Helga Moncayo

Identifying Hypoxia and Glycolysis in Chemotherapy- and Radiation-Induced Cardiotoxicity by Nuclear Medicine Diagnostic Imaging With 18F-Flurodeoxyglucose – Key Role of Coenzyme Q10 Deficiency in Acquired Mitochondrial Dysfunction

Roy Moncayo, Helga Moncayo

Cardiotoxicity is an unwanted side-effect arising from different medications. The term describes a diminution of heart function, affecting especially left ventricular ejection fraction, which can progress to heart failure. Pediatric oncology patients treated with drugs of the anthracycline group, e.g., doxorubicin, can …

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From the Thyroid to the Heart

Roy Moncayo, Helga Moncayo

The pathogenesis of human disease is commonly considered to be unique to each organ or system. This has led to specialization in medical practice leaving little space for global pathogenesis concepts. In this review we have departed from a biochemical concept of …

Practical Guidelines for Diagnosing and Treating Thyroid Disease Based on the WOMED Metabolic Model of Disease Focusing on Glycolysis and Coenzyme Q10 Deficiency—A Clinical Alternative to the 2021 Retired Clinical Practice Guidelines of the Endocrine Society

Roy Moncayo, Helga Moncayo

This review aims to provide a functional, metabolic view of the pathogenesis of benign thyroid disease. Here, we summarize the features of our previous publications on the “WOMED model of benign thyroid disease”. As of 2021, the current state of art indicates …

Translating Results from The Womed Model of Benign Thyroid Disease to A Practical Approach to Treat Fatigue In COVID-19 Patients Based on Combined Supplementation with Magnesium, Selenium, and Coenzyme Q10: A Treatment Strategy against Fatigue

Moncayo Roy, Helga Moncayo

We describe a small series of patients who were examined at a time post-COVID-19 infection.The main common complaint at presentation was fatigue.Using a previously described and clinically validated examination method based on 3D-Power Doppler sonography of the thyroid, we could identify signs …

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Understanding the pathogenesis of peripartum heart failure in northern Nigeria based on interactions of external heat stress conditions with coenzyme Q10, selenium and magnesium - shared biochemical similarities with the pathogenesis of thyroid disease

Roy Moncayo, Helga Moncayo

A recent publication in the Canadian Journal of Cardiology has described a case of post-partum heart failure with concomitant hyperthyroidism due to thyroiditis.In an accompanying Editorial a potential multisystemic nature of both entities was proposed.The hypothesis motivated us to review the relevant …

Repairing the damaged thyroid proteome through tailored supplementation with magnesium, selenium and coenzyme Q10: potential applicability for cardiac disease

Roy Moncayo, Helga Moncayo, J Reisenzahn

The concept of a proteostasis network has been proposed as a general mechanism for maintaining cellular function and integrity.The network includes a series of biochemical elements, which require energy in the form of ATP.This aspect, however, has received little attention in scientific …

Applying a systems approach to thyroid physiology: Looking at the whole with a mitochondrial perspective instead of judging single TSH values or why we should know more about mitochondria to understand metabolism

Roy Moncayo, Helga Moncayo

Classical thinking in endocrine physiology squeezes our diagnostic handling into a simple negative feedback mechanism with a controller and a controlled variable. In the case of the thyroid this is reduced to TSH and fT3 and fT4, respectively. The setting of this …

A post-publication analysis of the idealized upper reference value of 2.5 mIU/L for TSH: Time to support the thyroid axis with magnesium and iron especially in the setting of reproduction medicine

Roy Moncayo, Helga Moncayo

Laboratory medicine approaches the evaluation of thyroid function mostly through the single determination of the blood level of thyroid stimulating hormone (TSH). Some authors have suggested an upper reference value for TSH of 2.5 mIU/L. This suggestion has not been confirmed by …

The role of magnesium and thyroid function in early pregnancy after in-vitro fertilization (IVF): New aspects in endocrine physiology

Sibilla Stuefer, Helga Moncayo, Roy Moncayo

BACKGROUND: The initiation of a pregnancy is a process that requires adequate energetic support. Recent observations at our Institution suggest a central role of magnesium in this situation. The aim of this study was to evaluate magnesium, zinc, selenium and thyroid function …

Thyroid function parameters in normal pregnancies in an iodine sufficient population

Roy Moncayo, Birgit Zanon, K. Heim, Karina Ortner et autres

BACKGROUND: The aim of this retrospective observational study was to describe thyroid function parameters (fT3, fT4 and TSH) in the course of normal pregnancies. METHODS: Data were obtained between 2006 and 2007 at the University Hospital in Innsbruck, Austria. The starting point …

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Proof of concept of the WOMED model of benign thyroid disease: Restitution of thyroid morphology after correction of physical and psychological stressors and magnesium supplementation

Roy Moncayo, Helga Moncayo

BACKGROUND: The aim of this study was to investigate the influence of a combined supplementation with magnesium, selenium and coenzyme Q10 on the morphology of the thyroid in patients with benign diseases. The clinical examination and treatment approach aims additionally at treating …

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The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation

Roy Moncayo, Helga Moncayo

BACKGROUND: The aim of this study was to discern whether a relation between biochemical parameters, sonography and musculoskeletal data exists in cases of hyperthyroidism and whether they are modifiable through supplementation with selenomethionine and magnesium citrate as well as by acupuncture and …