Christian Löbke

Multilayer-Analyse der Signaltransduktion und Zellzykluskontrolle in GIST

Florian Haller, D. J. Zhang, Christian Löbke, Anja von Heydebreck et autres

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Reverse‐phase protein arrays for application‐orientated cancer research

Ulrike Korf, Christian Löbke, Ozgur D. Sahin, Florian Haller et autres

A detailed and quantitative analysis of disease-relevant signaling will greatly contribute to our understanding of tumorigenesis and cancer progression, and thus open new strategies for drug discovery. However, throughput and sensitivity of currently established methods available for proteome profiling do not comply …

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Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance

Ozgur D. Sahin, Holger Fröhlich, Christian Löbke, Ulrike Korf et autres

BACKGROUND: In breast cancer, overexpression of the transmembrane tyrosine kinase ERBB2 is an adverse prognostic marker, and occurs in almost 30% of the patients. For therapeutic intervention, ERBB2 is targeted by monoclonal antibody trastuzumab in adjuvant settings; however, de novo resistance to …

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Increased KIT signalling with up‐regulation of cyclin D correlates to accelerated proliferation and shorter disease‐free survival in gastrointestinal stromal tumours (GISTs) with KIT exon 11 deletions

Florian Haller, Christian Löbke, Markus Ruschhaupt, Stephan Schwager et autres

Gastrointestinal stromal tumours (GISTs) with deletions in KIT exon 11 are characterized by higher proliferation rates and shorter disease-free survival times, compared to GISTs with KIT exon 11 point mutations. Up-regulation of cyclin D is a crucial event for entry into the …

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Contact spotting of protein microarrays coupled with spike‐in of normalizer protein permits time‐resolved analysis of ERBB receptor signaling

Christian Löbke, Mark Laible, Claudia Rappl, Markus Ruschhaupt et autres

Protein microarrays allow highly accurate comparison and quantification of numerous biological samples in parallel while requiring only little material. This qualifies protein arrays for systems biology and clinical research where only limited sample material is available, but a precise readout is required. …

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Loss of 9p leads to p16INK4A down‐regulation and enables RB/E2F1‐dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs)

Florian Haller, Christian Löbke, Markus Ruschhaupt, Silke Cameron et autres

Loss of chromosome 9p is a reliable predictor of malignant behaviour in gastrointestinal stromal tumours (GISTs). p16INK4A located at 9p21 inhibits the CDK4/6/cyclin D complex from phosphorylating RB. Phosphorylation of RB through CDK4/6/cyclin D in early G(1) phase frees the transcription factor …

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Human Proteinpedia enables sharing of human protein data

Suresh Mathivanan, Mukhtar Ahmed, Natalie G. Ahn, Alexandre Hainard et autres

us, in, ch, at, se, dk, es, ie, ca, nl, it, be, de, cn, Afrique du Sud, jp, kr, gb, au (code pays fourni par la source)

Proteinarrays können Nebenwege von Tumor‐Wirkstoffen im Brustkrebs aufdecken

Ulrike Korf, Christian Löbke, Ozgur D. Sahin, Dorit Arlt et autres

Abstract Der so genannte HER2‐Rezeptor ist in vielen Tumoren, insbesondere der Brust, verstärkt zu finden. Dabei handelt es sich jedoch um nur einen Vertreter einer vier Mitglieder umfassenden Proteinfamilie, die bei Aktivierung unterschiedliche Signalwege vermitteln. Jetzt haben sich Forscher im Nationalen Genomforschungsnetz …

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Infrared-based protein detection arrays for quantitative proteomics

Ulrike Korf, Christian Löbke, Florian Haller, Holger Sültmann et autres

BACKGROUND: Protein microarrays have the potential to join the field of quantitative proteomics as a standard method. This antibody-based experimental platform allows the highly sensitive and highly specific quantification of selected target proteins and excels with high sample capacity. As a key …

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Antibody Microarrays as an Experimental Platform for the Analysis of Signal Transduction Networks

Ulrike Korf, Frauke Henjes, CHRISTIAN P. SCHMIDT, Achim Tresch et autres

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Combinatorial RNAi for quantitative protein network analysis

Ozgur D. Sahin, Christian Löbke, Ulrike Korf, Heribert Appelhans et autres

The elucidation of cross-talk events between intersecting signaling pathways is one main challenge in biological research. The complexity of protein networks, composed of different pathways, requires novel strategies and techniques to reveal relevant interrelations. Here, we established a combinatorial RNAi strategy for …

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Abi activates WASP to promote sensory organ development

Sven Bogdan, Raiko Stephan, Christian Löbke, Alexandra Mertens et autres

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