Grace E. Kunkel

Electronic Effects of Bidentate P , N -Ligands on the Elementary Steps of Au(I)/Au(III) Reactions Relevant to Cross-Coupling Chemistry

Joseph W. Treacy, Elaine Y. Chao, Grace E. Kunkel, Thomas Louis-Goff et autres

High Resolution Image Download MS PowerPoint Slide Oxidant-free Au(I)/Au(III)-catalyzed cross-coupling has been recently enabled by the use of bidentate P, N -ligands. To further develop these P, N -ligands, computational studies were performed to understand their effects on the oxidative addition of …

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Heterotelechelic Organometallic PEG Reagents Enable Modular Access to Complex Bioconjugates

Grace E. Kunkel, Joseph W. Treacy, Magdalena F. Polite, Hayden R. Montgomery et autres

Organometallic oxidative addition complexes (OACs) have recently emerged as a powerful class of reagents for the rapid and chemoselective modification of biomolecules. Notably, the steric and electronic properties of the ligand and aryl group can be modified to tune the kinetic profile …

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Electronic Effects of Bidentate P,N-Ligands on the Elementary Steps of Au(I)/Au(III) Reactions Relevant to Cross-Coupling Chemistry

Joseph W. Treacy, Elaine Y. Chao, Grace E. Kunkel, Thomas Louis-Goff et autres

Oxidant-free Au(I)/Au(III) catalyzed cross-coupling has been recently enabled by the use of bidentate P,N-ligands. To further develop these P,N-ligands, computational studies were performed to understand their effects on the oxidative addition of aryl iodide electrophiles with Au(I). Using this mechanistic understanding, six …

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Heterotelechelic Organometallic PEG Reagents Enable Modular Access to Complex Bioconjugates

Grace E. Kunkel, Joseph W. Treacy, Magdalena F. Polite, Hayden R. Montgomery et autres

Organometallic oxidative addition complexes (OACs) have recently emerged as a powerful class of reagents for the rapid and chemoselective modification of biomolecules. Notably, the steric and electronic properties of the ligand and aryl group can be modified to tune the kinetic profile …

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Polymer-mediated protein/peptide therapeutic stabilization: Current progress and future directions

Katherine Snell, Grace E. Kunkel, Panagiotis G. Georgiou, Ellie G. Puente et autres

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Comparison of Cyclic and Linear PEG Conjugates

Grace E. Kunkel, Qingyang Zhou, Joseph W. Treacy, Hayden R. Montgomery et autres

Bioconjugation of polymers to proteins is a method to impart improved stability and pharmacokinetic properties to biologic systems. However, the precise effects of polymer architecture on the resulting bioconjugates are not well understood. Particularly, cyclic polymers are known to possess unique features …

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Ultrafast Au(III)-Mediated Arylation of Cysteine

Evan A. Doud, James A. R. Tilden, Joseph W. Treacy, Elaine Y. Chao et autres

Through mechanistic work and rational design, we have developed the fastest organometallic abiotic Cys bioconjugation. As a result, the developed organometallic Au(III) bioconjugation reagents enable selective labeling of Cys moieties down to picomolar concentrations and allow for the rapid construction of complex …

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Efficient end-group functionalization and diblock copolymer synthesis via Au( iii ) polymer reagents

Grace E. Kunkel, Joseph W. Treacy, Hayden R. Montgomery, Ellie G. Puente et autres

-arylation of thiol-containing small molecules and polymers to yield functionalized mono-telechelic polymers and diblock copolymers, respectively. These transformations proceed rapidly within minutes and produce conjugates in quantitative conversion, making this strategy a robust addition to the polymer functionalization toolbox.

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Breaking Kinetic Record for Cysteine Bioconjugation with Organometallic Reagents

Evan A. Doud, James A. R. Tilden, Joseph W. Treacy, Elaine Y. Chao et autres

Through mechanistic work and rational design, we have developed the fastest abiotic Cys bioconjugation. As a result, the developed organometallic Au(III) bioconjugation reagents enable selective labelling of Cys moieties down to pM concentrations and allow for the rapid construction of complex heterostructures …

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Pesticides in honey bee colonies: Establishing a baseline for real world exposure over seven years in the USA

Kirsten S. Traynor, Simone Tosi, Karen Rennich, Nathalie Steinhauer et autres

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Synthetic versatility, reaction pathway, and thermal stability of tetrahedrite nanoparticles

Christine D. Fasana, Mitchel S. Jensen, Graciela E. García Ponte, Tyler R. MacAlister et autres

A modified polyol process produces undoped and doped tetrahedrite. Bottom-up solution-phase formation of nanomaterial is investigated. Impact of nanostructuring and doping on thermal properties is evaluated.

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Observation of n-type behavior in Fe-doped tetrahedrite at low temperature

Daniel P. Weller, Grace E. Kunkel, Andrew M. Ochs, Donald T. Morelli et autres

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