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2025
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OpenAlex
Min Xu, Saleh Alyemni, Veniamin A. Borin, Ranabir Majumder et autres
High Resolution Image Download MS PowerPoint Slide The sigma-2 receptor (σ 2 R/TMEM97) is a clinically relevant membrane protein involved in cholesterol regulation and overexpressed in cancer and neurodegenerative diseases. Despite its therapeutic potential, the dynamic mechanisms underlying σ 2 R function …
pk, gb, us, ru, no, in, sa
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2025
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OpenAlex
David W. Ussery, Pratul K. Agarwal
What can we learn from millions of viral genome sequences? David Ussery and Pratul Agarwal, Professors in the Department of Physiological Sciences at Oklahoma State University, discuss their work using high-performance computing for the analysis of millions of viral genome sequences. Advances …
us
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2025
article
OpenAlex
Shantanu Shukla, Laura Stingaciu, Christopher B. Stanley, Pratul K. Agarwal et autres
maltose-binding protein (tmMBP) isoforms show size-dependent differential binding of maltose and malto-oligomers while maintaining remarkable fold conservation. This differential behavior needs detailed characterization in native-like aqueous conditions to understand the effects of protein dynamics on ligand binding and recognition. Small-angle neutron scattering …
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2025
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OpenAlex
Kaitlin DeHart, Nicole M. Hoitsma, Spencer H. Thompson, Veniamin A. Borin et autres
contributes to an optimal electrostatic environment during the APE1 endonuclease reaction resulting in efficient AP site cleavage. Cumulatively, we demonstrate the importance of N174 in APE1's function and provide new insights into the molecular mechanism by which APE1 processes AP sites during …
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2025
preprint
OpenAlex
Tarosha Salpadoru, Sharmily Khanam, Veniamin A. Borin, Maha Achour et autres
The opportunistic human pathogen Pseudomonas aeruginosa (Pa), a leading cause of severe infections, becomes increasingly resistant to antibiotics, including the last resort antibiotic, polymyxin-B (PMB). Previous studies have shown that calcium (Ca 2+ ) at the levels encountered during infections increases Pa …
us
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2025
article
OpenAlex
Pratul K. Agarwal, Robert A. Bonomo, Shozeb Haider
High Resolution Image Download MS PowerPoint Slide Antimicrobial resistance (AMR) is a global threat, with Burkholderia species contributing significantly to difficult-to-treat infections. The Pen family of β-lactamases are produced by all Burkholderia spp., and their mutation or overproduction leads to the resistance …
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2025
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OpenAlex
Marinela Contreras, Marta Rafael, Isidro Sobrino, Consuelo Almazán et autres
Ticks and tick-borne diseases are a growing burden worldwide and vaccines are effective control interventions. Vaccine formulations with tick antigens such as BM86/BM95 (BM) and Subolesin (SUB) have shown reduction in tick fitness and infestation in immunized hosts. However, antigen combination is …
es, mx, cz, br, us, Ouganda
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2025
preprint
OpenAlex
Kaitlin DeHart, Nicole M. Hoitsma, Spencer H. Thompson, Veniamin A. Borin et autres
Abstract Apurinic/Apyrimidinic (AP)-sites are common and highly mutagenic DNA lesions that can arise spontaneously or as intermediates during Base Excision Repair (BER). The enzyme apurinic/apyrimidinic endonuclease 1 (APE1) initiates repair of AP-sites by cleaving the DNA backbone at the AP-site via its …
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2024
article
OpenAlex
Richard Van, Xiaoliang Pan, Saadi Rostami, Jin Liu et autres
The target DNA (tDNA) cleavage catalyzed by the CRISPR Cas9 enzyme is a critical step in the Cas9-based genome editing technologies. Previously, the tDNA cleavage from an active SpyCas9 enzyme conformation was modeled by Palermo and co-workers (Nierzwicki et al., Nat. Catal. …
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2024
preprint
OpenAlex
Jing Gu, Pratul K. Agarwal, Robert A Bonomo, Shozeb Haider
Antimicrobial resistance (AMR) is a global threat, with Burkholderia species contributing significantly to difficult-to-treat infections. Ambler Class A Pen β-lactamases are produced by all Burkholderia spp., and their mutation or overproduction leads to the resistance of β-lactam antibiotics. In this study we …
gb, us
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Accès ouvert
2024
preprint
OpenAlex
Richard Van, Xiaoliang Pan, Saadi Rostami, Jin Liu et autres
The target DNA (tDNA) cleavage catalyzed by the CRISPR Cas9 enzyme is a critical step in the Cas9-based genome editing technologies. Previously, the tDNA cleavage from an active SpyCas9 enzyme conformation was modeled by Palermo and coworkers [Nierzwicki et al., Nat. Catal. …
us
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Accès ouvert
2024
article
OpenAlex
Thi Thanh Quynh Tran, Chitra Narayanan, Andrea N. Loes, Timothy H. Click et autres
Evolutionarily conserved structural folds can give rise to diverse biological functions, yet predicting atomic-scale interactions that contribute to the emergence of novel activities within such folds remains challenging. Pancreatic-type ribonucleases illustrate this complexity, sharing a core structure that has evolved to accommodate …
ca, us
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