Tugba Kose

Quercetin Enhances Chemosensitivity in Gemcitabine-Treated MCF-7 Breast Cancer Cells

Tugba Kose, Şehriban Duyar Özer

Objective: Breast cancer remains a major contributor to cancer-related mortality among women globally, posing a major challenge to women’s health. Although chemotherapeutic agents such as gemcitabine (GEM) are widely used, their effectiveness is often limited by drug resistance and adverse side effects. …

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Dietary hempseed and cardiovascular health: nutritional composition, mechanisms and comparison with other seeds

Ömer Furkan Kaçar, Tugba Kose, Hüsna Kaya Kaçar

L.) has gained recognition as a functional food due to its rich nutritional profile, including high-quality plant proteins, optimal omega-6 to omega-3 fatty acid ratios, and a variety of bioactive compounds such as tocopherols, phytosterols, and polyphenols. This review critically evaluates the …

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The Impact of Heavy Metals on Pancreatic β-Cell Function: Mechanisms and Implications for Development of Diabetes Mellitus

Tugba Kose

Environmental exposure to heavy metals is an increasingly recognized risk factor in the development of metabolic disorders, including diabetes mellitus (DM). Pancreatic β-cells are particularly vulnerable to oxidative and functional damage induced by toxicants such as cadmium (Cd), arsenic (As), lead (Pb), …

The effect of fortification on in vitro iron and zinc bioavailability in plant-based meat alternatives

Tugba Kose, Tessa de Bie, Renzi Wang, Ans Eilander et autres

Plant-based diets are increasingly popular due to their perceived health benefits and positive environmental impact. However, there are concerns that long-term adherence to plant-based diets could result in nutritional deficiencies, especially for minerals found in abundance in animal foods. Therefore, plant-based meat …

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Effect of histidine and carnosine on haemoglobin recovery in anaemia induced-kidney damage and iron-loading mouse models

Mayra Vera‐Aviles, Jorge Moreno Fernández, Tugba Kose, Robert C. Hider et autres

, potentially providing stability to intracellular labile iron. Anaemia is a common comorbidity in the late stages of kidney disease, and patients are treated with erythropoiesis-stimulating agents (ESAs) and iron supplementation. However, iron supplementation is also associated with worse long-term outcomes. The …

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Antioxidative Effects of Curcumin on Erastin-Induced Ferroptosis Through GPX4 Signalling

Tugba Kose, Paul Sharp, Gladys Oluyemisi Latunde-Dada

Background/Objectives: Pancreatic cancer is a common gastrointestinal cancer with high risk of mortality. Currently, the therapeutic strategies for pancreatic cancers are surgery, chemotherapy, and radiotherapy, none of which are effective treatments. Ferroptosis is a new form of cell death that is iron …

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The food and nutritional insecurity experienced by pregnant women living in shelters following the 2023 earthquakes in Turkiye

Hüsna Kaya Kaçar, Ömer Furkan Kaçar, Tugba Kose, Amanda Avery

Natural hazards may limit household access to food and water. Shelters and food aid were provided as emergency measures following the 2023 earthquakes (EQ) in Turkiye. Pregnancy is a nutritionally vulnerable time. This study investigated weight changes, experienced level of food insecurity …

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Mechanistic Insights into Ferroptotic Cell Death in Pancreatic Islets

Florian Schepp, Undine Schubert, Janine Schmid, Susann Lehmann et autres

Ferroptosis was recently identified as a non-apoptotic, iron-dependent cell death mechanism that is involved in various pathologic conditions. There is first evidence for its significance also in the context of islet isolation and transplantation. Transplantation of pancreatic human islets is a viable …

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Ferulic acid protects HepG2 cells and mouse liver from iron-induced damage

Tugba Kose, Jorge Moreno Fernández, Mayra Vera‐Aviles, Paul Sharp et autres

Liver as iron storage organ is particularly susceptible to oxidative stress-induced injury from excess iron. Thus, antioxidant therapies are often used to reverse oxidative damage and protect cells and tissues. This study investigated the protective effects of phenolic acids; ferulic acid (FA) …

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Content and Availability of Minerals in Plant-Based Burgers Compared with a Meat Burger

Gladys Oluyemisi Latunde-Dada, Naroa Kajarabille, Sophie Rose, Sarah M. Arafsha et autres

Increasing numbers of individuals follow plant-based diets. This has sparked interest in the nutritional evaluation of the meat substitute sector. Nutritional understanding of these products is vital as plant-based eating becomes more common. For example, animal products are rich sources of iron …

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Phenolic Acids Rescue Iron-Induced Damage in Murine Pancreatic Cells and Tissues

Tugba Kose, Paul Sharp, Gladys Oluyemisi Latunde-Dada

Iron is an essential element involved in a variety of physiological functions. However, excess iron catalyzes the generation of reactive oxygen species (ROS) via the Fenton reaction. Oxidative stress, caused by an increase in intracellular ROS production, can be a contributory factor …

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The Food and Nutritional Insecurity Experienced by Pregnant Women Living in Shelters Following the 2023 Earthquakes in Turkiye

Hüsna Kaya Kaçar, Ömer Furkan Kaçar, Tugba Kose, Amanda Avery

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