Adolf Slaby

FADS Polymorphisms Affect the Clinical and Biochemical Phenotypes of Metabolic Syndrome

Aleš Žák, M Jáchymová, Michal Burda, Barbora Staňková et autres

Long-chain polyunsaturated fatty acids (LC-PUFAs) play important roles in human health, from controlling inflammation to lipid and glucose homeostasis. In our previous study, which employed a cluster analysis of a plasma fatty acid (FA) pattern, we identified two clusters of metabolic syndrome …

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Polymorphisms rs2167444 and rs508384 in the SCD1 Gene Are Linked with High ApoB-48 Levels and Adverse Profile of Cardiometabolic Risk Factors

Barbora Staňková, Jaroslav Macášek, M. Zeman, Marek Vecka et autres

Elevated plasma concentration of apolipoprotein B-48 (apoB-48) is an independent risk factor of cardiovascular disease. Stearoyl-CoA desaturase-1 (SCD1) is a rate-limiting lipogenic enzyme and a key regulator of fuel metabolism. The aim of this study was to analyse associations between clinical, biochemical, …

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Polymorphisms of SCD-1 gene, increased oxidative stress and insulin resistance in persons with elevated concentrations of apolipoprotein B48

Barbora Staňková, Jaroslav Macášek, M. Zeman, Marek Vecka et autres

[Desaturases of fatty acids (FADS) and their physiological and clinical implication].

Aleš Žák, Adolf Slaby, EVA TVRZICKÁ, M Jáchymová et autres

States associated with insulin resistance, as overweight/obesity, type 2 diabetes mellitus (DM2), cardiovascular diseases (CVD), some cancers and neuropsychiatric diseases are characterized with a decrease of long-chain polyunsaturated fatty acids (LC-PUFA) levels. Amounts of LC-PUFA depend on the exogenous intake of their …

Xanthomas: Clinical and pathophysiological relations

Aleš Žák, M. Zeman, Adolf Slaby, Marek Vecka

BACKGROUND: Xanthomas are well circumscribed lesions in the connective tissue of the skin, tendons or fasciae that predominantly consist of foam cells; these specific cells are formed from macrophages as a result of an excessive uptake of low density lipoprotein (LDL) particles …

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Paraoxonase-1 (PON1) Status in Pancreatic Cancer: Relation to Clinical Parameters

Marek Vecka, M Jáchymová, Lucie Vávřová, Jana Kodydková et autres

Human paraoxonase 1 (PON1) has been shown to decrease the level of systemic oxidative stress, which is thought to contribute to cancer development. The aim of this study was to examine the interrelationships between PON1 status and some clinical characteristics in patients …

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N-3 polyunsaturated fatty acids in the treatment of atherogenic dyslipidemia.

Marek Vecka, Magdaléna Dušejovská, Barbora Staňková, M. Zeman et autres

BACKGROUND: Atherogenic dyslipidemia contributes substantially to the residual cardiovascular risk. The aim of this study was to examine the effects of therapeutic doses of n-3 polyunsaturated fatty acids on the three major lipid abnormalities of atherogenic dyslipidemia, i.e. hypertriacylglycerolemia, low HDL cholesterol, …

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Paraoxonase-1 (PON1) Status in Pancreatic Cancer: Relation to Clinical Parameters (pancreaticcancer/paraoxonase1(PON1)polymorphisms/PON1arylesterase/lactonaseactivities/ malnutrition)

Marek Vecka, M Jáchymová, Lucie Vávřová, Jana Kodydková et autres

Human paraoxonase 1 (PON1) has been shown to decrease the level of systemic oxidative stress, which is thought to contribute to cancer devel- opment. The aim of this study was to examine the interrelationships between PON1 status and some clinical characteristics in …

[Renin, prorenin, and the direct renin inhibitor aliskiren].

Adolf Slaby, Aleš Žák

The renin-angiotensin system plays an important role in various physiological and pathophysiological regulatory mechanisms. Within the past few years, the classical concept of a linear enzymatic cascade has experienced substantial changes. A parallel counterregulatory axis has been identified which involves the angiotensin …

[On the concept of the metabolic syndrome].

Aleš Žák, Adolf Slaby

During the last twenty years, a cluster of risk factors called metabolic syndrome (MetS) attracts interest in preventive medicine. According to the prevailing notion, which evolved from clinical observations, the core of the MetS consists of visceral obesity, impaired metabolism of glucose, …

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The influence of polymorphism of −493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress

Aleš Žák, M Jáchymová, EVA TVRZICKÁ, Marek Vecka et autres

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[Atherogenic dyslipidemia and the metabolic syndrome: pathophysiological mechanisms].

Aleš Žák, Adolf Slaby

Atherogenic dyslipidemia (ADL), a frequent metabolic derangement found in patients with manifest atherosclerosis, is characterized by hypertriglyceridemia, low plasma HDL cholesterol and prevalence of small dense LDL particles. The key pathogenetic mechanisms of ADL are closely linked to insulin resistance, the lack …

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