Dana Zakalik

Projected Benefit of Bilateral Salpingo-Oophorectomy by Age in BRCA Carriers

Vasily Giannakeas, Adriana I. Apostol, Claudia Diella, Nupur Dave et autres

Importance: Women with a BRCA1 or BRCA2 variant face a high lifetime risk of ovarian cancer and are often advised to undergo preventive surgery (bilateral salpingo-oophorectomy [BSO]) before cancer develops. The recommended age of BSO is 35 years for BRCA1 carriers and …

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Lynch syndrome integrative epidemiology and genetics (LINEAGE): rationale for cohort design

Swati G. Patel, Holli Ann Loomans-Kropp, Zachariah H. Foda, Bryson W. Katona et autres

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Risk of Breast Cancer After Ovarian Cancer in Women With a Pathogenic/Likely Pathogenic Variant in BRCA1 or BRCA2

Adriana Ionelia Apostol, Jacek Gronwald, Cezary Cybulski, Raymond H. Kim et autres

PURPOSE BRCA carriers face high risks of developing both breast and ovarian/fallopian tube cancers (hereafter referred to as ovarian ). Among BRCA carriers with ovarian cancer, it is not clear whether the risk of breast cancer is sufficiently high that risk-reducing mastectomy …

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Abstract GS3-01: Menopausal Hormone Therapy and the Risk of Breast Cancer in Women with a Pathogenic Variant in BRCA1 or BRCA2

J. Kotsopoulos, M. Seca, G. Jacek, T. Huzarski et autres

Abstract Background: Women with a pathogenic variant in the BRCA1 or BRCA2 gene (carriers) are at a high risk of developing ovarian cancer and recommended to undergo bilateral salpingo-oophorectomy at an early age resulting in surgical menopause. Menopausal hormone therapy (MHT) is …

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Risk of ovarian cancer among women with a pathogenic variant in BRCA1 according to mutation type and location

Joanne Kotsopoulos, Adriana I. Apostol, Dimitri Jorgji, Cezary Cybulski et autres

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The risk of breast cancer following ovarian cancer in women with a pathogenic mutation in BRCA1 or BRCA2

Adriana I. Apostol, Jacek Gronwald, Cezary Cybulski, Raymond H. Kim et autres

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The Risk of Breast Cancer According to Mutation Type and Position in Carriers of a Pathogenic Variant in BRCA1

Joanne Kotsopoulos, Adriana Ionelia Apostol, Kelly A. Metcalfe, Dimitri Jorgji et autres

Background: Carriers of a pathogenic variant (PV) in BRCA1 face a high risk of breast cancer. This study estimated the risk of developing breast cancer according to mutation type and location. Methods: BRCA1 carriers with no personal history of breast cancer or …

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Menopausal hormone therapy and the risk of breast cancer in women with a pathogenic variant in BRCA1 or BRCA2

Joanne Kotsopoulos, Marta Seca, Jacek Gronwald, Tomasz Huzarski et autres

BACKGROUND: Women with a pathogenic variant in BRCA1 or BRCA2 are at high risk of developing ovarian cancer, and it is often recommended that they undergo bilateral salpingo-oophorectomy at an early age, resulting in surgical menopause. Menopausal hormone replacement therapy (HRT) is …

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Endometriosis in Carriers of a Pathogenic Variant in BRCA1 or BRCA2: A Descriptive Analysis of a Large Multicentral BRCA Carrier Cohort

Aghaghia Mokhber, Bethany Stewart, Kathryn L. Terry, Jacek Gronwald et autres

Background: Endometriosis affects an estimated 10% of reproductive-aged women and is associated with increased ovarian cancer risk. While BRCA1/2 mutations are established risk factors for ovarian cancer, their association with endometriosis remains unclear. This study aimed to characterize the prevalence and clinical …

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Areas of Uncertainty in Pancreatic Cancer Surveillance: A Survey Across the International Pancreatic Cancer Early Detection (PRECEDE) Consortium

Anjeli Manam, Jessica N. Everett, Sigurdís Haraldsdóttir, Phil A. Hart et autres

PURPOSE Pancreatic cancer (PC) surveillance is increasingly recommended for high-risk individuals, but there are remaining areas of uncertainty that are not consistently addressed by guidelines contributing to heterogeneity in clinical practice. Herein, we compare PC surveillance practices across sites in the international …

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Case Report: Androgen receptor-positive, locoregionally advanced breast cancer in a transgender man and an update on breast cancer management in a gender-diverse patient population

Yastira Ramdas, Trenton Reinicke, Carolyn A. Schnurr, Laura Nadeau et autres

The role of androgen receptor (AR) signaling in breast cancer is underexplored and may be particularly important in the treatment of patients with higher levels of circulating androgens. We discuss the management of a 70-year-old, postmenopausal transgender man with a six-and-one-half-year history …

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Ovarian cancer after breast cancer in women with a BRCA1 or BRCA2 pathogenic variant

Adriana Ionelia Apostol, Joanne Kotsopoulos, Jacek Gronwald, Raymond H. Kim et autres

it, ca, pl, us, es, at, no (code pays fourni par la source)