Petros S. Tzimas

Mitigating CYP450-Mediated Insecticide Resistance in Malaria Vectors with Cannabis-Derived Synergists: The Potential of Cannabidiol

Maria Chalkiadaki, Linda Grigoraki, Dimitra Tsakireli, Georgia Vasalaki et autres

Abstract Insecticide resistance in mosquitoes, largely mediated by cytochrome P450 monooxygenases (CYPs), compromises the efficacy of vector control tools. In this study, chemically-wise selected natural extracts and compounds were screened for their CYP inhibition potential. Among 37 tested plant extracts and fractions, …

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Online dried spot LC-Orbitrap analysis for the quality assessment of cannabis products

Varvara Papaioannou, Petros S. Tzimas, Stavros Beteinakis, Leandros Alexios Skaltsounis et autres

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Introducing dried spot techniques in food characterization: The case of red wine

Ioanna Deli, Petros S. Tzimas, Stavros Beteinakis, Maria Halabalaki

Food quality, interrogated by analytical methods, is a prerequisite of modern societies' well-being. However, analysis is greatly compromised at the sampling and sample preparation stages, which are typically resource-intensive and tedious. Dried spot microsampling on paper cards, used almost exclusively for dried …

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Evaluation of European-developed hemp cultivars (Cannabis sativa L.) in response to water regimes

Angeliki Kousta, Panayiota T. Papastylianou, Petros S. Tzimas, Alexios‐Léandros Skaltsounis et autres

Aim of study: The present study aimed to evaluate the effect of water deficit on the growth and yield of hemp (Cannabis sativa L.) cultivars under semi-arid Mediterranean conditions. Area of study: Southern Greece, Athens. Material and methods: Three different irrigation regimes …

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Uncovering the metabolite complexity and variability of cultivated hemp (Cannabis sativa L.): A first phytochemical diversity mapping in Greece

Petros S. Tzimas, Stavros Beteinakis, Eleftherios A. Petrakis, Panayiota T. Papastylianou et autres

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Extraction solvent selection for Cannabis sativa L. by efficient exploration of cannabinoid selectivity and phytochemical diversity

Petros S. Tzimas, Eleftherios A. Petrakis, Maria Halabalaki, Leandros Alexios Skaltsounis

INTRODUCTION: Cannabis sativa L. is attracting worldwide attention due to various health-promoting effects. Extraction solvent type is critical for the recovery of bioactive compounds from the plant, especially cannabinoids. However, the choice of solvent is varied and not adequately warranted elsewhere, causing …

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Comprehensive methodology for characterization of Cannabis sativa L. (hemp) inflorescences through combined NMR and LC-based metabolite profiling

Petros S. Tzimas, Eleftherios A. Petrakis, Stavros Beteinakis, Panayiota T. Papastylianou et autres

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Analytical and chemometric approaches for quality characterization of Cannabis sativa L. with focus on cannabinoids

Petros S. Tzimas, Eleftherios A. Petrakis, A Papadimitriou, S. Beteinakis et autres

The quality characterization of Cannabis sativa L., especially with respect to its containing cannabinoids, is associated with many analytical challenges. Within this context, the power of chemometrics is recognized for interpretation and optimization of analytical procedures [ 1 ], as was undertaken …

Effective determination of the principal non-psychoactive cannabinoids in fiber-type Cannabis sativa L. by UPLC-PDA following a comprehensive design and optimization of extraction methodology

Petros S. Tzimas, Eleftherios A. Petrakis, Maria Halabalaki, Leandros Alexios Skaltsounis

Cannabidiol (CBD) and cannabidiolic acid (CBDA) represent the most abundant non-psychoactive cannabinoids in fiber-type Cannabis sativa L. (hemp) and both have demonstrated high therapeutic potential. Hence, efficient extraction coupled with reliable determination of these compounds is crucial for informed utilization of hemp …

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Cannabidiol Modulates the Motor Profile and NMDA Receptor-related Alterations Induced by Ketamine

Charalampos Brakatselos, Foteini Delis, Michail-Zois Asprogerakas, Panagiotis Lekkas et autres

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