Dongya Chen

Syndecan-4 in microglia mediates ischemic stroke-induced mitochondrial dysfunction and blood-brain barrier damage by interacting with Dishevelled

Dongya Chen, Dan Luo, Yuxing Wei

Ischemic stroke is a leading cause of disability and mortality, resulting in impaired mitochondrial function and disruption of the blood-brain barrier (BBB). Studies have demonstrated that Syndecan-4 (SDC4) influences BBB integrity and function, however, it remains unclear whether SDC4 influences mitochondrial function …

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Risk Assessment of Dibutyl Phthalate (DBP) and Bis(2-Ethylhexyl) Phthalate (DEHP) in Hot Pot Bases with a Hybrid Modeling Approach

Xiangyu Bian, Siyu Huang, Dongya Chen, Jing Jing et autres

(1) Background: Hot pot bases are susceptible to phthalate (PAE) contamination due to their high lipid content. Standard risk models often fail to capture extreme values, leading to biased exposure estimates. This study characterized dibutyl phthalate (DBP) and bis(2-ethylhexyl) phthalate (DEHP) contamination …

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Associations between Metabolic Syndrome Indicators and Colon Polyps: A Mendelian Randomization Study

Dongya Chen, Hong Wei Xu, Zhaolin Zhang, Fang Chen et autres

BACKGRUOUND: While observational studies have suggested a potential link between metabolic syndrome (MetS) and an increased risk of colon polyps, the causal nature of this association remains uncertain. This study used a two-sample Mendelian randomization (MR) approach to evaluate the relationship between …

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Syndecan-4 in microglia mediates ischemic stroke-induced mitochondrial dysfunction and blood-brain barrier damage by interacting with Dishevelled

Dongya Chen, Dan Luo, Yuxing Wei

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Portal hypertension caused by essential thrombocythemia: A case report

Fang Yutao, Kaili Xiang, Yihui Liu, L.X. Tao et autres

RATIONALE: Portal hypertension (PHT) results from increased intrahepatic vascular resistance and augmented portal venous blood flow. Although cirrhosis remains the predominant etiology of PHT, non-cirrhotic PHT also requires clinical attention. This article reports a rare case of PHT with portal vein thrombosis …

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Berberine Repairs Intestinal Mucosal Barrier by Targeting HSP90AA1 and MAPK14

Danya Zhao, Yuelin Zhai, Chen Chen, Junkang Chen et autres

Background: Berberine (BBR), a key compound in Coptis chinensis, has broad pharmacological properties, though its specific Crohn's disease (CD) targets and mechanisms are undefined. Materials and Methods: We employed network pharmacology, mendelian randomization (MR), molecular docking, and molecular dynamics simulations to identify …

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Microbial-Modified Organosilica-Based Dual-Mode Fluorescent Probe for Zn²⁺ and pH Sensing with Potential Application in Gut Immunity Modulation

Qingqing Han, Fang Chen, Z. Zhang, Dongya Chen

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Code for: Semi-Supervised Colonoscopy Depth Estimation via Lighting Adjustment Model-Driven Soft Labels

Xiheng Wu, Z.-C. Zhang, ZM Xu, Entong Liu et autres

Accurate polyp size measurement during colonoscopy is essential for colorectal cancer diagnosis; however, monocular depth estimation is significantly affected by complex lighting variations, including mucus reflections, exposure inconsistencies, and synthetic-to-real domain gaps. To address these challenges, we propose LAM-Soft, a semi-supervised framework …

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Code for: Semi-Supervised Colonoscopy Depth Estimation via Lighting Adjustment Model-Driven Soft Labels

Xiheng Wu, Z.-C. Zhang, ZM Xu, Entong Liu et autres

Accurate polyp size measurement during colonoscopy is essential for colorectal cancer diagnosis; however, monocular depth estimation is significantly affected by complex lighting variations, including mucus reflections, exposure inconsistencies, and synthetic-to-real domain gaps. To address these challenges, we propose LAM-Soft, a semi-supervised framework …

cn (code pays fourni par la source)

Efficacy and safety of Shouhui Tongbian Capsules, a traditional Chinese medicine, combined with 2L polyethylene glycol for bowel preparation before colonoscopy: a multicenter, randomized, single-blind, parallel-controlled clinical trial

Feng Ye, Ni Guo, Yaping Wang, Baochun Wang et autres

Background: High-volume polyethylene glycol (PEG) solutions are commonly used for bowel preparation but are often poorly tolerated, reducing patient compliance. Shouhui Tongbian Capsules (SHTBC), a traditional Chinese medicine known to promote gastrointestinal motility, may offer an alternative approach. However, its role in …

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Gan-tang-yi decoction improves hepatic insulin resistance through activation of IRS2/PI3K/Akt pathway and inhibition of AGEs/RAGE pathway in cirrhotic rats

Na Jiang, Gao‐Feng Chen, Ying He, Jingfang Xiong et autres

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Lam-Cycle: Cycle-Consistent Semi-Supervised Monocular Depth Estimation in Colonoscopy Using Lighting Adjustment Model

Xingfang Wu, Zhaolin Zhang, Zhe Xu, Entong Liu et autres

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