Yannick Kaiser

Lipoprotein(a) and the Early Diagnosis, Complexity, and Extent of Coronary Artery Disease and Myocardial Infarction

Casper F. Coerkamp, Victor A. Verpalen, Kaoutar Bouhbouh, Mick Renkens et autres

BACKGROUND: Lipoprotein(a) [Lp(a)] is a potent, independent causal risk factor for coronary artery disease (CAD). OBJECTIVES: This study aimed to assess the association between Lp(a) and the diagnosis, clinical presentation, and angiographic characteristics of obstructive CAD and occurrence of myocardial infarction (MI). …

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Human monocyte inflammation in patients with Lp(a) or atherosclerotic cardiovascular disease is not accompanied by changes in chromatin accessibility in circulating classical monocytes

Rosalie W.M. Kempkes, Jordan M Kraaijenhof, Bram W. van Os, Yannick Kaiser et autres

BACKGROUND AND AIMS: High plasma lipoprotein(a) [Lp(a)] levels are associated with accelerated atherosclerosis and subsequent atherosclerotic cardiovascular disease (ASCVD), potentially through enhanced inflammatory signaling of monocytes. Given that monocytes are major players in ASCVD risk and the role of epigenetic changes in …

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First-in-human study of 99mTc-labeled fucoidan, a SPECT tracer targeting P-selectin

Reindert F. Oostveen, Kang H. Zheng, Yannick Kaiser, Nick S. Nurmohamed et autres

Abstract Background Activation of endothelial cells and platelets in atherothrombosis is characterized by upregulation of P-selectin. As a consequence, P-selectin represents a potential target for molecular imaging to identify thrombosis at an early stage. Fucoidan is a polysaccharide ligand extracted from brown …

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Ursodeoxycholic Acid for Trans Intestinal Cholesterol Excretion Stimulation: A Randomized Placebo Controlled Crossover Study

Reindert F. Oostveen, Yannick Kaiser, Merel L. Hartgers, Emma C. E. Meessen et autres

Background The trans intestinal cholesterol excretion (TICE) pathway is a potential therapeutic target to reduce plasma low‐density lipoprotein (LDL) cholesterol levels. TICE encompasses the direct excretion of cholesterol by enterocytes into feces. In mice, TICE has been shown to be stimulated by …

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Interleukin 6 plasma levels are associated with progression of coronary plaques

Jordan M Kraaijenhof, Nick S. Nurmohamed, Evangelos Tzolos, Mo Meah et autres

BACKGROUND: Inflammation plays a pivotal role in atherogenesis and is a causal risk factor for atherosclerotic cardiovascular disease. Non-invasive coronary CT angiography (CCTA) enables evaluation of coronary plaque phenotype. This study investigates the relationship between a comprehensive panel of inflammatory markers and …

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Lipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation

Nick S. Nurmohamed, Émilie Gaillard, Shant Malkasian, Robin J. de Groot et autres

Importance: Lipoprotein(a) (Lp[a]) is a causal risk factor for cardiovascular disease; however, long-term effects on coronary atherosclerotic plaque phenotype, high-risk plaque formation, and pericoronary adipose tissue inflammation remain unknown. Objective: To investigate the association of Lp(a) levels with long-term coronary artery plaque …

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Ursodeoxycholic acid for trans intestinal cholesterol excretion stimulation: a randomized placebo controlled cross-over study

Reindert F. Oostveen, Yannick Kaiser, Merel L. Hartgers, Emma C. E. Meessen et autres

Abstract Objective The Trans Intestinal Cholesterol Excretion (TICE) pathway is a potential therapeutic target to reduce plasma low-density lipoprotein (LDL) cholesterol levels. TICE encompasses the direct excretion of cholesterol by enterocytes into feces. In mice TICE has been shown to be stimulated …

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Abstract 18432: Lipoprotein(a) is Associated With Long-Term Plaque Progression, Pericoronary Inflammation and High-Risk Plaque on Serial Coronary CT Angiography

Nick S. Nurmohamed, Émilie Gaillard, Shant Malkasian, Michiel J. Bom et autres

Background This study investigated the effect of lipoprotein(a) (Lp[a]) on long-term plaque progression, high-risk plaque (HRP) and pericoronary adipose tissue attenuation (PCATa) in patients suspected of coronary artery disease. Methods: Per-protocol, patients from a coronary CT angiography (CCTA) cohort (Diemen et al., …

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Atorvastatin lowers 68Ga-DOTATATE uptake in coronary arteries, bone marrow and spleen in individuals with type 2 diabetes

Reindert F. Oostveen, Yannick Kaiser, Mia Ståhle, Nick S. Nurmohamed et autres

Abstract Aims/hypothesis Inflammation is a core component of residual cardiovascular risk in type 2 diabetes. With new anti-inflammatory therapeutics entering the field, accurate markers to evaluate their effectiveness in reducing cardiovascular disease are paramount. Gallium-68-labelled DOTATATE (68Ga-DOTATATE) has recently been proposed as …

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Can human trans intestinal cholesterol excretion be stimulated using ursodeoxycholic acid and ezetimibe: A randomized placebo controlled cross-over study

Reindert F. Oostveen, Laurens F. Reeskamp, Yannick Kaiser, Merel L. Hartgers et autres

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Lipoprotein(A) is associated with long-term plaque progression on serial coronary CT angiography

N. Nurmohamed, Emmanuel Gaillard, Michiel J. Bom, Ronald de Groot et autres

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INFLAMMATORY PLASMA MARKERS ARE ASSOCIATED WITH ACCELERATED CORONARY ARTERY PLAQUE PROGRESSION

Jordan M Kraaijenhof, Nick S. Nurmohamed, Evangelos Tzolos, Mohammed N. Meah et autres

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