Lauren Bolster

Using a Shared Infusion Clinic for Outpatient Management of Sickle Cell Vaso‐Occlusive Crisis as a Strategy of Decreasing Emergency Department Visits

Melissa Shyian, Lauren Bolster

Patients with sickle cell disease (SCD) experience high rates of emergency department (ED) visits and hospitalizations, primarily owing to vaso‐occlusive crises (VOC). In Edmonton, patients followed by the Centre for Bleeding and Rare Blood Disorders (CFBD) have access to the Medical Outpatient …

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Challenges in Trials in Sickle Cell Disease: Thromboprophylaxis in Sickle Cell Disease With Central Venous Catheters ( THIS ) Pilot Study

Jameel Abdulrehman, Stéphanie Forté, GEORGE A. TOMLINSON, Ziad Solh et autres

Individuals with sickle cell disease (SCD) often require central venous catheter (CVC) use; however, this is associated with a high incidence of venous thromboembolism (VTE). We conducted a pilot randomized controlled trial (RCT) to assess if it is feasible and safe to …

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Patient satisfaction with outpatient management of sickle cell pain crisis

Melissa Shyian, Lauren Bolster

Abstract Introduction: Vaso-occlusive crisis (VOC) causing pain is the most common reason for patients with sickle cell disease (SCD) to present to the emergency department (ED) for assessment. There have been many identified barriers to the provision of quality care in the …

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Adrenal insufficiency in sickle cell disease: A Case series of a potentially underrecognized complication

Renkun Zhuang, Lauren Bolster

Abstract Introduction: Endocrinopathies, including adrenal insufficiency (AI), are recognized complications that can occur in sickle cell disease (SCD). The exact prevalence of adrenal insufficiency (AI) in SCD is not known. However, there is a growing body of literature suggesting the prevalence of …

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A Real-World Evaluation of Frontline Treatment for Acute Myeloid Leukemia With Azacitidine Plus Venetoclax

Joseph M. Brandwein, David A. Page, Elena Liew, Mark Hnatiuk et autres

BACKGROUND: The combination of venetoclax + azacitidine (VenAza) has become the standard frontline treatment for older unfit AML patients. METHODS: We analyzed outcomes using VenAza for previously untreated unfit AML patients at a single center between 2020-2024. RESULTS: The overall response rate …

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An Atypical Presentation of Sarcoidosis

Chelsea Jocelyn Kubinec, Zaeem Azfer Siddiqi, Lauren Bolster, Christopher I. Fung et autres

Sarcoidosis is a multisystem disease characterized by non-caseating granulomatous organ infiltration. We describe an atypical presentation of sarcoidosis in a 43-year-old male presenting with fatigue and shortness of breath. He had a preceding history of recurrent venous thromboembolism (VTE), hemolytic anemia, cirrhosis, …

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THromboprophylaxis In Sickle Cell Disease with central venous catheters (THIS): an internal pilot randomised controlled trial protocol

Jameel Abdulrehman, Stéphanie Forté, GEORGE A. TOMLINSON, Ziad Solh et autres

INTRODUCTION: Individuals with sickle cell disease (SCD) and central venous catheters (CVC) are at high risk for venous thromboembolism (VTE). Minimal data exist regarding the use of anticoagulation as thromboprophylaxis of VTE in this demographic, and as a result, clinical equipoise exists. …

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Case Series of Paraspinal Extramedullary Hematopoiesis in Transfusion-Dependent Thalassemia Treated with Luspatercept

Ghaida Mreiwed, Haowei Sun, Lauren Bolster

Introduction: Extramedullary hematopoietic (EMH) pseudo-tumors are commonly seen in patients with non-transfusion dependent thalassemia but rare in transfusion-dependent beta thalassemia (TDT). Paraspinal EMH is more prevalent in older patients with severe ineffective erythropoiesis and low fetal hemoglobin levels. Luspatercept, an inhibitor of …

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Outpatient Management of Sickle Cell Vaso-Occlusive Crisis As a Strategy of Decreasing Emergency Department Visits

Melissa Shyian, Lauren Bolster

Background: Complications of sickle cell disease (SCD), including vaso-occlusive crises (VOC), usually require emergency room visits or even hospitalization for management. Outpatient treatment programs have been developed for management of VOC, however the literature is limited as to the efficacy of these …

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Changing frontline AML treatment patterns from 2013 to 2022

Joseph M. Brandwein, Kurt Ebeling, Lei Ding, Elena Liew et autres

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Complications of red cell exchange for anemia management in patients with transfusion‐dependent thalassemia

Erika Wall, Lauren Bolster

BACKGROUND: In the Rare Blood Disorders clinic at the University of Alberta in Edmonton, red cell exchange (RCE) was utilized in transfusion-dependent thalassemia (TDT) patients with severe iron overload despite oral chelation and no access to iron infusion pumps for parenteral chelation. …

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Geographic disparities in the care and outcomes in adult chronic immune thrombocytopenia

Erika Wall, John Podstawka, Jeffery M. Patterson, Lauren Bolster et autres

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