Michele S. Y. Tan

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor

Michele S. Y. Tan, Konstantinos Koussis, Chrislaine Withers‐Martinez, Steven A. Howell et autres

Malaria parasite egress from host erythrocytes (RBCs) is regulated by discharge of a parasite serine protease called SUB1 into the parasitophorous vacuole (PV). There, SUB1 activates a PV-resident cysteine protease called SERA6, enabling host RBC rupture through SERA6-mediated degradation of the RBC …

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Malaria parasite egress at a glance

Michele S. Y. Tan, Michael J. Blackman

ABSTRACT All intracellular pathogens must escape (egress) from the confines of their host cell to disseminate and proliferate. The malaria parasite only replicates in an intracellular vacuole or in a cyst, and must undergo egress at four distinct phases during its complex …

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Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy

Simona Balestrini, Matthias J. Koepp, Sonia Gandhi, Hannah M. Rickman et autres

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Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken, Karen V. Ambrose, Sam Barrell, Rupert C. L. Beale et autres

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Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken, Karen V. Ambrose, Sam Barrell, Rupert C. L. Beale et autres

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Correction: Novel broad-spectrum activity-based probes to profile malarial cysteine proteases

Michele S. Y. Tan, Dara Davison, Mateo I. Sánchez, Bethany M. Anderson et autres

[This corrects the article DOI: 10.1371/journal.pone.0227341.].

Novel broad-spectrum activity-based probes to profile malarial cysteine proteases

Michele S. Y. Tan, Dara Davison, Mateo I. Sánchez, Bethany M. Anderson et autres

Clan CA cysteine proteases, also known as papain-like proteases, play important roles throughout the malaria parasite life cycle and are therefore potential drug targets to treat this disease and prevent its transmission. In order to study the biological function of these proteases …

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Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite

Christine Lehmann, Michele S. Y. Tan, Laura E. de Vries, Ilaria Russo et autres

Parasite egress from infected erythrocytes and invasion of new red blood cells are essential processes for the exponential asexual replication of the malaria parasite. These two tightly coordinated events take place in less than a minute and are in part regulated and …

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Publisher Correction: A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells

J. Alero Thomas, Michele S. Y. Tan, Claudine Bisson, Aaron J. Borg et autres

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A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells

J. Alero Thomas, Michele S. Y. Tan, Claudine Bisson, Aaron J. Borg et autres

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Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite

Christine Lehmann, Michele S. Y. Tan, Laura E. de Vries, Ilaria Russo et autres

ABSTRACT Parasite egress from infected erythrocytes and invasion of new erythrocytes are essential for the exponential asexual replication of the malaria parasite, and both processes are regulated and mediated by proteases. The putative cysteine protease dipeptidyl aminopeptidase 3 (DPAP3) was previously suggested …

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The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes

Christine R. Collins, Fiona Hackett, Jonathan Atid, Michele S. Y. Tan et autres

Egress of the malaria parasite Plasmodium falciparum from its host red blood cell is a rapid, highly regulated event that is essential for maintenance and completion of the parasite life cycle.Egress is protease-dependent and is temporally associated with extensive proteolytic modification of …

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