Liye Chen

Discovery of Potent and Orally Bioavailable Diaminoquinazoline-Derived mRNA Decapping Scavenger (DcpS) Enzyme Inhibitors for Treatment of Solid Tumors

Spencer O. Scholz, Alexander S. Dudnik, Aristidis Vasilopoulos, Zhaozhong J. Jia et autres

Decapping Scavenger (DcpS) enzyme, a pyrophosphatase involved in mRNA regulation via mRNA cap degradation, has been identified as a promising oncology target in fragile histidine triad (FHIT) deficient cancers such as AML and GBM but remains underexplored in broader solid tumor indications. …

us (code pays fourni par la source)

Dihydrobaicalein suppresses osteoclast differentiation and mitochondrial transfer to prevent postmenopausal osteoporosis

Wei Deng, Junxi Pan, Kai Tang, Tianzhao Tian et autres

cn (code pays fourni par la source)

Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study

Ghada Alsaleh, Mohammad Ali, Amir Hossein Kayvanjoo, Feng Liu et autres

Older adults are highly vulnerable to infectious diseases, and vaccines are often less effective in this population because of diminished B and T cell memory responses driven by impaired autophagy, immunosenescence, and chronic low-grade inflammation. Spermidine has been shown to counteract immunosenescence …

gb, de, at, kh (code pays fourni par la source)

RIVER delivers multimodal gene-directed regulatory interactions across diverse biological contexts with broad application potentials

Feng Li, Zhiqiang Zhang, Yizhu Diao, Shan Wang et autres

cn, fr, gb (code pays fourni par la source)

Research progress on the mechanism of Herba Epimedii in anti-osteoporosis

Liye Chen, Tienan HU, Hong Zhang, Daping QIN et autres

文章通过检索中国知网、万方、PubMed等数据库中近5年淫羊藿及其活性成分在防治骨质疏松症方面的实验与临床研究文献，系统总结了其作用机制与疗效。淫羊藿可通过调控Wnt/β-catenin、BMP/Runx2/Osx等信号通路促进成骨细胞增殖分化，抑制RANKL介导的破骨细胞活化及骨吸收；兼具调节脂代谢、炎症反应、雌激素样作用，并通过肠-骨轴与脑-骨轴多维度维持骨骼稳态。淫羊藿抗骨质疏松的多靶点机制逐渐明确，但其与其他疗法的协同效应及分子调控网络仍需深入研究。

Identification and Evaluation of Conserved Subunit Vaccine Candidates Conferring Cross‐Serotype Protection Against Streptococcus suis Serotypes 2, 7, 8, and 9

Shun Kang, Hongkun Zhuang, Zeren Peng, Liye Chen et autres

Streptococcus suis is a major zoonotic pathogen with substantial serotype diversity and remains a serious threat to global swine production and public health. Accordingly, vaccines capable of inducing cross‐serotype protection are urgently needed. Here, we integrated comparative genomics, bioinformatics, and reverse vaccinology …

cn, us (code pays fourni par la source)

Ultrasensitive Multiplexed Detection of Protein Biomarkers via Aptamer-Driven T7 RNA Polymerase Amplification

LI Yong-jun, Zixin Yang, Jiahao Wu, Liye Chen et autres

Accurate and multiplexed detection of protein biomarkers in complex biological fluids is essential for early diagnosis and precision medicine. However, existing technologies face critical trade-offs among sensitivity, specificity, multiplexing capability, and operational simplicity. Antibody-based assays like ELISA often lack the sensitivity for …

cn (code pays fourni par la source)

Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival

Jianling Xie, Kaikai Shen, Wenken Liang, Raj K. Shrestha et autres

Cancer cells exhibit accelerated protein production to accommodate their high rates of growth and proliferation. Elevated protein synthesis creates a dependency on endoplasmic reticulum (ER)-resident proteins and chaperones, which are required to maintain proteostasis. In this study, we identified the protein disulfide …

au, cn (code pays fourni par la source)

A computational medicine framework integrating multi-omics, systems biology, and artificial neural networks for Alzheimer's disease therapeutic discovery

Yisheng Yang, Lulu Jiang, Fanlu Li, Liye Chen et autres

The translation of genetic findings from genome-wide association studies into actionable therapeutics persists as a critical challenge in Alzheimer's disease (AD) research. Here, we present PI4AD, a computational medicine framework that integrates multi-omics data, systems biology, and artificial neural networks for therapeutic …

cn, gb (code pays fourni par la source)

Intelligent Detection and Control of Crop Pests and Diseases: Current Status and Future Prospects

Jiaxing Xie, Meiqin Lu, Liye Chen, Jinlin Wu et autres

Against the backdrop of a growing global population and intensifying climate change, crop pests and diseases have become significant challenges affecting agricultural production and food security. Efficient and precise detection and control of crop pests and diseases are crucial for ensuring yield …

cn (code pays fourni par la source)

CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue

Feng Liu, Hui Shi, Jason D. Turner, Rachel Anscombe et autres

OBJECTIVES: Interleukin (IL)-17A is a key driver of spondyloarthritis (SpA) joint pathology. We aimed to identify its cellular source in synovial tissue from patients with 2 forms of SpA, namely axial SpA (AxSpA) and psoriatic arthritis (PsA). METHODS: Synovial tissue from patients …

gb, se, de, cn, us (code pays fourni par la source)

Spermidine Mitigates Immune Cell Senescence, Enhances Autophagy, and Boosts Vaccine Responses in Healthy Older Adults.

Ghada Alsaleh, Mohammad Ali, Amir Hossein Kayvanjoo, Feng Liu et autres

gb, de, kh, cz, dk, at, ca (code pays fourni par la source)