Martin Langeskov‐Christensen

Premorbid depression across levodopa equivalent daily dose-defined treatment trajectories in Parkinson's disease: A nationwide register-based cohort study

Martin Langeskov‐Christensen, Per Borghammer, Søren Dinesen Østergaard, Christopher B. Rohde

BACKGROUND: Depression is a common comorbidity in Parkinson's disease (PD) and may precede diagnosis by several years. It remains unclear whether prodromal depression is associated with specific PD subtypes or faster disease progression. We investigated whether pre-diagnostic depression incidence differs according to …

dk (code pays fourni par la source)

Responsiveness of the Timed ‘Up and Go’ test in people with Parkinson's disease

John Kodal Brincks, Jens Bansi, Martin Langeskov‐Christensen, Ulrik Dalgas et autres

Objectives This study evaluates the responsiveness of the Timed ‘Up and Go’ test in people with Parkinson’s disease to determine its sensitivity in detecting changes in functional mobility. Design Retrospective cohort study. Setting Inpatient rehabilitation. Participants One hundred ninety-six people with Parkinson's …

dk, ch, nl (code pays fourni par la source)

Response to the letter to the editor: “Maximal aerobic capacity (VO 2 max) in Parkinson’s disease compared to healthy controls: the importance of nuanced interpretation”

Cecilie Thrue, Lars G. Hvid, Mads Gamborg, Helen Dawes et autres

Accurate interpretation of VO₂max in Parkinson’s disease requires consideration of multiple physiological and methodological factors rather than any single determinant.Exercise professionals should...

dk (code pays fourni par la source)

Exercise-induced modulation of kynurenine pathway metabolite patterns in multiple sclerosis: a targeted metabolomics analysis across four randomized controlled trials

Marie Kupjetz, Martin Langeskov‐Christensen, Morten Riemenschneider, Stefan Inerle et autres

Kynurenine pathway imbalance is a characteristic feature of multiple sclerosis (MS). Serum kynurenines contribute to latent factors reflecting a neurotoxic (NeuroTox) or neuroprotective pattern (NeuroPro). Previous single-metabolite studies show a favorable modulation of the kynurenine pathway by acute exercise, characterized by increased …

de, dk, ch, no (code pays fourni par la source)

Exercise and Pain in Multiple Sclerosis, Parkinson’s Disease, Alzheimer’s Disease, and Stroke: A Systematic Review and Meta-analysis

Victor Kornum Baccaro, Lars G. Hvid, Rasmus C Jungersen, Martin Langeskov‐Christensen

dk (code pays fourni par la source)

Physical activity and exercise participation—Impact on motor and non‐motor outcomes in early‐stage Parkinson disease: A cross‐sectional study

Cecilie Thrue, Frederik Bonde-Jensen, Lars G. Hvid, Ulrik Dalgas et autres

BACKGROUND: Aerobic exercise is beneficial in managing Parkinson disease (PD), yet its potential remains less clear in early stages. This study investigates the impact of long-term aerobic exercise habits in individuals with early-stage PD compared with healthy controls. DESIGN: Cross-sectional study. OBJECTIVES: …

dk (code pays fourni par la source)

COVID ‐19–Induced Narcolepsy Type I With Cataplexy: A Short Report

Torsten Vinding Merinder, Martin Langeskov‐Christensen, F. Kirov

Narcolepsy type I is a rare neurological sleep disorder characterised by chronic excessive daytime sleepiness, cataplexy, and low orexin (hypocretin) levels. Infection with SARS-CoV-2 has been linked to neurological and neuropsychiatric sequelae, but cases of post-COVID narcolepsy remain extremely uncommon. We report …

dk (code pays fourni par la source)

Efficacy of Aerobic Exercise on Brain MRI Measures in Parkinson’s Disease

Martin Langeskov‐Christensen, Mikkel Karl Emil Nygaard, Simon Fristed Eskildsen, Steffen Ringgaard et autres

OBJECTIVES: Medical disease-modifying treatments are lacking in Parkinson's disease (PD). Physical exercise is potentially an inexpensive and easily accessible disease-modifying therapy, but this remains to be studied using recent promising magnetic resonance imaging (MRI) markers of disease progression. The objective was to …

dk (code pays fourni par la source)

Evaluating maximal oxygen uptake in exercise-based cardiac rehabilitation

Claus Theilgaard Sevel, Ulrik Dalgas, Martin Langeskov‐Christensen, Thomas Maribo

Purpose Maximal oxygen uptake (VO2max) is a strong, independent predictor of both all-cause and disease-specific mortality, making it a key health and performance marker for individuals with heart disease. While cardiopulmonary exercise testing is the gold standard for determining VO2max, its use …

dk (code pays fourni par la source)

Effects of supervised progressive resistance training on corticospinal excitability in persons with multiple sclerosis: A randomized controlled trial protocol for the NEXIMS study

Therese M. Andersen, Hjalte Riis, Hatice Tankisi, Sepehr Mamoei et autres

BACKGROUND: Neurodegeneration is a hallmark of multiple sclerosis (MS) that affects both the structure (e.g., total or regional brain volume) and function (e.g., corticospinal excitability) of the central nervous system (CNS), driving disability progression. Consequently, lower extremity neuromuscular function and physical function …

dk (code pays fourni par la source)

Depression preceding and following the diagnosis of Parkinson’s disease and Lewy body dementia

Christopher B. Rohde, Martin Langeskov‐Christensen, Lene Bastrup Jørgensen, Per Borghammer et autres

Background: Depression is a common comorbidity in Parkinson's disease (PD) and Lewy body dementia (LBD). However, studies examining the rate of incident depression in the period preceding and following the diagnosis of PD and LBD are lacking in the literature. Aims: To …

dk (code pays fourni par la source)

Effects of oral levodopa on motor symptoms and gait impairments in Parkinson’s disease: a systematic review and meta-analysis

Birk S. Lillebæk, Ulrik Dalgas, Martin Langeskov‐Christensen

INTRODUCTION: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and gait impairments. Levodopa remains the cornerstone of pharmacological treatment. This review examined the acute effects of oral levodopa on motor symptoms and gait parameters in people with PD. METHODS: …

dk (code pays fourni par la source)