Patrizia Andreozzi

Poly(allylamine)-based carriers for gene and drug delivery: Chemical functionalization, structure-function relationships, and biointerface interactions

Francesca Milano, Sofia Zuffi, Chanchai Boonla, Patrizia Andreozzi et autres

Poly(allylamine) (PAH) is a cationic polymer that has attracted increasing interest for biomedical applications due to its high density of reactive primary amines and intrinsic pH responsiveness. While PAH has been primarily investigated as a non-viral gene delivery vector, its broader potential …

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Linear Polyethyleneimine-Coated Gold Nanoparticles as a Platform for Central Nervous System Targeting

Agustín Jesús Byrne, Antonia Infantes-Molina, Enrique Rodrı́guez-Castellón, Romina Julieta Glisoni et autres

The unique physicochemical properties of gold nanoparticles (GNPs) have made them versatile tools for biomedical applications, such as imaging, therapy, and drug delivery. The surface modification of GNPs with polymers or biomolecules can enhance their colloidal stability and facilitate internalization into cells. …

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Glucose-functionalized gold nanoparticles for effective photothermal therapy in lung cancer

Juan Braga Menéndez, Mariel Fusco, Flavia Piccioni, Constanza Arriola Benítez et autres

Lung cancer remains the leading cause of cancer-related mortality worldwide, largely due to late-stage diagnoses that severely limit therapeutic interventions. In this context, nanoparticle-mediated photothermal therapy (PTT) has emerged as a promising and minimally toxic modality for solid tumors. We synthesized gold …

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Phagophores are formed from multilamellar organelles which originate from the outer mitochondrial membrane following mitochondrial fusion

Mateja Erdani Kreft, Alexandre Mironov, Galina V. Beznoussenko, Larisa Tratnjek et autres

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Silica‐Based Hybrid Nano Assemblies Prepared by the LbL Technique with Combined Functionalities for Photothermal and Photodynamic Therapies

Joaquín E. Martínez Porcel, Patrizia Andreozzi, Daniel C. Castrogiovanni, Gabriela N. Bosio et autres

Abstract Photodynamic therapy (PDT) and photothermal therapy (PTT) rely on light to generate reactive oxygen species and heat. Both can be applied for cancer treatment and can be combined for an enhanced outcome. Here, we develop multifunctional colloidal composites based on the …

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Glucose-functionalized gold nanoparticles for effective photothermal therapy in lung cancer

Juan Braga Menendez, Mariel Fusco, Flavia Piccioni, Paula Constanza Arriola Benitez et autres

Lung cancer remains the leading cause of cancer-related mortality worldwide, largely due to latestage diagnoses that severely limit therapeutic interventions. In this context, nanoparticle-mediated photothermal therapy (PTT) has emerged as a promising and minimally toxic modality for solid tumors. We synthesized gold …

Glyconanocapsules with pH Responsiveness for Encapsulation and Smart Delivery of Therapeutics

Francesca Milano, Francesca Buco, Andrea Goti, Patrizia Andreozzi et autres

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Supramolecular dextran/polyamine phosphate nanocapsules with smart responsiveness for encapsulation of therapeutics

Aharon Steffè, Francesca Milano, Santiago Giménez Reyes, Francesca Buco et autres

polymers form supramolecular assemblies. Physico chemical characteristics and pH responsiveness of the assemblies are correlated with the number of dextran chains per PAH molecule. Nanocapsules (NCs) are formed when PAH:DEX ratio is 1. Capsule formation is explained by the branched nature of …

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A study of complexation and biological fate of polyethyleneimine-siRNA polyplexes in vitro and in vivo by fluorescence correlation spectroscopy and positron emission tomography imaging

Tanja Ursula Lüdtke, Cristina Simó, Santiago Giménez Reyes, Marta Martinez Moro et autres

Fluorescence correlation spectroscopy and positron emission tomography are used to study the formation of PEI siRNA polyplex nanoparticles and to trace their biological fate at cell level and in vivo .

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Biocompatible cellulose nanocrystal-based Trojan horse enables targeted delivery of nano-Au radiosensitizers to triple negative breast cancer cells

Giacomo Biagiotti, Riccardo Cazzoli, Patrizia Andreozzi, Giusi Aresta et autres

gold nanoparticles (AuNPs) into triple negative breast cancer (TNBC) cells. This "Trojan horse" approach promotes a specific and massive accumulation of radiosensitizers in TNBC cells, thus avoiding the fast turnover of small-sized AuNPs and the need for high doses of AuNPs for …

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Supramolecular Dextran/Polyamine Phosphate Nanocapsules with Smart Responsiveness for Encapsulation of Therapeutics

Marco Marradi, Aharon Steffè, Francesca Milano, Santiago Giménez Reyes et autres

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pH-Responsive Poly(allylamine)/Dextran Nanocapsules: A Versatile Platform For Encapsulation and Delivery of Biologics

Francesca Milano, Francesca Buco, Patrizia Andreozzi, Marco Marradi

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