Mario Mauri

NCX2 Targeting as a Neuroprotective Strategy Against Oxaliplatin-Induced Peripheral Neurotoxicity

Sara Di Girolamo, Chiara Invernizzi, Margherita Francesca Kraus, E Ballarini et autres

Background/Objectives: Oxaliplatin (OHP) is a key component of colorectal cancer chemotherapy, but OHP-induced peripheral neurotoxicity (OIPN) is a major dose-limiting adverse effect. OHP-related sodium-channel dysfunction could increase intracellular Na+ and sustain depolarization, conditions that may theoretically favor reverse-mode NCX activity, in which …

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A novel KMT2A::AFF1-derived fusion circRNA regulates mitochondrial metabolism in t(4;11) B-cell acute lymphoblastic leukemia

Doron Tolomeo, Michela Bardini, Santina Venuto, Grazia Visci et autres

The t(4;11) translocation, which drives KMT2A::AFF1 fusion gene expression, is associated with poor prognosis in pediatric and adult B-cell Acute Lymphoblastic Leukemia (B-ALL). KMT2A::AFF1 fusion circular RNAs (f-circRNAs) have been identified in B-ALL, though their contribution to leukemia has not yet been …

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Diesel Exhaust Particles Remodel Lipid Raft-Associated Molecular Features Potentially Relevant to SARS-CoV-2 Susceptibility in A549 Cells

Laura Botto, Mario Mauri, Simone Serrao, Alessandra Bulbarelli et autres

The overlap between the geographic distribution of COVID-19 outbreaks and pollution levels suggested a strong correlation between exposure to atmospheric particulate matter and an increased risk of developing severe forms of disease. This correlation has been highlighted by several epidemiological studies, indicating …

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Anti-Inflammatory Effects of Progesterone on Human Microglia via TLR4/NLRP3 Pathway Modulation: Relevance to Drug-Resistant Epilepsy

Ramona Meanti, Maria Laura Criscione, Emma Sartori, Laura Rizzi et autres

Background: Progesterone (P4) is used as an antiseizure medication (ASM) to treat catamenial epilepsy, refractory to first-line drugs. P4 and other neurosteroids (NSs) are important regulators of multiple nervous system functions, including neuronal excitability and synaptic plasticity. In addition to their antiseizure …

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Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta et autres

BACKGROUND AND PURPOSE: Proteasome inhibitors have been approved for treatment of multiple myeloma but induce significant chemotherapy-related peripheral neurotoxicity in up to one third of patients. Crucial information about the several neurotoxicity mechanisms suggested in the literature and effective triggering events is …

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Fetal-restricted hematopoietic progenitors arise from hemogenic endothelium in vitelline and umbilical arteries

Cristiana Barone, Giulia Quattrini, Alessandro Muratore, Giorgio Anselmi et autres

Embryonic hematopoiesis involves successive waves of progenitors from distinct anatomical sites, but the origins and contributions of early hematopoietic stem and progenitor cells (HSPCs) remain incompletely defined. Here we use genetic fate mapping in mice to temporally label hemogenic endothelium (HE) subsets …

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Meniscal extracellular matrix remodelling caused by injuries and degeneration

Maddalena Bracchi, Riccardo Campanile, Marco Crippa, Mario Mauri et autres

• Multimodal analysis on degenerative, traumatic, and pediatric menisci can reveals ECM composition as driving actor in fucntional alterations • Age-dependent ECM composition has direct impact on morphological and functional differences of menisci • In deepth correlations of mechanical and chemical composition …

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A novel metabolic role of Musashi-2 underlies glucocorticoid resistance in Acute Lymphoblastic Leukemia

Michela Bardini, Luigia Valsecchi, Simona Procopio, Simone Naso et autres

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Raw data for Meniscal extracellular matrix remodelling caused by injuries and degeneration

Maddalena Bracchi, Riccardo Campanile, Marco Crippa, Mario Mauri et autres

This repository contains the raw and processed data supporting the findings of the manuscript:

Raw data for Meniscal extracellular matrix remodelling caused by injuries and degeneration

Maddalena Bracchi, Riccardo Campanile, Marco Crippa, Mario Mauri et autres

This repository contains the raw and processed data supporting the findings of the manuscript:

Sodium-Calcium Exchanger NCX2 Role in Oxaliplatin Induced Peripheral Neurotoxicity Development

Chiara Invernizzi, S Di Girolamo, Alessio Malacrida, V Rodriguez-Menendez et autres

Metronomic 5-Fluorouracil and Vinorelbine Reduce Cancer Stemness and Modulate EZH2/NOTCH-1/STAT3 Signaling in Triple-Negative Breast Cancer Spheroids

Alice Ilari, Emanuela Grassilli, Mario Mauri, Marina Elena Cazzaniga et autres

Triple Negative Breast Cancers (TNBCs) are heterogeneous and aggressive tumors with a median overall survival of less than two years. Despite the availability of new drugs, the prognosis remains poor, implicating a more aggressive clinical course in the metastatic setting. This study …

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