Marco Gualandi

IOS-1002, a Stabilized HLA-B57 Open Format, Exerts Potent Anti-Tumor Activity

Anahita Rafiei, Marco Gualandi, Chia-Lung Yang, Richard Woods et autres

HLA-B27 and HLA-B57 are associated with autoimmunity and long-term viral control and protection against HIV and HCV infection; however, their role in cancer immunity remains unknown. HLA class I molecules interact with innate checkpoint receptors of the LILRA, LILRB and KIR families …

865 iosH2 exerts potent anti-tumor activity by blocking LILRB1/2 and KIR3DL1 receptor signaling

Osiris Marroquin Belaunzaran, Anahita Rafiei, Anil Kumar, Marco Gualandi et autres

Background To develop novel anti-cancer therapeutics we have used a reverse rational approach and searched for human HLA class I molecules known to induce autoimmunity and long-term lasting viral control as a surrogate marker for potential anti-cancer activity. HLA-B*27 or HLA-B*57 are …

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Lineage-restricted sympathoadrenal progenitors confer neuroblastoma origin and its tumorigenicity

Chia-Lung Yang, André Serra‐Roma, Marco Gualandi, Nicole Bodmer et autres

// Chia-Lung Yang 1 , André Serra-Roma 1 , Marco Gualandi 1 , Nicole Bodmer 2 , Felix Niggli 2 , Johannes Hubertus Schulte 3 , Peter Karl Bode 4 and Olga Shakhova 1 1 Department of Medical Oncology and Hematology, University …

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Oncogenic ALKF1174L drives tumorigenesis in cutaneous squamous cell carcinoma

Marco Gualandi, Maria Iorio, Olivia Engeler, André Serra‐Roma et autres

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer characterized by increased mortality. Here, we show for the first time that anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase of the insulin receptor superfamily, plays a pivotal role in …

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Temporal activation of WNT/β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth

Rexhep Uka, Christian Britschgi, Anja Krättli, Claudia Matter et autres

Despite advances in the systemic treatment of patients with metastatic melanoma using immune checkpoint and tyrosine kinase inhibitors (TKI), the majority of stage IV melanoma patients eventually succumb to the disease. We have previously identified the transcription factor Sox10 as a crucial …

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Expression of the Neuroblastoma-Associated ALK-F1174L Activating Mutation During Embryogenesis Impairs the Differentiation of Neural Crest Progenitors in Sympathetic Ganglia

Lucie Vivancos Stalin, Marco Gualandi, Johannes H. Schulte, Raffaele Renella et autres

Neuroblastoma (NB) is an embryonal malignancy derived from the abnormal differentiation of the sympathetic nervous system. The Anaplastic Lymphoma Kinase (ALK) gene is frequently altered in NB, through copy number alterations and activating mutations, and represents a predisposition in NB-genesis when mutated. …

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The ALK F¹¹⁷⁴L-driven tale: from the cell -of-origin of neuroblastoma to novel oncogenic mechanisms in cutaneous squamous cell carcinoma

Marco Gualandi

The ALK F¹¹⁷⁴L-driven tale: from the cell -of-origin of neuroblastoma to novel oncogenic mechanisms in cutaneous squamous cell carcinoma

Marco Gualandi