Caiying Zhang

MAP-RAG: A Multi-View Adaptive Pattern-Aware Medical Retrieval-Augmented Generation Diagnostic Framework

Zhaolin Lu, X R Liu, Hongliang Bi, Feilong Tan et autres

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The crosstalk between fatty acid metabolism disorder and mitochondrial dysfunction is involved in hepatotoxicity co-induced by cadmium and molybdenum in ShaoXing duck (Anas platyrhyncha) livers

Shanxin Li, Gaohui Nie, Xueyan Dai, Jiamei Zhu et autres

Excessive molybdenum (Mo) and cadmium (Cd) exert negative influences on organism. Our prior experiments attested that Mo and Cd brought liver damage in ShaoXing ducks (Anas platyrhyncha); this injury mechanism has not yet been fully clarified. Hence, the hepatotoxicity mechanisms of Mo …

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TFEB Dysfunction Mediates Lysosomal Membrane Permeabilization-Induced Pyroptosis in Deoxynivalenol-Exposed Intestinal Epithelium

Chun Zeng, Zhenyu Zou, Xinyi Cheng, Yang Hu et autres

Deoxynivalenol (DON), a prevalent mycotoxin in cereals, triggers lysosomal membrane permeabilization (LMP) in intestinal epithelial cells, resulting in Transcription Factor EB (TFEB) dysfunction and subsequent pyroptosis. Both in vivo porcine jejunum and in vitro IPEC-J2 monolayer experiments revealed that DON exposure induced …

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Baicalin-copper complex alleviates intestinal damage in avian pathogenic Escherichia coli-infected chicks by targeting the AKT/NF-κB pathway

Panpan Cao, Jiazhen Wei, Xinyi Cheng, Yu Zhuang et autres

Background Avian pathogenic Escherichia coli (APEC), a primary bacterial pathogen in poultry, induces substantial economic losses to the global poultry industry. The baicalin-copper complex (BCU) demonstrates markedly potentiated anti-inflammatory, anti-oxidant, and anti-tumor efficacy relative to either baicalin or copper in their isolated …

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Curcumin alleviates atrazine-induced nephrotoxicity by enhancing mitophagy through PINK1/Parkin signaling pathway in mice

Zhenyu Zou, Xinyi Cheng, Jinyan Chen, Chenghong Xing et autres

Atrazine (ATR), a widely used herbicide, poses significant environmental and health risks due to its high solubility and adsorption in soil. ATR exposure can lead to nephrotoxicity in humans and animals. Curcumin (Cur), an active compound in Curcuma species, is renowned for …

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Luteolin attenuates LPS-induced damage in IPEC-J2 cells by enhancing mitophagy via AMPK signaling pathway activation

Ke Zhang, Lingling Yang, Xinyi Cheng, Jinyan Chen et autres

Background: Luteolin (LUT), a flavonoid compound widely present in natural plants, has been extensively studied for its diverse biological properties, involving anti-inflammatory,antioxidant, anti-apoptosis and other properties. Methods: The aim of this study was to investigate the effect of LUT on lipopolysaccharide (LPS)-induced …

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Pseudobensingtonia carpini sp. nov., a novel yeast species isolated from plant leaves in China

Chun-Yue Chai, Dan Lü, Caiying Zhang, Feng-Li Hui

Two novel yeast strains, NYNU 236247 and NYNU 23523, were isolated from the leaves of Carpinus turczaninowii Hance, collected in the Tianchi Mountain National Forest Park, Henan Province, central China. Phylogenetic analysis of the D1/D2 domain of the large subunit rRNA gene …

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Caspase-8 Regulates Endoplasmic Reticulum Stress-Mediated Apoptosis and Necroptosis Co-Induced by Molybdenum and Cadmium in Duck Hepatocytes

Li Xiao, Gaohui Nie, Xueyan Dai, Shenghui Li et autres

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AMPK-ULK1-Mediated Ferritinophagy Drives Ferroptosis in GLA-Induced Testicular Toxicity

Dianyun Wang, Caiying Zhang, Fan Yang, Yang Hu et autres

The health problem of infertility has garnered increasing attention, prompting a deeper understanding of its causes. The broad-spectrum and nonselective herbicide glufosinate ammonium (GLA) is widely used in many countries. Previous studies have demonstrated the reproductive toxicity of GLA, but its potential …

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Overexpression Bcl-2 alleviated ferroptosis induced by molybdenum and cadmium co-exposure through inhibiting mitochondrial ROS in duck kidneys

Hang Liu, Caiying Zhang, Shenghui Li, Sunan Wang et autres

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Aflatoxin B1 Promotes Pyroptosis in IPEC-J2 Cells by Disrupting Mitochondrial Dynamics through the AMPK/NLRP3 Pathway

Jiayi Ding, Xinyi Cheng, Chun Zeng, Qun Zhao et autres

Aflatoxin B1 (AFB1) is one of the most toxic mycotoxins in food and feed, seriously jeopardizing the intestinal health, while the effects of AFB1 on intestinal damage remain to be well understood. This study aims to evaluate the effect of AFB1 on …

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Activating PPARβ/δ-Mediated Fatty Acid β-Oxidation Mitigates Mitochondrial Dysfunction Co-induced by Environmentally Relevant Levels of Molybdenum and Cadmium in Duck Kidneys

Jiamei Zhu, Gaohui Nie, Xueyan Dai, Dianyun Wang et autres

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