Accès ouvert
2026
article
OpenAlex
Ryo Terao, Ryosuke Fujino, Kentarō Hayashi, Takafumi Suzuki et autres
Retinal vein occlusion (RVO) is a common vascular disease that leads to vision loss due to macular edema (ME). This study investigated the role of autotaxin (ATX), a lysophospholipase D, in the pathogenesis of RVO. In mice, RVO was induced by intravenous …
jp
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Accès ouvert
2025
article
OpenAlex
Takafumi Suzuki, Ryo Terao, Masako Nagahara, Kentarō Hayashi et autres
Purpose: Ferroptosis, characterized by lipid peroxidation, has been implicated in retinal pigment epithelium (RPE) degeneration in dry age-related macular degeneration (AMD). This study aimed to investigate the role of calcium-independent phospholipase A2 group VI (iPLA2β) in protecting RPE cells from oxidative stress …
jp
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Accès ouvert
2025
article
OpenAlex
Ryosuke Fujino, Kiyoto Totsuka, Tomoyasu Shiraya, Takashi Ueta et autres
OBJECTIVE: Macular laser for diabetic macular edema (DME) is known to increase heat shock protein (HSP) expression in retinal pigment epithelial (RPE) cells, and increased HSP expression may be a mechanism for improving macular edema. Furthermore, the effectiveness of mild electrical stimulation …
jp
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Accès ouvert
2025
article
OpenAlex
Takafumi Suzuki, Masako Nagahara, Kentarō Hayashi, Tomoyasu Shiraya et autres
Pathologic myopia, a vision-threatening subtype of myopia, is characterized by axial elongation accompanied by chorioretinal atrophy and scleral remodeling. While lens-induced and form-deprivation myopia models have elucidated the role of visual input in ocular growth, the contribution of retinal pigment epithelium (RPE) …
jp
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Accès ouvert
2025
article
OpenAlex
Murilo M. Marinho, Yuki Koyama, Yuta Taniguchi, Toshiro Yamanaka et autres
ABSTRACT Background Robot‐assisted vitreoretinal surgery makes it easier for the surgeons to perform precise and dexterous manipulations required in vitreoretinal procedures. Methods We systematically evaluated manual surgery, conventional two‐hand teleoperation, a novel one‐hand teleoperation, and automation in a needle positioning task using …
jp, gb
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Accès ouvert
2025
conference-abstract
OpenAlex
Yuki HATA, Syotaro MIZUGUCHI, Seiji Omata, Kanako Harada et autres
Glaucoma is an intraocular disease characterized by specific changes in the optic nerve and visual field, where adequately lowering intraocular pressure typically contributes to suppressing or improving optic nerve damage. Current medical education relies heavily on verbal instruction, and the development of …
jp
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Accès ouvert
2024
article
OpenAlex
Kunihiro Azuma, Takafumi Suzuki, Kenta Kobayashi, Masako Nagahara et autres
Abstract Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population, particularly the late-stage of dry AMD known as geographic atrophy (GA), lacks effective treatment options. Genetic mouse models of AMD have revealed the significance of …
jp
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Accès ouvert
2024
article
OpenAlex
Kunihiro Azuma, Toshiro Iwagawa, Sumiko Watanabe, Makoto Aihara et autres
Epithelial-Mesenchymal Transition (EMT) of retinal pigment epithelial (RPE) cells is recognized as pivotal in various retinal diseases. Previous studies have suggested a reciprocal regulation between reactive oxygen species (ROS) and EMT, though the involvement of peroxidized lipids or the effects of reducing …
jp
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Accès ouvert
2024
preprint
OpenAlex
Takashi Ueta, Kunihiro Azuma, Kenta Kobayashi, Takafumi Suzuki et autres
Abstract Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the elderly population, particularly the late-stage of dry AMD known as geographic atrophy (GA), lacks effective treatment options. Genetic mouse models of AMD have revealed the significance of …
jp
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Accès ouvert
2024
review
OpenAlex
Hironori Hosoya, Takashi Ueta, Kazunori Hirasawa, Taku Toyama et autres
PURPOSE: To evaluate the effects of subthreshold micropulse laser (SML) in addition to anti-vascular endothelial growth factor (VEGF) therapy for diabetic macular edema (DME). METHODS: MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials were systematically searched for studies that compared anti-VEGF …
jp
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2024
article
OpenAlex
Takashi Ueta, Tomoyuki Matsuura, Kiyohiyo Totsuka, Koichiro Sugimoto et autres
PURPOSE: None of the authors has any financial/conflicting interests to disclose.The aim of this study was to report a surgical technique of cyclopexy, wherein two laps of encircling continuous sutures are placed around the limbus to treat refractory extensive cyclodialysis. METHODS: This …
jp
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Accès ouvert
2023
article
OpenAlex
Yuka Numaga, Fumiyuki Araki, Kunihiro Azuma, Taku Toyama et autres
Purpose: To report a case of bilateral vitreous hemorrhage (VH) resulting in postoperative vision loss (POVL) after robot-assisted laparoscopic hysterectomy in a 71-year-old female patient. Observations: At initial presentation, best-corrected visual acuity was hand motion at 20 cm in the right eye …
jp
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