Sarah Drake

Rapid Access Diagnostics for Asthma (RADicA): protocol for a prospective cohort study to determine the optimum series of investigations to diagnose asthma using conventional and novel tests

Clare Murray, Stephen J. Fowler, Sarah Drake, Ran Wang et autres

INTRODUCTION: The diagnosis of asthma is often based on characteristic patterns of symptoms in the absence of an alternative explanation, resulting in over and under diagnosis. Therefore, diagnostic guidelines usually recommend including confirmation of variable airflow obstruction. Some recommend using a sequence …

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Concordance between ERS, GINA and NICE guidelines for the diagnosis of asthma in adults

Andrew Simpson, Ran Wang, Sarah Drake, Laura Healy et autres

Introduction: Significant heterogeneity exists in the approach to diagnosing asthma across guidelines. Aim: Evaluate the concordance between the European Respiratory Society (ERS), the National Institute for Health and Care Excellence (NICE) and the Global Initiative for Asthma (GINA) guidelines for diagnosing asthma …

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Asthma diagnosis: a comparison of established diagnostic guidelines in adults with respiratory symptoms

Andrew Simpson, Sarah Drake, Laura Healy, Ran Wang et autres

Background: Considerable variability exists between asthma diagnostic guidelines. We tested the performance characteristics of the European Respiratory Society (ERS), the National Institute for Health and Care Excellence (NICE) and the Global Initiative for Asthma (GINA) guidelines for the diagnosis of asthma in …

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Asthma Diagnosis: A Comparison of Established Diagnostic Guidelines in Adults with Respiratory Symptoms

Andrew Simpson, Sarah Drake, Laura Healy, Ran Wang et autres

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Implementing Screening for Depression and Anxiety for Patients with Thyroid Disease

Sarah Drake, Diana Beckmann-Mendez

S42 Diagnosing asthma in children – how can it be improved?

Laura Healy, R Wang, Sarah Drake, Miriam Bennett et autres

Introduction National Institute for Health and Care Excellence (NICE) guideline (NG80) aims to aid asthma diagnosis in children and suggests sequential lung function testing. We compared diagnostic outcomes using NG80 to that of an ‘expert panel’ of respiratory consultants within the Rapid …

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P120 Performance of the NICE, GINA and ERS asthma diagnostic guidelines in adults

A. John Simpson, Sarah Drake, R Wang, Laura Healy et autres

Introduction The under- and over-diagnosis of asthma is widespread and may cause significant risks to patients. There is no single gold standard test to diagnose asthma, and hence there is considerable variability in national and international guidelines. Aim Determine the performance characteristics …

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Sensitivity and Specificity of the 2022 European Respiratory Society (ERS) Guidelines for the Diagnosis of Asthma in Adults

Andrew Simpson, Sarah Drake, Ran Wang, Laura Healy et autres

Introduction: The ERS guidelines propose four pathways to confirm a diagnosis of asthma: i) FEV1/FVC < 75% predicted AND bronchodilator reversibility (BDR) ≥ 12% AND ≥ 200ml, ii) fractional exhaled nitric oxide (FeNO) ≥ 50ppb, iii) peak exploratory flow variability (PEFv) ≥ …

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The impact of time-of-day on the diagnostic performance of tests for asthma

Ran Wang, Stephen Fowler, Robert Maidstone, Laura Healy et autres

Introduction: Asthma is a highly rhythmic disease with most patients experiencing nocturnal worsening. Clinical tests for asthma show diurnal variation, yet current diagnostic strategies do not take this into account. Aim: To investigate the impact of time-of-day on the performance of key …

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Exhaled volatiles to rule out asthma in symptomatic, untreated adults

Ran Wang, Waqar Ahmed, Emma Barrett, Laura Healy et autres

Background: No test for asthma has high enough accuracy to be used in isolation. Office-based tests typically have poor sensitivity due to the variable nature of the disease. Exhaled volatile organic compounds (VOCs) reflect host metabolism and may offer biomarkers reflecting fundamental …

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S35 Treatable traits in symptomatic & untreated children and adults with suspected asthma

Thelma Adjei, R Wang, Laura Healy, Sarah Drake et autres

Background The concept of treatable traits (TTs) has been applied to severe asthma and chronic obstructive pulmonary disease to facilitate the delivery of precision medicine. We hypothesised that this approach might provide clinical useful insights in patients presenting with symptoms suggestive of …

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Is the measurement of particles in exhaled air feasible and useful in children with suspected asthma?

Laura Healy, F Al-Huda, Emma Barrett, L Willmore et autres

Introduction: Particles in exhaled air (PExA©) may differ between adults with asthma and healthy controls but there is limited comparable data in children. Aims: To assess the feasibility of PExA in children and differences between symptomatic children with (A) and without asthma …

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