Accès ouvert
2025
article
OpenAlex
Sophia K. Stegeman, Olena Kourko, Heather Amsden, Isabella E Pellizzari Delano et autres
BACKGROUND: The interactions between viruses and the host immune response are nuanced and intricate. The cytokine response arguably plays a central role in dictating the outcome of virus infection, balancing inflammation, and healing, which is crucial to resolving infection without destructive immunopathologies. …
ca
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2023
article
OpenAlex
John E. Mamatis, Carla E. Gallardo-Flores, Ujjwal Sangwan, Trinity H. Tooley et autres
The development of antivirals with an extended spectrum of activity is an attractive possibility to protect against future emerging coronaviruses (CoVs). Cyclosporine A (CsA), a clinically approved immunosuppressive drug, has established antiviral activity against diverse unrelated viruses, including several CoVs. However, its …
ca
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Accès ouvert
2023
preprint
OpenAlex
John E. Mamatis, Carla E. Gallardo-Flores, Taylor Walsh, Ujjwal Sangwan et autres
Abstract The development of antivirals with an extended spectrum of activity is an attractive possibility to protect against future emerging coronaviruses (CoVs). Cyclosporine A (CsA), a clinically approved immunosuppressive drug, has established antiviral activity against diverse unrelated viruses, including several CoVs. However, …
ca
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Accès ouvert
2022
article
OpenAlex
Stephen L. Archer, Asish Dasgupta, Kuang‐Hueih Chen, Danchen Wu et autres
Rationale Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 pneumonia. We hypothesize that SARS-CoV-2 causes alveolar injury and hypoxemia by damaging mitochondria in airway epithelial cells (AEC) and pulmonary artery smooth muscle cells (PASMC), triggering apoptosis and bioenergetic impairment, and impairing …
ca
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Accès ouvert
2022
article
OpenAlex
John E. Mamatis, Isabella E. Pellizzari-Delano, Carla E. Gallardo-Flores, Che C. Colpitts
Cellular cyclophilins (Cyps) such as cyclophilin A (CypA) have emerged as key players at the virus-host interface. As host factors required for the replication of many unrelated viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV) and coronaviruses (CoVs), Cyps are …
ca
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