Jean‐Pierre Gillet

Abcb5-deficient mice show a subtle, pleiotropic phenotype indicating a role for this transporter in intermediary metabolism

Jean‐Pierre Gillet, Louise Gerard, Wilfred D. Vieira, Marie Fourrez et autres

ABCB5 is a member of the ATP-binding cassette transporter superfamily that is expressed as a full transporter (ABCB5FL) and half transporter (ABCB5β). The ABCB5FL transporter mediates low-level multidrug resistance in cancer and is normally expressed in the prostate and testis, while ABCB5β …

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Identification of potential anticancer peptides from animal venoms using mass spectrometry techniques

Freuville Lou, M. Rivera Chloe, Violette Aude, Fourmy Rudy et autres

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The uniqueness of ABCB5 as a full transporter ABCB5FL and a half-transporter-like ABCB5β

Louise Gerard, Jean‐Pierre Gillet

gene encodes several isoforms, including two transporters (i.e., ABCB5FL, ABCB5β) and several soluble proteins, such as ABCB5α which has been hypothesized to have a regulatory function. ABCB5FL is a full ABC transporter and is expressed in the testis and prostate, whereas ABCB5β …

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Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5β/B6 and ABCB5β/B9

Louise Gerard, Laurent Duvivier, Marie Fourrez, Paula Salazar et autres

ABCB5 is a member of the ABC transporter superfamily composed of 48 transporters, which have been extensively studied for their role in cancer multidrug resistance and, more recently, in tumorigenesis. ABCB5 has been identified as a marker of skin progenitor cells, melanoma, …

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The β Isoform of Human ATP-Binding Cassette B5 Transporter, ABCB5β, Localizes to the Endoplasmic Reticulum

Adriana María Díaz-Anaya, Louise Gerard, Martine Albert, Jean‐François Gaussin et autres

ABCB5β is a member of the ABC transporter superfamily cloned from melanocytes. It has been reported as a marker of skin progenitor cells and melanoma stem cells. ABCB5β has also been shown to exert an oncogenic activity and promote cancer metastasis. However, …

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Linking ABC transporters to the hallmarks of cancer

Laurent Duvivier, Louise Gerard, Adriana Graciela Díaz, Jean‐Pierre Gillet

Human ATP-binding cassette (ABC) transporters are ubiquitously expressed and transport a broad range of endogenous and xenobiotic substrates across extra- and intracellular membranes. Mutations in ABC genes cause 21 monogenic diseases, and polymorphisms in these genes are associated with susceptibility to complex …

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Supplementary Figures 1 - 2, Table 1 from Multidrug Resistance–Linked Gene Signature Predicts Overall Survival of Patients with Primary Ovarian Serous Carcinoma

Jean‐Pierre Gillet, Anna Maria Calcagno, Sudhir Varma, Ben Davidson et autres

PDF file, 1202KB, Supplementary Figure 1. Kaplan-Meier Survival Curves. Supplementary Figure 2. Kaplan-Meier Survival Curves. Supplementary Table 1. Univariate analysis of clinical covariates.

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Supplementary Materials from Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database

Josiah N. Orina, Anna Maria Calcagno, Chung‐Pu Wu, Sudhir Varma et autres

Supplementary Materials from Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database

Supplementary Figures 1 - 2, Table 1 from Multidrug Resistance–Linked Gene Signature Predicts Overall Survival of Patients with Primary Ovarian Serous Carcinoma

Jean‐Pierre Gillet, Anna Maria Calcagno, Sudhir Varma, Ben Davidson et autres

PDF file, 1202KB, Supplementary Figure 1. Kaplan-Meier Survival Curves. Supplementary Figure 2. Kaplan-Meier Survival Curves. Supplementary Table 1. Univariate analysis of clinical covariates.

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Data from ABCA3 as a Possible Cause of Drug Resistance in Childhood Acute Myeloid Leukemia

Daniel Steinbach, Jean‐Pierre Gillet, Axel Sauerbrey, Bernd Gruhn et autres

Abstract Background: A major issue in the treatment of acute myeloid leukemia (AML) is resistance to chemotherapeutic drugs. Multidrug resistance can be caused by ATP-binding cassette (ABC) transporters that function as drug efflux pumps. The majority of these proteins have not yet …

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Data from Multidrug Resistance–Linked Gene Signature Predicts Overall Survival of Patients with Primary Ovarian Serous Carcinoma

Jean‐Pierre Gillet, Anna Maria Calcagno, Sudhir Varma, Ben Davidson et autres

Abstract Purpose: This study assesses the ability of multidrug resistance (MDR)–associated gene expression patterns to predict survival in patients with newly diagnosed carcinoma of the ovary. The scope of this research differs substantially from that of previous reports, as a very large …

Data from ABCA3 as a Possible Cause of Drug Resistance in Childhood Acute Myeloid Leukemia

Daniel Steinbach, Jean‐Pierre Gillet, Axel Sauerbrey, Bernd Gruhn et autres

Abstract Background: A major issue in the treatment of acute myeloid leukemia (AML) is resistance to chemotherapeutic drugs. Multidrug resistance can be caused by ATP-binding cassette (ABC) transporters that function as drug efflux pumps. The majority of these proteins have not yet …