J. Soni

Quantifying the Energetics of Protein-Mediated Stabilization of Membrane Deformation

Rupam Dey, J. Soni, Taraknath Mandal

Membrane curvature plays a central role in a wide range of biological processes, yet a quantitative and transferable description of its underlying energetics remains challenging. In this work, we develop a "reaction coordinate" within the Umbrella-Sampling framework to compute the free-energy cost …

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Intricate Role of Cholesterol in Membrane Fusion

J. Soni, Rupam Dey, Taraknath Mandal

Cholesterol, having diverse effects in membrane deformation, can either promote or inhibit membrane fusion, as suggested by many experimental studies of protein-mediated fusion. Here, we examine the energetics of fusion intermediates and find that cholesterol modulates the fusion energy landscape in a …

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BACTERIOLOGICAL ETIOLOGY OF EAR INFECTION AND THEIR ANTIBACTERIAL SUSCEPTIBILITY PATTERN AT A TERTIARY CARE CENTRE IN NORTHEN INDIA

J. Soni, Sana Jamali

A Systematic Review and Meta-Analysis of the Prevalence and Antimicrobial Resistance Patterns of ESBL-Producing Uropathogens in India

J. Soni, Dr. Sheetal Sharma, Akriti Sharma, Kaushal Kishore

Human Microbiome and Neurodevelopmental Disorders

J. Soni, Akriti Sharma, Aniruddha Sen

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Hospital-Acquired Infections

J. Soni, Akriti Sharma, Aniruddha Sen

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Human Microbiome and Neurodevelopmental Disorders

J. Soni, Akriti Sharma, Aniruddha Sen

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Hospital-Acquired Infections

J. Soni, Akriti Sharma, Aniruddha Sen

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Investigating the Impact of Cholesterol on GP41-Driven HIV Membrane Fusion

J. Soni, Taraknath Mandal

Membrane fusion is a critical step in HIV infection, allowing the virus envelope to merge with the host cell membrane and deliver genetic material. Cholesterol is believed to play a pivotal role in HIV fusion; however, the specific mechanism by which it …

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The Surface-Topography Challenge: A Multi-Laboratory Benchmark Study to Advance the Characterization of Topography

Asima Pradhan, Martin H. Müser, N. Miller, Juan Pablo Abdelnabe et autres

a, the average absolute deviation of the height from the mean line (at some, not necessarily known or specified, lateral length scale). However, other parameters, particularly those that are scale-dependent, influence surface and interfacial properties; for example the local surface slope is …

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Neurotransmitter Dysregulation in Personality Disorders

J. Soni, Aniruddha Sen

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Origin of the nonlinear structural and mechanical properties in oppositely curved lipid mixtures

Shivam Gupta, J. Soni, Awneesh Kumar, Taraknath Mandal

Structural and mechanical properties of membranes such as thickness, tail order, bending modulus and curvature energetics play crucial role in controlling various cellular functions that depend on the local lipid organization and membrane reshaping. While behavior of these biophysical properties are well …

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