Robert O. Williams

From Fabrication to Function: Scalable Spray-Assisted Layer-by-Layer Films for Drug Delivery in Glaucoma

Alexandra M. L. Oliveira, Maria Raposo, Sorawee Yanwinitchai, Robert O. Williams et autres

Glaucoma drainage device (GDD) surgery is frequently limited by postoperative fibroblast proliferation, leading to device failure and the need for revision procedures. In this work, we developed a spray-assisted layer-by-layer (LbL) drug delivery system for GDD surfaces intended to enable localized release …

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Effect of thin-film freezing process parameters and excipient composition on mRNA lipid nanoparticles in inhalable powders

Michael A. Sandoval, Qin Li, Ruiqi Shi, Bhupendra R. Giri et autres

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Inhaled dry powders of mRNA polyplexes prepared by thin-film freeze-drying

Bhupendra R. Giri, Younghun Jung, Chaeho Moon, Pramodkumar EK et autres

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From Fabrication to Function: Scalable Spray-Assisted Layer-by-Layer Films for Drug Delivery in Glaucoma

Alexandra M. L. Oliveira, Maria Raposo, Sorawee Yanwinitchai, Robert O. Williams et autres

Glaucoma drainage device (GDD) surgery is frequently limited by postoperative fibro-blast proliferation, leading to device failure and the need for revision procedures. In this work, we developed a spray-assisted layer-by-layer (LbL) drug delivery system for GDD surfaces that enables localized release of …

Evaluation of powder discharge-based KinetiSolTM (pKSD) as a fast and solvent-free particle engineering process for pulmonary drug delivery

Beatriz Behrend-Keim, Miguel O. Jara, Daniel A. Davis, Dave A. Miller et autres

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SedNet: A physics-informed operator-learning framework for rapid sedimentation velocity analytical ultracentrifugation analysis

Andrew Basalla, Krishna Kumar, Zhengrong Cui, Robert O. Williams

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Drum Filling of Thin-Film Freeze-Dried Monoclonal Antibody Powder in UniDose Powder Nasal Spray System

Michael A. Sandoval, Miguel O. Jara, Thomas J. Henry, Bhupendra Raj Giri et autres

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Mentoring the next generations of Pharmaceutical Scientists: credible science

Robert O. Williams

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652 Proteomics of bronchoalveolar lavage fluid in cystic fibrosis ferrets spontaneously colonized by Pseudomonas aeruginosa

Yang Yi, Y. Zhang, G. A. Snow, E. Breyfogle et autres

651 Tracheal swabs and fecal swabs are sensitive surrogates for detecting Pseudomonas Aeruginosa colonization in cystic fibrosis ferrets

Yang Yi, G. A. Snow, Robert O. Williams, E. Breyfogle et autres

Controlled release and extended pulmonary retention of inhaled therapeutics: A review

Sorawee Yanwinitchai, Robert O. Williams

The advancement of controlled release systems for pulmonary therapeutic products has become a significant focus in pharmaceutical research. Various strategies have been employed to regulate the release rate of therapeutic agents, targeting both the release enhancement of poorly water-soluble drugs and prolonging …

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p53-miR-34a feedback in lung fibroblasts regulates antifibrotic effects of CSP7, nintedanib, and pirfenidone

Liang Fan, Rashmi S. Shetty, Huy M. Dao, Akarsha Balnadupete et autres

Pulmonary fibrosis is a progressive and fatal fibroproliferative disease. The current drugs (nintedanib/pirfenidone) only slow clinical progression. Myofibroblasts are the primary effector cells of PF. We found that CSP7, nintedanib and pirfenidone exert antifibrotic effects through restoring p53-microRNA-34a feedback induction in lung …

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