Amanda Atanasio

Dysregulated tissue immunity in human fatal asthma

Yoon Seung Lee, Steven B. Wells, Daniel C. Yee, Daniel P. Caron et autres

Asthma is an immune-mediated lung disease causing airway constriction that is fatal in rare cases, though the immune mechanisms underlying asthma severity are poorly understood. Here, we present a comprehensive immunological profiling of lymphoid organs, lungs, and intestines from human organ donors …

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Utilizing an Indirect Basophil Activation Test to Interrogate the Potency of Bet v 1 and Related Allergens

Kaleigh Maloney, Amanda Atanasio, Lea Maney, Jamie Marie Orengo

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Immunological evaluation of cat allergic individuals living with or without a cat

Amanda Atanasio, Lea Maney, Abigail von Recklinghausen, Deepti Deshpande et autres

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IL4Ra blockade reduces Oral Immunotherapy outcome-related adverse events through inhibition of mast cell activity in a murine model of oral immunotherapy

Amanda Atanasio, Varsha Ganesan, Abigail von Recklinghausen, Lea Maney et autres

Prediction of symptomatic relief in allergic individuals using a preclinical mouse model of allergic anaphylaxis

Amanda Atanasio, Abigail von Recklinghausen, Michelle DeVeaux, André Limnander et autres

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Editorial: Allergen-specific antibodies: from basic science to clinical application

Sabine Flicker, Mats Ohlin, Amanda Atanasio, Anna Pomés

The present Special Research Topic "Allergen-specific Antibodies: From Basic Science to Clinical Application" offers a current snapshot about the latest findings concerning antibodybased approaches to study the development of allergic disorders, to establish efficient standardisation of allergen extracts and to employ antibodies …

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A novel mouse model for the study of Alpha-Gal Syndrome

Amanda Atanasio, Roberto Antonio Donnianni, Abigail von Recklinghausen, Lea Maney et autres

Dupilumab as an Adjunct to Oral Immunotherapy in Pediatric Patients With Peanut Allergy

R. Sharon Chinthrajah, Sayantani Sindher, Kari Christine Nadeau, Jeffrey G. Leflein et autres

BACKGROUND: Peanut allergy is a common, life-threatening food allergy in children. We evaluated whether dupilumab, which blocks the activity of interleukin (IL)-4/IL-13, enhances the efficacy of oral immunotherapy (OIT) AR101 in pediatric patients with peanut allergy. METHODS: A Phase II, multicenter, randomized, …

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IgE Sensitization Profiling Unveils Potential Risks of Fatal Asthma

Amanda Atanasio, Abigail von Recklinghausen, YoonSeung Lee, André Limnander et autres

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IL-4R alpha Blockade Reduces the Frequency and Severity of Food-induced Anaphylaxis in a Murine Model of Oral Immunotherapy

Amanda Atanasio, Varsha Ganesan, André Limnander, Matthew A. Sleeman et autres

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Differential modulation of allergic rhinitis nasal transcriptome by dupilumab and allergy immunotherapy

Matthew F. Wipperman, Kaitlyn M. Gayvert, Amanda Atanasio, Claire Q. F. Wang et autres

BACKGROUND: Nasal epithelial cells are important regulators of barrier function and immune signaling; however, in allergic rhinitis (AR) these functions can be disrupted by inflammatory mediators. We aimed to better discern AR disease mechanisms using transcriptome data from nasal brushing samples from …

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Production of large, defined genome modifications in rats by targeting rat embryonic stem cells

Jeffrey D. Lee, Jingjing Wang, Roxanne Ally, Sean Trzaska et autres

Rats were more frequently used than mice to model human disease before mouse embryonic stem cells (mESCs) revolutionized genetic engineering in mice. Rat ESCs (rESCs) were first reported over 10 years ago, yet they are not as frequently used as mESCs. CRISPR-based …

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