Elsayed Elbasiony

Corneal Myofibroblasts Suppress T-Cell Immunity in Corneal Transplantation

Shudan Wang, Antonio Esquivel Herrera, Elsayed Elbasiony, Seok-Joo Lee et autres

Purpose: To evaluate the immunoregulatory effect of corneal myofibroblasts on effector T cells derived from allogeneic corneal transplant recipient mice. Methods: Allo-primed CD4+CD25- effector T cells isolated from the draining lymph nodes of corneal transplant recipient mice were cocultured with corneal myofibroblasts …

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Calcitonin Gene-Related Peptide Ameliorates Experimental Dry Eye Disease

Zhirong Lin, Bhupender Verma, Shuyan Zhu, Asmaa A. Zidan et autres

Purpose: Calcitonin gene-related peptide (CGRP) level is reduced in the tears of patients with dry eye disease (DED). The current study aims to investigate the expression and therapeutic potential of CGRP as topical eye drops in treating experimental DED. Methods: Human corneal …

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Update on autoimmune retinopathy: diagnosis and management

Elsayed Elbasiony, Jennifer C. W. Hu, Kenneth Matthew McKay, Lucia Sobrin

PURPOSE OF REVIEW: Autoimmune retinopathy (AIR) is a rare but vision-threatening disorder characterized by retinal damage through humoral or cellular immune mechanisms. The purpose of this review is to summarize our current understanding on imaging, antibody testing, and immunosuppressive therapies for AIR. …

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Supersaturated Oxygen Emulsion Mitigates Hypoxia-Driven Corneal Neovascularization after Alkali Burn

Asmaa A. Zidan, Elsayed Elbasiony, Zhirong Lin, Sheyda Najafi et autres

Purpose: Alkali burn is a vision-threatening ocular emergency with no targeted acute therapy. We previously identified tissue hypoxia as a key driver and developed a perfluorodecalin-based supersaturated oxygen emulsion (SSOE) that delivers high levels of oxygen topically. In this study, we aim …

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Topical Hepatocyte Growth Factor Accelerates Wound Healing and Inhibits Scarring in Experimental Corneal Injury

Elsayed Elbasiony, Sharad K. Mittal, Vinay K. Pulimamidi, Tomi Luan et autres

PURPOSE: The aim of this study was to compare the rates of healing, scar formation, and regression of preexisting scars using topical murine hepatocyte growth factor (mHGF), recombinant human deleted HGF (dHGF), murine nerve growth factor (mNGF), and phosphate-buffered saline (PBS). METHODS: …

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Regression of pathological blood vessels by inhibition of mast cell function

Wonkyung Cho, Sharad K. Mittal, Aastha Singh, Elsayed Elbasiony et autres

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Hepatocyte growth factor upregulates MMP1 and MMP10 expression and resolves corneal fibrosis

M. Lee, Elsayed Elbasiony, Wonkyung Cho, Vinay K. Pulimamidi et autres

Different therapeutic modalities, including steroids, have been used to treat corneal scarring. However, the ability of steroids to reduce corneal scarring is limited and associated with numerous side effects. Our previous studies have demonstrated that topical hepatocyte growth factor (HGF) after corneal …

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Topical application of calcitonin gene-related peptide as a regenerative, antifibrotic, and immunomodulatory therapy for corneal injury

Asmaa A. Zidan, Shuyan Zhu, Elsayed Elbasiony, Sheyda Najafi et autres

Calcitonin gene-related peptide (CGRP) is a multifunctional neuropeptide abundantly expressed by corneal nerves. Using a murine model of corneal mechanical injury, we found CGRP levels in the cornea significantly reduced after injury. Topical application of CGRP as an eye drop accelerates corneal …

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Effector T Cells Promote Fibrosis in Corneal Transplantation Failure

Shudan Wang, Sharad K. Mittal, Seok-Joo Lee, Antonio Esquivel Herrera et autres

Purpose: To evaluate whether fibrosis contributes to corneal transplant failure and to determine whether effector CD4+ T cells, the key immune cells in corneal transplant rejection, play a direct role in fibrosis formation. Methods: Allogeneic corneal transplantation was performed in mice. Graft …

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Topical application of calcitonin gene-related peptide as a regenerative, antifibrotic, and immunomodulatory therapy for corneal injury

Asmaa A. Zidan, Shuyan Zhu, Elsayed Elbasiony, Sheyda Najafi et autres

Calcitonin gene-related peptide (CGRP) is a multifunctional neuropeptide abundantly expressed by corneal nerves. Using a murine model of corneal mechanical injury, we found CGRP levels in the cornea to be significantly reduced after injury. Topical application of CGRP as an eye drop …

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Increased activity of lacrimal gland mast cells are associated with corneal epitheliopathy in aged mice

Elsayed Elbasiony, Wonkyung Cho, Aastha Singh, Sharad K. Mittal et autres

Abstract The lacrimal gland undergoes significant structural and functional deterioration with aging. Marked with increased inflammation and fibrosis, the aged lacrimal gland is unable to perform its protective function. As a result, the ocular surface becomes highly susceptible to various ocular surface …

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IL-36γ Augments Ocular Angiogenesis by Promoting the Vascular Endothelial Growth Factor–Vascular Endothelial Growth Factor Receptor Axis

Wonkyung Cho, Elsayed Elbasiony, Aastha Singh, Sharad K. Mittal et autres

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