Masahiro Asari

Effect of sex differences on the emergence of ctDNA RAS mutations in RAS wild-type colorectal cancer

Kenta Iguchi, Mamoru Uchiyama, Masahiro Asari, Koji Numata et autres

In some cases of RAS wild-type metastatic colorectal cancer (mCRC), mutant RAS may emerge during chemotherapy. This study aimed to identify the clinicopathological factors associated with the emergence of RAS mutations during treatment. This single-center retrospective study included 43 patients with mCRC …

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Risk factors for male sexual dysfunction after minimally invasive surgery for rectal cancer: a multicenter prospective subanalysis of the LANDMARC study

Tsubasa Sakurai, Tomohiro Yamaguchi, Masakatsu Numata, Takashi Sakamoto et autres

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Prognostic Significance of the Modified Glasgow Prognostic Score in Patients Undergoing FOLFOXIRI plus Bevacizumab Therapy for Advanced or Metastatic Colorectal Cancer

Koji Numata, Yukari Ono, Kenta Iguchi, Mamoru Uchiyama et autres

INTRODUCTION: The prognostic value of the modified Glasgow Prognostic Score (mGPS), a systemic inflammatory response marker, has been reported in various cancers. However, its role in patients with metastatic colorectal cancer (mCRC) undergoing first-line FOLFOXIRI + bevacizumab (BV) therapy remains unclear. In …

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Observational study on the efficacy and safety of FOLFOXIRI therapy for locally advanced rectal cancer: The Kanagawa Yokohama Colorectal Cancer Study Group (KYCC)1802

Hironao Okamoto, Nobuhiro Sugano, Maho Sato, Kenta Iguchi et autres

PURPOSE: Although chemoradiotherapy is considered an efficacious treatment option for patients with locally advanced rectal cancer, the associated radiological toxicities and late anal dysfunction are concerning issues. Herein, we examined the efficacy and safety of folinic acid, 5-fluorouracil, oxaliplatin, and irinotecan (FOLFOXIRI) …

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Clinicopathological Features and Prognosis of Unresectable Colorectal Cancer With the BRAF V600E Mutation

Yukari Ono, Koji Numata, Kenta Iguchi, Mamoru Uchiyama et autres

Background/Aim: Patients with unresectable advanced and recurrent colorectal cancer (CRC) and the BRAF V600E mutation have poor prognosis, and conventional chemotherapy is often ineffective. This study aimed to retrospectively evaluate the clinicopathological features and prognosis of this patient population. Patients and methods: …

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Temporal dynamics of RAS mutations in circulating tumor DNA in metastatic colorectal cancer: clinical significance of mutation loss during treatment

Kenta Iguchi, Manabu Shiozawa, Mamoru Uchiyama, Masahiro Asari et autres

PURPOSE: In metastatic colorectal cancer (mCRC), RAS mutation loss may occur during the standard-of-care regimen. In this study, we aimed to investigate the temporal dynamics of the RAS gene and its clinical significance. METHODS: This was a retrospective, single-center study that included …

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Prospective observational study comparing the perioperative outcomes of laparoscopic colectomy with or without epidural anesthesia: the Kanagawa Yokohama Colorectal Cancer Study Group (KYCC) 1806

Aya Kato, Masakatsu Numata, Shota Izukawa, Takashi Ohgimi et autres

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Clinical Significance of the Post/Preoperative Anti-p53 Antibody Ratio in Predicting the Prognosis of Patients with Colorectal Cancer after Curative Surgery and Its Usefulness in Combination with Carcinoembryonic Antigen

Koji Numata, Manabu Shiozawa, Yukari Ono, Kenta Iguchi et autres

INTRODUCTION: Anti-p53 antibody (p53Ab) is useful for monitoring colorectal cancer (CRC) recurrence. We retrospectively analyzed the clinical impact of p53Ab ratio (p53R) before and after surgery to predict recurrence in patients with CRC. METHODS: In total, 1,223 patients with stage I-III CRC …

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A Case of Colon Cancer with Extramural Tumor Deposits in the Main Lymph Node Area: A Case Report

Yukari Ono, Arika Ida, Takashi Ogimi, Masahiro Asari et autres

A 72-year-old man with type 2 sub-circumferential tumors in the descending colon and two nodules around the pedicle of the inferior mesenteric artery (main lymph node area) underwent laparoscopic left hemicolectomy with D3 lymphadenectomy. Two lymph nodes around the inferior mesenteric artery …

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The first single-incision plus one-port transverse colon resection using Senhance Digital Laparoscopy System: a case report

Yume Minagawa, Yasumitsu Hirano, Atsuko Kataoka, Satoshi Shimamura et autres

BACKGROUND: We have introduced the Senhance Digital Laparoscopy System and actively use for colorectal cancer surgery. Recently, we also try to perform surgery by reduce port as less invasive method. For the first time, we report a case of single-incision plus one-port …

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Laparoscopic Surgery for Colorectal Cancer in Patients on Hemodialysis: A Propensity Score-matched Analysis

Nao Obara, Yasumitsu Hirano, Toshimasa Ishii, Hiroka Kondo et autres

BACKGROUND/AIM: Surgery on hemodialysis patients requires special attention, as the tissue of these patients is vulnerable and hemorrhagic. This study explored the feasibility of laparoscopic surgery for colorectal cancer in hemodialysis patients. PATIENTS AND METHODS: This was a retrospective study of patients …

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Preoperative C-reactive Protein as a Prognostic Factor in Stage IV Colorectal Cancer

Hiroka Kondo, Yasumitsu Hirano, Toshimasa Ishii, Shintaro Ishikawa et autres

Background A prognosis for stage IV colorectal cancer is generally poor. As a result, the development of an appropriate treatment strategy for each individual with this disease within a limited time frame is important. Few studies have been made of C-reactive protein …

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