Jordan R. Yaron

Dual-Dye Nanoparticle Inks for Multimodal Visualization in Surgical Applications

Mallikarjun Gosangi, Harsh Girish Sant, Sudhakar Godeshala, Vanshika Singh et autres

High Resolution Image Download MS PowerPoint Slide Multimodal imaging agents that improve the sensitivity and specificity of tissue visualization in surgery are critical for improving patient care outcomes. Single-modality dyes and nanoparticles have been adopted for tissue marking and visualization, including endoscopic …

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Tissue-Adhesive Endoscopic Tattoo Inks for Precise Marking and Surveillance of Gastrointestinal Lesions

Mallikarjun Gosangi, Jordan R. Yaron, Subhadeep Dutta, Harsh Girish Sant et autres

Abstract Accurate marking of lesions and polyps is essential for effective management of gastrointestinal (GI) diseases, including colorectal cancer. Existing FDA-approved endoscopic carbon suspensions diffuse extensively within tissue and can extravasate intraperitoneally, compromising lesion localization, increasing fibrosis risk, and triggering inflammatory responses. …

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Squamous cell carcinoma antigen-1/SerpinB3 is an endogenous skin injury response element

Jordan R. Yaron, Shubham Pallod, Sepideh Nezhadi, Holly M. Gildar et autres

The squamous cell carcinoma antigen SerpinB3 is a serum-circulating biomarker of epithelial cancers associated with high metastasis, treatment resistance, and poor prognosis. Despite its clinical significance, the endogenous role of SerpinB3 has remained undefined. Here, we identify SerpinB3 as a mediator of …

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Modulation of Secondary Structure, Bioavailability, Immunomodulation, and Tissue Repair Outcomes Using Differential Processing of Silk Biomaterials

Shubham Pallod, Weston DeCambra, Trishita Chowdhury, Eron Ristich et autres

The ability to modulate structure, physicochemical properties, and function makes naturally derived polypeptides attractive biomaterials for human health. Silk fibroin protein, derived from silkworm cocoons, has been explored in tissue engineering, wound healing, and drug delivery. Despite these advances, the influence of …

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Molecular Underpinnings of Zwitterionic Adhesion Barrier Biomaterials in Intestinal Surgery and Tissue Repair

Mallikarjun Gosangi, Vanshika Singh, Sudhakar Godeshala, Jordan R. Yaron et autres

Abdominal adhesions are a major cause of morbidity after gastrointestinal (GI) surgeries. Interventions, including those based on novel biomaterials, that reduce the incidence, severity, and adverse outcomes of postsurgical abdominal adhesions are still a critical unmet need. Here, we review the molecular …

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Histamine receptor agonism differentially induces immune and reparative healing responses in biomaterial-facilitated tissue repair

Jordan R. Yaron, Shubham Pallod, Nicole Grigaitis-Esman, Vanshika Singh et autres

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Skin repair and infection control in diabetic, obese mice using bioactive laser-activated sealants

Shubham Pallod, Rodrigo Aguilera Olvera, Deepanjan Ghosh, Lama Rai et autres

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Inflammasome modulation with P2X7 inhibitor A438079-loaded dressings for diabetic wound healing

Jordan R. Yaron, Selin Bakkaloglu, Nicole A. Grigaitis, Farhan H. Babur et autres

The inflammasome is a multiprotein complex critical for the innate immune response to injury. Inflammasome activation initiates healthy wound healing, but comorbidities with poor healing, including diabetes, exhibit pathologic, sustained activation with delayed resolution that prevents healing progression. In prior work, we …

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Bioactive nanomaterials kickstart early repair processes and potentiate temporally modulated healing of healthy and diabetic wounds

Deepanjan Ghosh, Jordan R. Yaron, Muhammad Raisul Abedin, Sudhakar Godeshala et autres

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In situ light‐activated materials for skin wound healing and repair: A narrative review

Jordan R. Yaron, Mallikarjun Gosangi, Shubham Pallod, Kaushal Rege

Dermal wounds are a major global health burden made worse by common comorbidities such as diabetes and infection. Appropriate wound closure relies on a highly coordinated series of cellular events, ultimately bridging tissue gaps and regenerating normal physiological structures. Wound dressings are …

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Rescue of dendritic cells from glycolysis inhibition improves cancer immunotherapy in mice

Sahil Inamdar, Abhirami P. Suresh, Joslyn L. Mangal, Nathan D. Ng et autres

Inhibition of glycolysis in immune cells and cancer cells diminishes their activity, and thus combining immunotherapies with glycolytic inhibitors is challenging. Herein, a strategy is presented where glycolysis is inhibited in cancer cells using PFK15 (inhibitor of PFKFB3, rate-limiting step in glycolysis), …

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Succinate in the tumor microenvironment affects tumor growth and modulates tumor associated macrophages

Sahil Inamdar, Abhirami P. Suresh, Joslyn L. Mangal, Nathan D. Ng et autres

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