Pedro de Atauri

La intel·ligència artificial pot substituir el professorat? Determinació de l’equació de la velocitat d’una reacció utilitzant la tècnica de King i Altman

Josep J. Centelles, Estefanía Moreno, Pedro de Atauri, Santıago Imperial

INTRODUCCIÓ. La tècnica de King i Altman és un mètode matemàtic per determinar la velocitat d’una reacció a partir del mecanisme de cinètica enzimàtica. Aquesta tècnica cerca el nombre de formes enzimàtiques (N) del mecanisme cíclic i les rutes amb N – …

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Problem-Based Learning for Calculating Kinetic Parameters from Michaelis-Menten Equation

Josep J. Centelles, Estefanía Moreno, Pedro de Atauri, Santıago Imperial

In “Advanced Enzymology” at the University of Barcelona, we teach various methods for identifying uni-uni irreversible reactions. Kinetic constants such as maximum velocity (Vmax) and Michaelis constant (Km) are calculated using non-linear regression with the Michaelis-Menten equation. However, if a computer is …

APRENDIZAJE BASADO EN JUEGOS: UNA ESCAPE-ROOM ON-LINE DE AMINOÁCIDOS Y PROTEÍNAS

Josep J. Centelles, Santıago Imperial, Sandra Pérez‐Torras, Estefanía Moreno et autres

APRESENTAÇÃOLa colección "Estudios Teórica-Metodológicas

Self-learning by Using Code-Based Games: An Easy Way to Learn Biomolecule’s Nomenclature

Josep J. Centelles, Estefanía Moreno, Pedro de Atauri

The Montessori method was an educational model devised at the beginning of the 20th century by the Italian pedagogue, physician, psychologist, and psychiatrist María Montessori (1870-1952). She observed that her students activated their intelligence and developed their personality by carrying out manual …

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Control analysis in the identification of key enzymes driving metabolic adaptations: Towards drug target discovery

Pedro de Atauri, Carles Foguet, Marta Cascante

Metabolic Control Analysis (MCA) marked a turning point in understanding the design principles of metabolic network control by establishing control coefficients as a means to quantify the degree of control that an enzyme exerts on flux or metabolite concentrations. MCA has demonstrated …

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Use of Several Grids in the Knight Tour’s Game to Find Shorter or Longer Biochemistry’s Sentences

Josep J. Centelles, Estefanía Moreno, Pedro de Atauri

Knight tour is a mathematical problem that was first solved by Leonhard Euler (1707-1785). The problem consists in finding if it is possible that the knight piece of chess can tour through all the boxes of a chess grid, passing only once …

Refuerzo de conocimientos de Bioquímica aplicando juegos de letras o de palabras sencillos

Josep J. Centelles, Estefanía Moreno, Pedro de Atauri

Introducción y problema: Los juegos son muy apreciados por la población en general, así que realizamos una búsqueda de diversos juegos con la finalidad de utilizarlos para reforzar los conocimientos en bioquímica de los alumnos del grado de Química de la Universidad …

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An Escape-Room about Krebs cycle prepared for Chemical Students

Silvia Marín, Pedro de Atauri, Estefanía Moreno, Sandra Pérez‐Torras et autres

Games are excellent teaching tools for self-learning. Students playing a game enjoy themselves and at the same time learn basic and important concepts. Different games including crossword puzzles, word search puzzles, knight’s tour games, connecting dots, mazes, matching two sets, amidakuji, and …

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Integrating systemic and molecular levels to infer key drivers sustaining metabolic adaptations

Pedro de Atauri, Míriam Tarrado‐Castellarnau, Josep Tarragó‐Celada, Carles Foguet et autres

Metabolic adaptations to complex perturbations, like the response to pharmacological treatments in multifactorial diseases such as cancer, can be described through measurements of part of the fluxes and concentrations at the systemic level and individual transporter and enzyme activities at the molecular …

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Mathematica Notebooks supporting "Integrating systemic and molecular levels to infer key drivers sustaining metabolic adaptations"

Pedro de Atauri, Míriam Tarrado‐Castellarnau, Josep Tarragó‐Celada, Carles Foguet et autres

Mathematica notebooks and data for journal article "Integrating systemic and molecular levels to infer key drivers sustaining metabolic adaptations". The zip file contains two Mathematica notebooks (“Wolfram Mathematica 11/12”; www.wolfram.com) and excel files with data for the generation of the final domains …

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Cysteine and Folate Metabolism Are Targetable Vulnerabilities of Metastatic Colorectal Cancer

Josep Tarragó‐Celada, Carles Foguet, Míriam Tarrado‐Castellarnau, Silvia Marín et autres

With most cancer-related deaths resulting from metastasis, the development of new therapeutic approaches against metastatic colorectal cancer (mCRC) is essential to increasing patient survival. The metabolic adaptations that support mCRC remain undefined and their elucidation is crucial to identify potential therapeutic targets. …

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Metabolomics: The Stethoscope for the Twenty-First Century

Hutan Ashrafian, Viknesh Sounderajah, Robert C. Glen, Timothy M. D. Ebbels et autres

Metabolomics encompasses the systematic identification and quantification of all metabolic products in the human body. This field could provide clinicians with novel sets of diagnostic biomarkers for disease states in addition to quantifying treatment response to medications at an individualized level. This …

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