset
OpenAlex
Katherine L. Williams, Anthony Guerrero, Yevel Flores-García, Dongkyoon Kim et autres
Plasmablast human antibody repertoire sequences from volunteers in a malaria vaccine (RTS,S) clinical trial with sequence and donor annotations
Accès ouvert
2023
preprint
OpenAlex
Katherine L. Williams, Steve Guerrero, Yevel Flores-García, Kayla Andrews et autres
Abstract Over 80% of malaria-attributable deaths are in children under five. However, the only malaria vaccine recommended by the World Health Organization (WHO) for paediatric use, Mosquirix™, has limited efficacy. Complementary strategies, like monoclonal antibodies (mAbs), will be required to eradicate malaria. …
us, de, be, mm
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
A. Scholz, Jeff DeFalco, Yvonne Leung, Iraz T. Aydin et autres
Immunotherapy approaches focusing on T cells have provided breakthroughs in treating solid tumors. However, there remains an opportunity to drive anticancer immune responses via other cell types, particularly myeloid cells. ATRC-101 was identified via a target-agnostic process evaluating antibodies produced by the …
us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Lindsay C. Dahora, Marije K. Verheul, Katherine L. Williams, Celina Jin et autres
Typhi Vi and enriching for antibody Fc functions that protect against typhoid fever will advance the design of high-efficacy Vi vaccines for protection across diverse populations.
us, gb, py
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Deniz Cizmeci, Giuseppe Lofano, Evan Rossignol, Anne‐Sophie Dugast et autres
A minor subset of individuals infected with HIV-1 develop antibody neutralization breadth during the natural course of the infection, often linked to chronic, high-level viremia. Despite significant efforts, vaccination strategies have been unable to induce similar neutralization breadth and the mechanisms underlying …
us
(code pays fourni par la source)
Accès ouvert
2021
peer-review
OpenAlex
Deniz Cizmeci, Giuseppe Lofano, Evan Rossignol, Anne‐Sophie Dugast et autres
us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Christian Schmidt, Laura Christian, Tyler A. Smith, Josephine Tidwell et autres
Several diseases originate via dysregulation of the actin cytoskeleton. The ARID3A/Bright transcription factor has also been implicated in malignancies, primarily those derived from hematopoietic lineages. Previously, we demonstrated that ARID3A shuttles between the nucleus and the plasma membrane, where it localizes within …
de, us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
David Forgacs, Rodrigo B. Abreu, Giuseppe A. Sautto, Greg A. Kirchenbaum et autres
Recent advances in high-throughput single cell sequencing have opened up new avenues into the investigation of B cell receptor (BCR) repertoires. In this study, PBMCs were collected from 17 human participants vaccinated with the split-inactivated influenza virus vaccine during the 2016-2017 influenza …
us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Christian Schmidt, Laura Christian, Josephine Tidwell, Dongkyoon Kim et autres
ABSTRACT Previously we demonstrated that the ARID3A transcription factor shuttles between the nucleus and the plasma membrane, where it localizes within lipid rafts. There it interacts with components of the B Cell Receptor (BCR) to reduce its ability to transmit downstream signaling. …
de, us
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Deniz Cizmeci, Giuseppe Lofano, Anne‐Sophie Dugast, Dongkyoon Kim et autres
Abstract A minor subset of individuals infected with HIV-1 develop antibody neutralization breadth during the natural course of the infection, often linked to chronic, high level viremia. Despite significant efforts, vaccination strategies have been unable to induce similar neutralization breadth and the …
us
(code pays fourni par la source)