Ricardo Hernández-Morales

Precellular System Models and the Struggle Against Reductionism: Revisiting a Scientific and Philosophical Debate

José Alberto Campillo-Balderas, Ricardo Hernández-Morales, Antonio Lazcano

This article provides a discussion of the scientific, intellectual, and ideological frameworks that influenced Oparin's formulation of the heterotrophic theory of the origin of life. Based on a Darwinian perspective, Oparin rejected the generally accepted idea that the first entities were photosynthetic …

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Methyl-coenzyme M reductase in archaeal methanogenesis: evolution, mechanism, and biotechnological perspectives

Alberto Vázquez-Salazar, Ricardo Hernández-Morales, Edgar Mixcoha, Ricardo Muñiz-Trejo et autres

Methanogenesis is an anaerobic, energy-conserving metabolism that converts CO 2 , acetate, and methylated compounds to methane, constituting a key terminal step in the mineralization of organic matter in many oxygen-limited ecosystems. In the modern biosphere, biological methane formation is overwhelmingly dominated …

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Studying the Evolution of Protein Structure One Superfamily at a Time

Adrián Cruz-González, Ricardo Hernández-Morales, José Alberto Campillo-Balderas, Rodrigo Jácome

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Protein Architecture Comparisons and the Reconstruction of the Last Universal Common Ancestor (LUCA)

Ricardo Hernández-Morales, Coral C G Luna, Antonio Lazcano, Arturo Becerra

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Can the origin of biosynthetic routes be explained by a Frankenstein’s monster-like spontaneous assembly of prebiotic reactants?

Alicia Negrón-Mendoza, Ricardo Hernández-Morales, Antonio Lazcano

Since it is easy to envision that prebiotically synthesized molecules underwent reactions comparable or even identical to those that occur in some metabolic pathways, it has been argued that biosynthetic routes emerged from the direct assembly of these prebiotic reactants. However, although …

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Chapter 1: The Astrobiology Primer 3.0

Micah J. Schaible, Nadia Szeinbaum, Gonensin Ozan Bozdag, Luoth Chou et autres

The Astrobiology Primer 3.0 (ABP3.0) is a concise introduction to the field of astrobiology for students and others who are new to the field of astrobiology. It provides an entry into the broader materials in this supplementary issue of Astrobiology and an …

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Chapter 2: What Is Life?

Stephanie M. Colón‐Santos, Alberto Vázquez-Salazar, Alyssa Adams, José Alberto Campillo-Balderas et autres

The question "What is life?" has existed since the beginning of recorded history. However, the scientific and philosophical contexts of this question have changed and been refined as advancements in technology have revealed both fine details and broad connections in the network …

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Pioneering role of RNA in the early evolution of life

Israel Muñoz‐Velasco, Adrián Cruz-González, Ricardo Hernández-Morales, José Alberto Campillo-Balderas et autres

The catalytic, regulatory and structural properties of RNA, combined with their extraordinary ubiquity in cellular processes, are consistent with the proposal that this molecule played a much more conspicuous role in heredity and metabolism during the early stages of biological evolution. This …

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Two short low complexity regions (LCRs) are hallmark sequences of the Delta SARS-CoV-2 variant spike protein

Arturo Becerra, Israel Muñoz‐Velasco, Abelardo Aguilar-Cámara, Wolfgang Cottom-Salas et autres

Low complexity regions (LCRs) are protein sequences formed by a set of compositionally biased residues. LCRs are extremely abundant in cellular proteins and have also been reported in viruses, where they may partake in evasion of the host immune system. Analyses of …

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Subtle structural differences of nucleotide analogs may impact SARS-CoV-2 RNA-dependent RNA polymerase and exoribonuclease activity

Abraham Madariaga‐Mazón, J. Jesús Naveja, Arturo Becerra, José Alberto Campillo-Balderas et autres

The rapid spread and public health impact of the novel SARS-CoV-2 variants that cause COVID-19 continue to produce major global impacts and social distress. Several vaccines were developed in record time to prevent and limit the spread of the infection, thus playing …

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Structural biology of the SARS-CoV-2 replisome: evolutionary and therapeutic implications

Ricardo Hernández-Morales, Arturo Becerra, José Alberto Campillo-Balderas, Wolfgang Cottom-Salas et autres

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List of contributors

Ana C. Alcalá, C. Almendarez-Rodríguez, J.M. Alvarado-Orozco, Julio Y. Anaya-Covarrubias et autres

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